公开(公告)号：US11130758B2

公开(公告)日：2021-09-28

申请号：US16845594

申请日：2020-04-10

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Roch Boivin ,  Eric Carlson ,  Atsushi Endo ,  Hans Hansen ,  Lynn D. Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Sridhar Narayan ,  Takashi Satoh ,  Shawn Schiller

IPC: C07D487/04 ,  C07D471/04 ,  A61K31/519 ,  A61K31/55

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

公开(公告)号：US10745387B2

公开(公告)日：2020-08-18

申请号：US15529798

申请日：2016-11-17

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Gregg F. Keaney ,  John Wang ,  Baudouin Gerard ,  Kenzo Arai ,  Xiang Liu ,  Guo Zhu Zheng ,  Kazunobu Kira ,  Parcharee Tivitmahaisoon ,  Sudeep Prajapati ,  Nicholas C. Gearhart ,  Yoshihiko Kotake ,  Satoshi Nagao ,  Regina Mikie Kanada Sonobe ,  Masayuki Miyano ,  Norio Murai ,  Silvia Buonamici ,  Lihua Yu ,  Eunice Sun Park ,  Betty Chan ,  Peter G. Smith ,  Michael P. Thomas ,  Ermira Pazolli ,  Kian Huat Lim ,  Atsushi Endo ,  Arani Chanda

IPC: A61K31/496 ,  C07D295/182 ,  C07D405/14 ,  C07D405/06 ,  A61P35/02

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

公开(公告)号：USRE47193E1

公开(公告)日：2019-01-08

申请号：US15668887

申请日：2017-08-04

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： J. Eric Carlson ,  Hans Hansen ,  Lynn Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Shawn Schiller ,  Chikako Ogawa ,  Heather Davis ,  Atsushi Endo

IPC: C07D413/04 ,  C07D401/14 ,  C07D403/14 ,  C07D401/10 ,  C07D413/14 ,  C07D417/14 ,  C07D215/48 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C12Q1/6897 ,  C07D493/10 ,  C07D487/04 ,  G01N33/50 ,  C07D451/04

Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

公开(公告)号：US09802953B2

公开(公告)日：2017-10-31

申请号：US15092850

申请日：2016-04-07

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Charles E. Chase ,  Atsushi Endo ,  Francis G. Fang ,  Jing Li

IPC: C07D493/22 ,  C07D307/28 ,  C07D307/33 ,  C07D493/08 ,  C07D493/18 ,  C07D493/20 ,  C07D493/04

CPC classification number: C07D493/20 ,  C07D307/20 ,  C07D307/26 ,  C07D307/28 ,  C07D307/33 ,  C07D309/16 ,  C07D405/06 ,  C07D405/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/18 ,  C07D493/22 ,  Y02P20/55

Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.

公开(公告)号：US09663486B2

公开(公告)日：2017-05-30

申请号：US14908164

申请日：2014-10-14

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Roch Boivin ,  Hans Hansen ,  Sally Ishizaka ,  Matthew Mackey ,  Shawn Schiller ,  Chikako Ogawa ,  Sridhar Narayan ,  Peter Bertinato ,  Gregory Berger ,  Atsushi Endo ,  Robert T. Yu ,  Lynn Hawkins

IPC: C07D401/02 ,  C07D413/14 ,  C07D471/04 ,  C07D401/14 ,  C07D417/14 ,  C07D401/04

CPC classification number: C07D401/02 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

公开(公告)号：US09428495B2

公开(公告)日：2016-08-30

申请号：US14513556

申请日：2014-10-14

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Eric Carlson ,  Hans Hansen ,  Lynn Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Shawn Schiller ,  Chikako Ogawa ,  Heather Davis ,  Atsushi Endo

IPC: C07D413/04 ,  C07D413/14 ,  C07D401/10 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C07D215/48

CPC classification number: C07D417/14 ,  C07B2200/07 ,  C07D215/48 ,  C07D401/10 ,  C07D401/14 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14 ,  C07D451/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D493/10 ,  C12Q1/6897 ,  G01N33/5023 ,  G01N33/5047

Abstract: Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract translation: 本公开的实施方案涉及用作Toll样受体7和/或8的拮抗剂或抑制剂的选择性取代的喹啉化合物及其在有效治疗系统性红斑狼疮（SLE）和狼疮性肾炎的药物组合物中的用途。

公开(公告)号：US20160030430A1

公开(公告)日：2016-02-04

申请号：US14806174

申请日：2015-07-22

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Roch Boivin ,  Eric Carlson ,  Atsushi Endo ,  Hans Hansen ,  Lynn D. Hawkins ,  Sally Ishizaka ,  Matthew Mackey ,  Sridhar Narayan ,  Takashi Satoh ,  Shawn Schiller

IPC: A61K31/519

CPC classification number: C07D471/04 ,  A61K31/519 ,  A61K31/55 ,  C07D487/04 ,  Y02P20/582

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis