公开(公告)号：US20240026409A1

公开(公告)日：2024-01-25

申请号：US18450950

申请日：2023-08-16

Applicant: EVOLVA SA

Inventor： Kim Olsson ,  Ernesto Simon ,  Michael Dalgaard Mikkelsen ,  Simon Carlsen ,  Veronique Douchin ,  Swee Chuang Lim ,  Louis During

IPC: C12P19/56 ,  C12N9/10 ,  C12P15/00 ,  C07H15/256

CPC classification number: C12P19/56 ,  C12N9/1051 ,  C12Y204/01 ,  C12P15/00 ,  C07H15/256

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.

公开(公告)号：US11807888B2

公开(公告)日：2023-11-07

申请号：US17243904

申请日：2021-04-29

Applicant: EVOLVA SA

Inventor： Kim Olsson ,  Ernesto Simon ,  Michael Dalgaard Mikkelsen ,  Simon Carlsen ,  Veronique Douchin ,  Swee Chuang Lim ,  Louis During

IPC: C12P19/56 ,  C12N9/10 ,  C12P15/00 ,  C07H15/256

CPC classification number: C12P19/56 ,  C07H15/256 ,  C12N9/1051 ,  C12P15/00 ,  C12Y204/01

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.

公开(公告)号：US20230212630A1

公开(公告)日：2023-07-06

申请号：US17899069

申请日：2022-08-30

Applicant: EVOLVA SA

Inventor： Helene Lunde Robertson ,  Iben Nordmark Andersen ,  Adam Matthew Takos ,  Swee Chuang Lim Hallwyl ,  Francesca Ambri ,  Manuel Quiros Asensio ,  Michael Dalgaard Mikkelsen ,  Jens Houghton-Larsen ,  Veronique Douchin ,  Jane Dannow Dyekjaer ,  Simon Carlsen ,  Nina Nicoline Rasmussen ,  Esben Halkjaer Hansen

IPC: C12P19/56 ,  A23L27/30 ,  C12N9/02 ,  C12N15/52 ,  C07H15/256 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90

CPC classification number: C12P19/56 ,  A23L27/36 ,  C12Y114/13078 ,  C12N9/0042 ,  C12N9/0073 ,  C12N15/52 ,  C07H15/256 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12Y106/02004 ,  C12Y114/13079 ,  C12Y205/01029 ,  C12Y402/03019 ,  C12Y505/01013 ,  C07K2319/00 ,  A23V2002/00

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US20230033436A1

公开(公告)日：2023-02-02

申请号：US17243904

申请日：2021-04-29

Applicant: EVOLVA SA

Inventor： Kim Olsson ,  Ernesto Simon ,  Michael Dalgaard Mikkelsen ,  Simon Carlsen ,  Veronique Douchin ,  Swee Chuang Lim ,  Louis During

IPC: C12P19/56 ,  C12N9/10 ,  C12P15/00 ,  C07H15/256

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.

公开(公告)号：US20220127655A1

公开(公告)日：2022-04-28

申请号：US17464144

申请日：2021-09-01

Applicant: EVOLVA SA

Inventor： Veronique Douchin ,  Michael Dalgaard Mikkelsen ,  Iben Møller-Hansen

IPC: C12P19/44 ,  A23L27/30 ,  C07H1/08 ,  C12N1/16

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US20200017896A1

公开(公告)日：2020-01-16

申请号：US16434202

申请日：2019-06-07

Applicant: EVOLVA SA

Inventor： Kim Olsson ,  Ernesto Simon ,  Michael Dalgaard Mikkelsen ,  Simon Carlsen ,  Veronique Douchin ,  Swee Chuang Lim ,  Louis During

IPC: C12P19/56 ,  C12N9/10 ,  C12P15/00 ,  C07H15/256

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.

公开(公告)号：US10364450B2

公开(公告)日：2019-07-30

申请号：US15541686

申请日：2016-01-29

Applicant: EVOLVA SA

Inventor： Kim Olsson ,  Ernesto Simon ,  Michael Dalgaard Mikkelsen ,  Simon Carlsen ,  Veronique Douchin ,  Swee Chuang Lim ,  Louis During

IPC: C12N9/04 ,  C12P19/56 ,  C12N9/10 ,  C12P15/00 ,  C07H15/256

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.

公开(公告)号：US20170240942A1

公开(公告)日：2017-08-24

申请号：US15506196

申请日：2015-09-09

Applicant: EVOLVA SA

Inventor： Helene Lunde Robertson ,  Iben Nordmark Andersen ,  Adam Matthew Takos ,  Swee Chuang Lim Hallwyl ,  Francesca Ambri ,  Manuel Quiros Asensio ,  Michael Dalgaard Mikkelsen ,  Jens Houghton-Larsen ,  Veronique Douchin ,  Jane Dannow Dyekjaer ,  Simon Carlsen ,  Nina Nicole Rasmussen ,  Esben Halkjaer Hansen

IPC: C12P19/56 ,  C12N9/02 ,  A23L27/30 ,  C12N9/90 ,  C12N9/88 ,  C12N15/52 ,  C07H15/256 ,  C12N9/10

CPC classification number: C12P19/56 ,  A23L27/36 ,  A23V2002/00 ,  C07H15/256 ,  C07K2319/00 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y114/13079 ,  C12Y205/01029 ,  C12Y402/03019 ,  C12Y505/01013

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.

公开(公告)号：US20150361476A1

公开(公告)日：2015-12-17

申请号：US14764898

申请日：2014-02-11

Applicant: EVOLVA SA

Inventor： Ernesto Simon ,  Iben Nordmark Anderson ,  Michael Dalgaard Mikkelsen ,  Jorgen Hansen ,  Veronique Douchin

IPC: C12P19/56 ,  C07K14/395 ,  C12N9/88 ,  C12N9/10 ,  C12N9/02

CPC classification number: C12P19/56 ,  C07K14/395 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1062 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12P15/00 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y204/00 ,  C12Y204/01013 ,  C12Y204/01035 ,  C12Y205/01029 ,  C12Y402/03 ,  C12Y402/03019 ,  C12Y505/01013

Abstract: Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes, or that overexpress one or more heterologous transporters, leading to increased excretion of steviol glycosides of interest.

Abstract translation: 公开了重组微生物，其产生甜菊糖苷并且改变一种或多种内源性转运蛋白或转录因子基因的表达，或者过表达一种或多种异源转运蛋白，导致感兴趣的甜菊糖苷的排泄增加。