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公开(公告)号：US20220017932A1
公开(公告)日：2022-01-20
申请号：US17244089
申请日：2021-04-29
申请人： EVOLVA SA
发明人： Ernesto Simon , Iben Nordmark Anderson , Michael Dalgaard Mikkelsen , Jorgen Hansen , Veronique Douchin
摘要： Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes, or that overexpress one or more heterologous transporters, leading to increased excretion of steviol glycosides of interest.
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公开(公告)号：US10435730B2
公开(公告)日：2019-10-08
申请号：US15439660
申请日：2017-02-22
申请人： Evolva SA
发明人： Jens Houghton-Larsen , Paula Hicks , Michael Naesby , Thomas Tange Ostergaard , Jorgen Hansen , Michael Mikkelsen Dalgaard , Esben Hansen Halkjaer , Ernesto Simon , Sabina De Andrade Periera Tavares
IPC分类号： C12P19/56 , C12N9/10 , C12N9/02 , C12N1/21 , C12N9/88 , C12N9/06 , C12N9/90 , C12N15/81 , C12N15/82 , C12P19/44 , C12N15/63
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
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公开(公告)号：US20190203243A1
公开(公告)日：2019-07-04
申请号：US15908214
申请日：2018-02-28
申请人： EVOLVA SA
发明人： Michael Dalgaard Mikkelsen , Jorgen Hansen , Ernesto Simon , Federico Brianza , Angelika Semmler , Kim Olsson , Simon Carlsen , Louis Düring , Alexei Ouspenski , Paula Hicks
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , A23V2002/00 , C12N9/0071 , C12N9/1051 , C12N9/1081 , C12N9/1085 , C12N9/90 , C12N15/81 , C12Y204/01 , C12Y204/99
摘要： Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
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公开(公告)号：US20180371517A1
公开(公告)日：2018-12-27
申请号：US16002245
申请日：2018-06-07
申请人： EVOLVA SA
发明人： Ernesto Simon , Iben Nordmark Anderson , Michael Dalgaard Mikkelsen , Jorgen Hansen , Veronique Douchin
摘要： Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes or that overexpress one or more heterologous transporters, leading to increased excretions of steviol glucosides of interest.
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公开(公告)号：US09957540B2
公开(公告)日：2018-05-01
申请号：US14761629
申请日：2014-02-06
申请人： Evolva SA
发明人： Michael Dalgaard Mikkelsen , Jorgen Hansen , Ernesto Simon , Federico Brianza , Angelika Semmler , Kim Olsson , Simon Carlsen , Louis Düring , Alexei Ouspenski , Paula Hicks
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , A23V2002/00 , C12N9/0071 , C12N9/1051 , C12N9/1081 , C12N9/1085 , C12N9/90 , C12N15/81 , C12Y204/01 , C12Y204/99
摘要： Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided herein.
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公开(公告)号：US20170369922A1
公开(公告)日：2017-12-28
申请号：US15541686
申请日：2016-01-29
申请人： EVOLVA SA
发明人： Kim Olsson , Ernesto Simon , Michael Dalgaard Mikkelsen , Simon Carlsen , Veronique Douchin , Swee Chuang Lim , Louis During
IPC分类号： C12P19/56 , C12N9/10 , C07H15/256
CPC分类号： C12P19/56 , C07H15/256 , C12N9/1051 , C12P15/00 , C12Y204/01
摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.
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公开(公告)号：US20160186225A1
公开(公告)日：2016-06-30
申请号：US14761629
申请日：2014-02-06
申请人： EVOLVA SA
发明人： Michael Dalgaard Mikkelsen , Jorgen Hansen , Ernesto Simon , Frederico Brianza , Angelika Semmler , Kim Olsson , Simon Carlsen , Louis Düring , Alexei Ouspenski , Paula Hicks
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , A23V2002/00 , C12N9/0071 , C12N9/1051 , C12N9/1081 , C12N9/1085 , C12N9/90 , C12N15/81 , C12Y204/01 , C12Y204/99
摘要： Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
摘要翻译： 本发明提供了重组生产甜菊糖苷和含有甜菊糖苷的组合物的方法。
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公开(公告)号：US11041183B2
公开(公告)日：2021-06-22
申请号：US16434202
申请日：2019-06-07
申请人： EVOLVA SA
发明人： Kim Olsson , Ernesto Simon , Michael Dalgaard Mikkelsen , Simon Carlsen , Veronique Douchin , Swee Chuang Lim , Louis During
IPC分类号： C12P19/56 , C12N9/10 , C12P15/00 , C07H15/256
摘要： The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.
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公开(公告)号：US11021727B2
公开(公告)日：2021-06-01
申请号：US16002245
申请日：2018-06-07
申请人： EVOLVA SA
发明人： Ernesto Simon , Iben Nordmark Anderson , Michael Dalgaard Mikkelsen , Jorgen Hansen , Veronique Douchin
摘要： Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes, or that overexpress one or more heterologous transporters, leading to increased excretions of steviol glucosides of interest.
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公开(公告)号：US20170321238A1
公开(公告)日：2017-11-09
申请号：US15439660
申请日：2017-02-22
申请人： Evolva SA
发明人： Jens Houghton-Larsen , Paula Hicks , Michael Naesby , Thomas Tange Ostergaard , Jorgen Hansen , Michael Mikkelsen Dalgaard , Esben Halkjaer Hansen , Ernesto Simon , Sabina Tavares
IPC分类号： C12P19/56 , C12N15/82 , C12N15/81 , C12N15/63 , C12N9/06 , C12N9/88 , C12N9/10 , C12N9/02 , C12P19/44 , C12N9/90
CPC分类号： C12P19/56 , C12N9/0032 , C12N9/0071 , C12N9/0073 , C12N9/1051 , C12N9/1085 , C12N9/88 , C12N9/90 , C12N15/63 , C12N15/81 , C12N15/8243 , C12P19/44 , Y02P20/52
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
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