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公开(公告)号：US20180346953A1
公开(公告)日：2018-12-06
申请号：US15974429
申请日：2018-05-08
申请人： EVOLVA SA
发明人： Yaoquan Liu , Jorgen Hansen , Jens Houghton-Larsen , Muthuswamy Panchapagesa Murali , Sathish Kumar , Nina Nicoline Rasmussen
IPC分类号： C12P33/20 , C12N9/02 , C12P33/12 , C12P33/08 , C12P33/00 , C12P19/56 , C12P19/18 , C12N9/90 , C12N9/14 , C12N9/10 , C12N15/80
CPC分类号： C12P33/20 , C12N9/0071 , C12N9/0073 , C12N9/1048 , C12N9/14 , C12N9/90 , C12N15/80 , C12P19/18 , C12P19/56 , C12P33/00 , C12P33/08 , C12P33/12 , C12Y114/00 , C12Y114/13132 , C12Y303/00 , C12Y504/99033
摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
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公开(公告)号：US09957540B2
公开(公告)日：2018-05-01
申请号：US14761629
申请日：2014-02-06
申请人： Evolva SA
发明人： Michael Dalgaard Mikkelsen , Jorgen Hansen , Ernesto Simon , Federico Brianza , Angelika Semmler , Kim Olsson , Simon Carlsen , Louis Düring , Alexei Ouspenski , Paula Hicks
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , A23V2002/00 , C12N9/0071 , C12N9/1051 , C12N9/1081 , C12N9/1085 , C12N9/90 , C12N15/81 , C12Y204/01 , C12Y204/99
摘要： Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided herein.
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公开(公告)号：US20160186225A1
公开(公告)日：2016-06-30
申请号：US14761629
申请日：2014-02-06
申请人： EVOLVA SA
发明人： Michael Dalgaard Mikkelsen , Jorgen Hansen , Ernesto Simon , Frederico Brianza , Angelika Semmler , Kim Olsson , Simon Carlsen , Louis Düring , Alexei Ouspenski , Paula Hicks
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , A23V2002/00 , C12N9/0071 , C12N9/1051 , C12N9/1081 , C12N9/1085 , C12N9/90 , C12N15/81 , C12Y204/01 , C12Y204/99
摘要： Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
摘要翻译： 本发明提供了重组生产甜菊糖苷和含有甜菊糖苷的组合物的方法。
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公开(公告)号：US20150322473A1
公开(公告)日：2015-11-12
申请号：US14442694
申请日：2013-12-04
申请人： EVOLVA SA
发明人： Yaoquan Liu , Jorgen Hansen , Jens Houghton-Larsen , Muthuswamy Panchapagesa Murali , Sathish Kumar , Nina Nicoline Rasmussen
CPC分类号： C12P33/20 , C12N9/0071 , C12N9/0073 , C12N9/1048 , C12N9/14 , C12N9/90 , C12N15/80 , C12P19/18 , C12P19/56 , C12P33/00 , C12P33/08 , C12P33/12 , C12Y114/00 , C12Y114/13132 , C12Y303/00 , C12Y504/99033
摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
摘要翻译： 本发明涉及借助于酶的方法来生产芒果苷。 特别地，本发明提出了可用于罗汉果苷生产的各种生物合成途径，并提供了可用于罗汉果苷生产的酶。 此外，本发明提供可用于实施本发明方法的重组宿主。
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公开(公告)号：US20240110215A1
公开(公告)日：2024-04-04
申请号：US18470785
申请日：2023-09-20
申请人： EVOLVA SA
发明人： Ganesh M. Kishore , Michael Motion , Paula M. Hicks , Jorgen Hansen , Jens Houghton Larsen , Esben Halkjaer Hansen , Michael Dalgaard Mikkelsen , Sabina Tavares , Charlotte Blom
IPC分类号： C12P19/56 , A23L2/60 , A23L27/30 , C07H15/256 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/82 , C12P7/42 , C12P15/00
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , C07H15/256 , C12N9/0006 , C12N9/0042 , C12N9/0073 , C12N9/1051 , C12N9/1077 , C12N9/1085 , C12N9/88 , C12N9/90 , C12N15/52 , C12N15/8243 , C12N15/8245 , C12P7/42 , C12P15/00 , C12Y101/01088 , C12Y106/02004 , C12Y114/13078 , C12Y114/13079 , C12Y204/01126 , C12Y205/01029 , C12Y402/03019 , C12Y505/01012 , Y02P20/52
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.
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公开(公告)号：US20220073960A1
公开(公告)日：2022-03-10
申请号：US17373612
申请日：2021-07-12
申请人： EVOLVA SA
发明人： Ganesh M. Kishore , Michael Motion , Paula M. Hicks , Jorgen Hansen , Jens Hougton-Larsen , Esben Halkjaer Hansen , Michael Dalgaard Mikkelsen , Sabina Tavares , Charlotte Blom, Sr.
IPC分类号： C12P19/56 , A23L27/30 , C12N15/82 , C12P15/00 , C12N9/10 , A23L2/60 , C07H15/256 , C12N9/04 , C12N9/02 , C12N9/88 , C12N9/90 , C12N15/52 , C12P7/42
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express novel recombinant genes encoding steviol biosynthetic enzymes and UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol or steviol glycosides, e.g., rubusoside or Rebaudioside A, which can be used as natural sweeteners in food products and dietary supplements.
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公开(公告)号：US20220017932A1
公开(公告)日：2022-01-20
申请号：US17244089
申请日：2021-04-29
申请人： EVOLVA SA
发明人： Ernesto Simon , Iben Nordmark Anderson , Michael Dalgaard Mikkelsen , Jorgen Hansen , Veronique Douchin
摘要： Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes, or that overexpress one or more heterologous transporters, leading to increased excretion of steviol glycosides of interest.
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公开(公告)号：US10662458B2
公开(公告)日：2020-05-26
申请号：US15900557
申请日：2018-02-20
申请人： EVOLVA SA
发明人： Yaoquan Liu , Jorgen Hansen , Jens Houghton-Larsen , Muthuswamy Panchapagesa Murali , Sathish Kumar , Nina Nicoline Rasmussen
IPC分类号： C12P19/18 , C12P33/20 , C12N9/10 , C12P19/56 , C12P33/08 , C12N9/02 , C12N9/14 , C12N9/90 , C12P33/00 , C12P33/12 , C12N15/80
摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.
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公开(公告)号：US10435730B2
公开(公告)日：2019-10-08
申请号：US15439660
申请日：2017-02-22
申请人： Evolva SA
发明人： Jens Houghton-Larsen , Paula Hicks , Michael Naesby , Thomas Tange Ostergaard , Jorgen Hansen , Michael Mikkelsen Dalgaard , Esben Hansen Halkjaer , Ernesto Simon , Sabina De Andrade Periera Tavares
IPC分类号： C12P19/56 , C12N9/10 , C12N9/02 , C12N1/21 , C12N9/88 , C12N9/06 , C12N9/90 , C12N15/81 , C12N15/82 , C12P19/44 , C12N15/63
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
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公开(公告)号：US20190203243A1
公开(公告)日：2019-07-04
申请号：US15908214
申请日：2018-02-28
申请人： EVOLVA SA
发明人： Michael Dalgaard Mikkelsen , Jorgen Hansen , Ernesto Simon , Federico Brianza , Angelika Semmler , Kim Olsson , Simon Carlsen , Louis Düring , Alexei Ouspenski , Paula Hicks
CPC分类号： C12P19/56 , A23L2/60 , A23L27/36 , A23V2002/00 , C12N9/0071 , C12N9/1051 , C12N9/1081 , C12N9/1085 , C12N9/90 , C12N15/81 , C12Y204/01 , C12Y204/99
摘要： Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
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