-
公开(公告)号：US20240199596A1
公开(公告)日：2024-06-20
申请号：US18413767
申请日：2024-01-16
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Jesse M. Jacobsen , Tetsuya Kobayashi , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung
IPC: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04
CPC classification number: C07D413/14 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D417/12 , C07D471/04 , C07B2200/05
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：US11976072B2
公开(公告)日：2024-05-07
申请号：US17845534
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Tetsuya Kobayashi , Yasamin Moazami , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung , QingMing Zhu
IPC: C07D487/04 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：US11926628B2
公开(公告)日：2024-03-12
申请号：US17844871
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Jesse M. Jacobsen , Tetsuya Kobayashi , Jonathan William Medley , Yasamin Moazami , Leena B. Patel , Jie Xu , Suet C. Yeung
IPC: C07D471/14 , A61K31/519
CPC classification number: C07D471/14
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：US20230348494A1
公开(公告)日：2023-11-02
申请号：US18181116
申请日：2023-03-09
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , David W. Lin , Jonathan William Medley , Devan Naduthambi , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang , Qingming Zhu
IPC: C07D513/18 , A61K45/06 , C07D513/08 , C07D513/20 , C07D513/22 , C07D519/00 , C07K16/28
CPC classification number: C07D513/18 , A61K45/06 , C07D513/08 , C07D513/20 , C07D513/22 , C07D519/00 , C07K16/2818 , C07K16/2827
Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.
-
公开(公告)号：US11667652B2
公开(公告)日：2023-06-06
申请号：US17094447
申请日：2020-11-10
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , David W. Lin , Jonathan William Medley , Devan Naduthambi , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang , QingMing Zhu
IPC: C07D513/08 , C07D513/10 , C07D513/20 , C07D513/22 , A61K31/553 , A61P35/00 , C07D513/18 , A61K45/06 , C07D519/00 , C07K16/28
CPC classification number: C07D513/18 , A61K45/06 , C07D513/08 , C07D513/20 , C07D513/22 , C07D519/00 , C07K16/2818 , C07K16/2827
Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.
-
Patent Agency Ranking
公开(公告)号：US20230060354A1
公开(公告)日：2023-03-02
申请号：US17845534
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Stephen D. Holmbo , Tetsuya Kobayashi , Yasamin Moazami , Leena B. Patel , Heath A. Weaver , Jie Xu , Suet C. Yeung , QingMing Zhu
IPC: C07D487/04 , C07D519/00
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：US20190008858A1
公开(公告)日：2019-01-10
申请号：US16005111
申请日：2018-06-11
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K31/498 , C07K5/08 , A61K31/10 , C07K5/083 , C07D498/22 , C07D498/16 , C07D403/14 , C07D241/36 , A61K45/06 , A61K38/21 , A61K38/06 , C07K5/087 , A61K31/519 , A61K31/506 , A61K31/4985 , A61K31/4745 , A61K31/401 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
-
公开(公告)号：US09682998B2
公开(公告)日：2017-06-20
申请号：US15188701
申请日：2016-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Britton Kenneth Corkey , Elfatih Elzein , Michael Graupe , Juan Guerrero , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Chandrasekar Venkataramani , Jeff Zablocki
IPC: C07D255/04 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D401/14 , A61K31/53 , A61P25/08 , C07D498/10 , C07D498/04 , C07D263/58 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D265/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D217/26 , C07D413/12 , C07D279/08 , C07D417/12
CPC classification number: C07D498/10 , C07D217/26 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D263/58 , C07D265/22 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/04
Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
-
公开(公告)号：US09403782B2
公开(公告)日：2016-08-02
申请号：US14808296
申请日：2015-07-24
Applicant: Gilead Sciences, Inc.
Inventor： Britton Kenneth Corkey , Elfatih Elzein , Michael Graupe , Juan Guerrero , Robert H. Jiang , Rao V. Kalla , Tetsuya Kobayashi , Dmitry Koltun , Xiaofen Li , Ruben Martinez , Gregory Notte , Eric Q. Parkhill , Thao Perry , Chandrasekar Venkataramani , Jeff Zablocki
IPC: C07D237/30 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/06 , C07D413/14 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/4427 , A61P25/08 , C07D253/08 , C07D498/04 , C07D263/58 , C07D237/32 , C07D239/88 , C07D239/90 , C07D265/22 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/06 , C07D417/14 , C07D217/26 , C07D413/12 , C07D498/10
CPC classification number: C07D498/10 , C07D217/26 , C07D237/32 , C07D239/88 , C07D239/90 , C07D253/08 , C07D263/58 , C07D265/22 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/04
Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
-
公开(公告)号：US09296782B2
公开(公告)日：2016-03-29
申请号：US13934090
申请日：2013-07-02
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K6/00 , C07K1/00 , C07K5/08 , C07D498/16 , A61K31/4985 , C07D498/22 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K45/06 , C07K5/087 , C07K5/083 , A61K38/21 , A61K38/06 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
Abstract translation: 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
-
-
-
-
-
-
-
-
-
Search Results
55
records
(took 0.053 seconds)
