公开(公告)号：US20250136621A1

公开(公告)日：2025-05-01

申请号：US19000200

申请日：2024-12-23

Applicant: Gilead Sciences, Inc.

Inventor： Chaodi Dai ,  Juan A. Guerrero ,  Darryl Kato ,  Scott E. Lazerwith ,  Jonathan William Medley ,  Thomas C.J. Mies ,  Hyung-Jung Pyun ,  Hayato Shiotsu ,  Maoqun Tian ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/55

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US20250109147A1

公开(公告)日：2025-04-03

申请号：US18827510

申请日：2024-09-06

Applicant: Gilead Sciences, Inc.

Inventor： Chaodi Dai ,  Juan A. Guerrero ,  Darryl Kato ,  Scott E. Lazerwith ,  Jonathan William Medley ,  Thomas C.J. Mies ,  Hyung-Jung Pyun ,  Hayato Shiotsu ,  Maoqun Tian ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/55

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US20250101042A1

公开(公告)日：2025-03-27

申请号：US18825960

申请日：2024-09-05

Applicant: Gilead Sciences, Inc.

Inventor： Wilian Augusto Cortopassi Coelho ,  Chaodi Dai ,  Juan A. Guerrero ,  Hongyan Guo ,  Darryl Kato ,  Scott E. Lazerwith ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Maoqun Tian ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/55

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US12202842B2

公开(公告)日：2025-01-21

申请号：US18181116

申请日：2023-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  Qingming Zhu

IPC: C07D413/08 ,  A61K31/553 ,  A61K45/06 ,  A61P35/00 ,  C07D513/08 ,  C07D513/10 ,  C07D513/18 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  C07K16/28

Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US12187753B2

公开(公告)日：2025-01-07

申请号：US18236532

申请日：2023-08-22

Applicant: Gilead Sciences, Inc.

Inventor： Julie Farand ,  Tezcan Guney ,  Darryl Kato ,  John O. Link ,  James B. C. Mack ,  William J. Watkins

IPC: C07F9/09

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US20240383922A1

公开(公告)日：2024-11-21

申请号：US18631866

申请日：2024-04-10

Applicant: Gilead Sciences, Inc.

Inventor： Wilian Augusto Cortopassi Coelho ,  Chaodi Dai ,  Katherine De La Fuente ,  Julie Farand ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Safaa S. Jamshed ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  James B.C. Mack ,  Joshua L. Martin ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Thomas P. Stratton ,  Rhiannon Thomas-Tran ,  Maoqun Tian ,  Vickie H. Tsui ,  William J. Watkins ,  Jie Xu ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/553 ,  A61K45/06

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US11905299B2

公开(公告)日：2024-02-20

申请号：US17317041

申请日：2021-05-11

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D401/12 ,  C07D498/04 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D401/14 ,  C07B59/00

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07B2200/05

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20230348494A1

公开(公告)日：2023-11-02

申请号：US18181116

申请日：2023-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  Qingming Zhu

IPC: C07D513/18 ,  A61K45/06 ,  C07D513/08 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D513/18 ,  A61K45/06 ,  C07D513/08 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US11667652B2

公开(公告)日：2023-06-06

申请号：US17094447

申请日：2020-11-10

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC: C07D513/08 ,  C07D513/10 ,  C07D513/20 ,  C07D513/22 ,  A61K31/553 ,  A61P35/00 ,  C07D513/18 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D513/18 ,  A61K45/06 ,  C07D513/08 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20210323922A1

公开(公告)日：2021-10-21

申请号：US17098171

申请日：2020-11-13

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Todd Appleby ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Juan A. Guerrero ,  Salman Y. Jabri ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Gregory Notte ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Chandrasekar Venkataramani ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D213/69 ,  A61K45/06 ,  A61K31/444 ,  C07D401/14 ,  A61K31/5377 ,  C07D213/85 ,  A61K31/44 ,  C07D213/30 ,  C07D295/088 ,  A61K31/4545 ,  C07D401/04 ,  A61K31/497 ,  C07D519/00 ,  C07D487/10 ,  C07D487/08 ,  C07D213/64 ,  C07D491/107 ,  C07D498/04 ,  C07D213/61 ,  C07D405/14

Abstract: Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.