-
21.发明授权Method for enhancing therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases 有权增强干细胞对自身免疫性疾病，心血管疾病和/或血液疾病的治疗效果的方法公开(公告)号：US09523081B2
公开(公告)日：2016-12-20
申请号：US14821309
申请日：2015-08-07
Inventor： Shinn-Zong Lin , Horng-Jyh Harn , Ru-Huei Fu , Shih-Ping Liu , Po-Cheng Lin , Ming-Hsi Chuang
IPC: A01N63/00 , A01N65/00 , C12N5/0775 , A61K35/545 , A61K35/28
CPC classification number: A61K35/28 , A61K31/365 , A61K35/545 , C12N5/0667 , C12N2501/40 , C12N2501/999
Abstract: A method for enhancing the therapeutic effect of a stem cell on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject suffering from autoimmune diseases, cardiovascular diseases, and/or hematological diseases an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide.
Abstract translation: 提供了一种用于增强干细胞对自身免疫性疾病，心血管疾病和/或血液疾病的治疗效果的方法。 该方法包括用罗替司特治疗干细胞，其中处理在干细胞的培养基中进行。 还提供了一种干细胞治疗方法，其包括对患有自身免疫性疾病，心血管疾病和/或血液疾病的受试者施用有效量的干细胞或光灭活素与干细胞的组合，其中所述干细胞具有 用ligustilide治疗。
-
公开(公告)号：US20240124844A1
公开(公告)日：2024-04-18
申请号：US18376459
申请日：2023-10-04
Inventor： Chia-Hsin Lee , Po-Cheng Lin , Yong-Cheng Kao , Ming-Hsi Chuang , Chun-Hung Chen , Chao-Liang Chang , Kai-Ling Zhang
IPC: C12N5/0775 , A61P19/02
CPC classification number: C12N5/0667 , A61P19/02 , C12N2500/32 , C12N2500/38 , C12N2501/10
Abstract: The present disclosure provides a method for preparing a composition including mesenchymal stem cells, extracellular vesicles produced by the mesenchymal stem cells, and growth factors, the composition prepared by the method, and use of the composition for treating arthritis. The composition of the present disclosure achieves the effect of treating arthritis through various efficacy experiments.
-
Patent Agency Ranking
公开(公告)号：US20230233615A1
公开(公告)日：2023-07-27
申请号：US18097509
申请日：2023-01-17
Inventor： Chi-Ying Huang , Yu-Chen Tsai , Ming-Hsi Chuang , Po-Cheng Lin
IPC: A61K35/28 , A61P25/28 , C12N15/113 , C12N9/64 , C12N5/0775
CPC classification number: A61K35/28 , A61P25/28 , C12N5/0667 , C12N9/6494 , C12N15/113 , C12Y304/24011 , C12N2310/141 , C12N2310/531 , C12N2500/32 , C12N2500/42
Abstract: The present disclosure provides a pharmaceutical composition for treating Alzheimer’s disease, which at least includes an extracellular vesicle that is prepared by a method including: a first culturing step: performing an amplification culture of an adipose-derived stem cell in a first culture medium at a cell density of 6,000-15,000 cells/cm2 until an amplification amount of the adipose-derived stem cell is above 90% of that before the culture; a second culturing step: culturing the amplified adipose-derived stem cell in a second culture medium at a cell density of 10,000-100,000 cells/cm2 for 20-30 hours; and an extracellular vesicle separating step: collecting a culture solution and separating the extracellular vesicle from the culture solution by utilizing a tangential flow filtration (TFF) or ultrafiltration method.
-
公开(公告)号：US20190136195A1
公开(公告)日：2019-05-09
申请号：US16237399
申请日：2018-12-31
Inventor： Shao-Chih Chiu , Wan-Sin Syu , Ming-Hsi Chuang , Po-Cheng Lin
IPC: C12N5/0775 , A61K35/28
Abstract: A composition for treatment of tendonitis is provided. The composition comprises a pretreated adipose derived stem cell (ADSC), wherein the ADSC is pretreated with butylidenephthalide, and the concentration of butylidenephthalide is greater or equal to. The composition of the invention has abilities to repair damaged tendon fiber, enhance tissue regeneration, and decrease inflammation. The invention also provides a method for manufacturing a composition for treatment of tendonitis, comprising culturing an ADSC in a medium containing butylidenephthalide.
-
公开(公告)号：US20180127722A1
公开(公告)日：2018-05-10
申请号：US15416502
申请日：2017-01-26
Inventor： Shao-Chih Chiu , Wan-Sin Syu , Ming-Hsi Chuang , Po-Cheng Lin
IPC: C12N5/0775 , A61K35/28
CPC classification number: C12N5/0667 , A61K35/28 , C12N2500/30 , C12N2500/76
Abstract: A composition for treatment of tendonitis is provided. The composition comprises a pretreated adipose derived stem cell (ADSC), wherein the ADSC is pretreated with butylidenephthalide, and the concentration of butylidenephthalide is greater or equal to. The composition of the invention has abilities to repair damaged tendon fiber, enhance tissue regeneration, and decrease inflammation. The invention also provides a method for manufacturing a composition for treatment of tendonitis, comprising culturing an ADSC in a medium containing butylidenephthalide.
-
公开(公告)号：US20160303168A1
公开(公告)日：2016-10-20
申请号：US14552014
申请日：2014-11-24
Inventor： Shinn-Zong LIN , Horng-Jyh Harn , Ru-Huei Fu , Shih-Ping Liu , Po-Cheng Lin , Ming-Hsi Chuang
IPC: A61K35/28 , A61K31/365 , C12N5/0775
CPC classification number: A61K35/28 , A61K31/365 , A61K35/545 , C12N5/0667 , C12N2501/40 , C12N2501/999
Abstract: A method for enhancing the therapeutic effect of a stem cell is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject in need an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide
Abstract translation: 提供了增强干细胞治疗效果的方法。 该方法包括用罗替司特治疗干细胞，其中处理在干细胞的培养基中进行。 还提供了一种干细胞治疗方法，其包括向有需要的受试者施用有效量的干细胞或罗替司肽与干细胞的组合，其中所述干细胞已用罗替司列
-
27.发明申请METHOD FOR ENHANCING THERAPEUTIC EFFECT OF STEM CELLS ON AUTOIMMUNE DISEASES, CARDIOVASCULAR DISEASES, AND/OR HEMATOLOGICAL DISEASES 有权干细胞治疗自身免疫性疾病，心血管疾病和/或血液病的治疗方法公开(公告)号：US20160075999A1
公开(公告)日：2016-03-17
申请号：US14821309
申请日：2015-08-07
Inventor： Shinn-Zong LIN , Horng-Jyh Harn , Ru-Huei Fu , Shih-Ping Liu , Po-Cheng Lin , Ming-Hsi Chuang
IPC: C12N5/0775 , A61K35/28 , A61K35/545
CPC classification number: A61K35/28 , A61K31/365 , A61K35/545 , C12N5/0667 , C12N2501/40 , C12N2501/999
Abstract: A method for enhancing the therapeutic effect of a stem cell on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject suffering from autoimmune diseases, cardiovascular diseases, and/or hematological diseases an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide.
Abstract translation: 提供了一种用于增强干细胞对自身免疫性疾病，心血管疾病和/或血液疾病的治疗效果的方法。 该方法包括用罗替司特治疗干细胞，其中处理在干细胞的培养基中进行。 还提供了一种干细胞治疗方法，其包括对患有自身免疫性疾病，心血管疾病和/或血液疾病的受试者施用有效量的干细胞或光灭活素与干细胞的组合，其中所述干细胞具有 用ligustilide治疗。
-
-
-
-
-
-
Search Results
27
records
(took 0.021 seconds)
