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31 条记录 (耗时 0.054 秒)

    SUBSTITUTED NAPHTHYRIDINES AND USE THEREOF AS MEDICINES
    23.
    发明申请
    SUBSTITUTED NAPHTHYRIDINES AND USE THEREOF AS MEDICINES 审中-公开
    取代的萘啶酮及其作为药物的用途

    公开(公告)号：US20110201608A1

    公开(公告)日：2011-08-18

    申请号：US13057288

    申请日：2009-07-23

    申请人： Matthias Hoffmann ,  Thierry Bouyssou ,  Georg Dahamnn ,  Harald Engelhardt ,  Dennis Fiegen ,  Sandra Handschum ,  Silke Hobbie ,  Takeshi Kono ,  Ulrich Reiser ,  Yayoi Sato ,  Andreas Schnapp ,  Annette Schuler-Metz

    发明人： Matthias Hoffmann ,  Thierry Bouyssou ,  Georg Dahamnn ,  Harald Engelhardt ,  Dennis Fiegen ,  Sandra Handschum ,  Silke Hobbie ,  Takeshi Kono ,  Ulrich Reiser ,  Yayoi Sato ,  Andreas Schnapp ,  Annette Schuler-Metz

    IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/496 ,  A61P11/06 ,  A61P19/02 ,  A61P1/04 ,  A61P17/06 ,  A61P35/00 ,  A61P17/00 ,  A61P11/00

    CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04

    摘要： The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 denotes a group A selected from among —O—R3, —NR3R4, —CR3R4R5, -(ethyne)-R3, —S—R3, —SO—R3 and SO2—R3 or R1 denotes a group B selected from among C6-10-aryl, five- to ten-membered, mono- or bicyclic heteroaryl with 1-3 heteroatoms selected independently of one another from among N, O and S; while this heteroaryl is linked to the structure according to formula 1 via either a C atom or an N atom, three- to ten-membered, mono- or bicyclic, saturated or partially saturated heterocyclic group with 1-3 heteroatoms selected independently of one another from among N, O and S, while this heterocyclic group is linked to the structure according to formula 1 via either a C atom or an N atom, and 5- to 11-membered spiro group which may optionally contain 1, 2 or 3 heteroatoms selected independently of one another from among N, O and S, while this spiro group is linked to the structure according to formula 1 via either a C atom or an N atom, while this group B may optionally be substituted as described in claim 1 and wherein R2 is and R3, R4, R5, R6, R6′, R7, R8, R9, R10, V, n and m may have the meanings given in claim 1, as well as pharmaceutical compositions containing these compounds.

    摘要翻译： 本发明涉及式1的新取代的萘啶，以及其药学上可接受的盐，非对映异构体，对映异构体，外消旋体，水合物或溶剂化物，其中R1表示选自-O-R3，-NR3R4，-CR3R4R5， （乙炔）-R 3，-S-R 3，-SO-R 3和SO 2 -R 3或R 1表示选自C 6-10 - 芳基，5至10元，单 - 或双环杂芳基和1-3 从N，O和S中彼此独立地选择的杂原子; 而该杂芳基通过C原子或N原子连接到根据式1的结构，具有1-3个互相独立选择的杂原子的三至十元，单环或二环，饱和或部分饱和的杂环基 N，O和S中的至少一个，而该杂环基通过C原子或N原子与根据式1的结构连接，并且可以任选地含有1,2或3个杂原子的5至11元螺环 N，O和S彼此独立地选择，而该螺环通过C原子或N原子连接到根据式1的结构，而该基团B可以任选地被如权利要求1和 其中R2是和R3，R4，R5，R6，R6'，R7，R8，R9，R10，V，n和m可以具有权利要求1中给出的含义，以及含有这些化合物的药物组合物。

    Motor vehicle
    26.
    发明申请
    Motor vehicle 审中-公开
    摩托车

    公开(公告)号：US20060276950A1

    公开(公告)日：2006-12-07

    申请号：US10549058

    申请日：2004-03-12

    申请人： Horst Wild ,  Klaus Wohlrab ,  Harald Engelhardt

    发明人： Horst Wild ,  Klaus Wohlrab ,  Harald Engelhardt

    IPC分类号： G06F17/00

    CPC分类号： F16H61/0213 ,  F16H59/48 ,  F16H61/0248 ,  F16H63/42 ,  F16H2059/084 ,  F16H2059/085 ,  F16H2061/0227 ,  F16H2300/14

    摘要： Disclosed is a motor vehicle with an automatic gearbox, a gearbox control unit comprising several driving programs which control the gear switching operation and a selection lever for manual selection between a normal D driving program with automatic gearbox adjustment and a sporty S driving program. The motor vehicle also includes automatic gearbox adjustment and/or a manual driving program with manual gearbox adjustment. The gearbox control unit (3) is designed to automatically change from the S driving program or the manual driving program to the D driving program, depending on at least one operating parameter of the vehicle (1).

    摘要翻译： 公开了一种具有自动变速箱的机动车辆，包括控制齿轮切换操作的多个驾驶程序的变速箱控制单元和用于在具有自动变速箱调节的正常D驾驶程序和运动S驾驶程序之间进行手动选择的选择杆。 机动车辆还包括自动变速箱调整和/或手动变速箱调整的手动驾驶程序。 齿轮箱控制单元（3）被设计成根据车辆（1）的至少一个操作参数自动地从S驱动程序或手动驾驶程序切换到D驾驶程序。

    Apparatus for the determination of the partial pressure of gases dissolved in a fluid
    28.
    发明授权
    Apparatus for the determination of the partial pressure of gases dissolved in a fluid 失效
    用于确定流体中溶解气体的部分压力的装置

    公开(公告)号：US5058416A

    公开(公告)日：1991-10-22

    申请号：US293620

    申请日：1989-01-05

    申请人： Harald Engelhardt ,  Guenter Rau ,  Helmut Reul

    发明人： Harald Engelhardt ,  Guenter Rau ,  Helmut Reul

    IPC分类号： G01N33/49 ,  A61B5/00 ,  A61B5/145 ,  G01N7/10 ,  G01N27/27 ,  G01N33/18 ,  G01N33/497

    CPC分类号： A61B5/145 ,  A61B5/14528

    摘要： An apparatus for determining the partial pressure of a gas dissolved in a fluid which includes a catheter consisting of a double bored coaxial catheter having an outer tube and a spaced coaxial inner tube, the outer tube being permeable to the gas being measured, together with a pump for delivering a continuous flow of a carrier fluid into the space between the inner tube and the outer tube. A measuring device is located downstream of the catheter for determining the partial pressure of the gas in the carrier fluid. A mass transfer unit receives the gas after the measuring device and is arranged to bring the partial pressure of the gas in the carrier fluid to a predetermined value.

    摘要翻译： 一种用于确定溶解在流体中的气体的分压的装置，其包括由具有外管和间隔开的同轴内管的双孔同轴导管组成的导管，所述外管对被测量的气体是可透过的， 泵，用于将载流体的连续流动输送到内管和外管之间的空间中。 测量装置位于导管的下游，用于确定载液中气体的分压。 质量传递单元接收测量装置之后的气体并且被布置成使载体流体中的气体的分压达到预定值。