Abstract:
Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate. The long-term implantable fluid monitoring system thus includes a first porous catheter, a second porous catheter, a sensor configured to measure an amount of analyte in fluid, and a pump configured to move fluid through the first porous catheter to the sensor and from the sensor through the second porous catheter.
Abstract:
The present disclosure relates to a molecular exchange device. In particular, the molecular exchange device comprises at least one fluid passageway and an actuator, the actuator positioned to provide a secondary fluid pathway within at least one of the fluid passageways.
Abstract:
The invention relates to a method and arrangement for continuously measuring substances in a pressurised body fluid. A probe (202) for enabling continuous measurement of the concentration of one or more substances in a pressurized body fluid is provided. The probe is adapted to be inserted into the pressurized body fluid, and comprises an interface and an outlet lumen. Furthermore, the probe is configured so that a continuous and spontaneous fluid flow is established from the body fluid through the interface to the outlet lumen. The fluid flow from the outlet may be analyzed by a sensor.
Abstract:
Fluid sampling apparatus 10 comprising an elongate tube 14 and a fluid partitioning unit 12 comprising: a first port 18 arranged to receive an incoming flow of test fluid TF; and a second port 20 arranged to be coupled to the elongate tube. The fluid partitioning unit is arranged to combine the flow of test fluid with a plurality of partitioning elements 26 to define a plurality of discrete temporally organised fluid samples FS for movement along and storage in the elongate tube.
Abstract:
A sensor is provided available for continuous monitoring of regional blood flow in a tissue, including cerebral tissue. Methods of monitoring regional blood flow using the sensor as well as systems and computer readable medium therefor are also provided.
Abstract:
Sampling device for obtaining a sample of an analyte, comprising a feed line (30) and a discharge line (40) as well as an analyte feed chamber (13) in fluidic connection between the feed line and the discharge line, the analyte feed chamber having an opening (14) which is provided with an analyte-permeable membrane (15) to allow the analyte to pass through from a region outside the analyte feed chamber into the analyte feed chamber, the surface area of the opening of the analyte feed chamber being at most 400 times the minimum cross-sectional surface area of the discharge line, more preferably at most 100 times and most preferably 50 to 80 times the minimum cross-sectional surface area of the discharge line. This device will reduce the dead time between the passage of the analyte through the membrane and the detection of said analyte at the sensor.
Abstract:
Among others, the present invention provides apparatus for detecting circulating tumor cells, comprising a system delivery biological subject and a probing and detecting device, wherein the probing and detecting device includes a first micro-device and a first substrate supporting the first micro-device, the first micro-device contacts a biologic material to be detected and is capable of measuring at the microscopic level an electrical, magnetic, electromagnetic, thermal, optical, acoustical, biological, chemical, electro-mechanical, electro-chemical, electro-optical, electro-thermal, electro-chemical-mechanical, bio-chemical, bio-mechanical, bio-optical, bio-thermal, bio-physical, bio-electro-mechanical, bio-electro-chemical, bio-electro-optical, bio-electro-thermal, bio-mechanical-optical, bio-mechanical thermal, bio-thermal-optical, bio-electro-chemical-optical, bio-electro-mechanical-optical, bio-electro-thermal-optical, bio-electro-chemical-mechanical, physical or mechanical property, or a combination thereof, of the biologic subject.
Abstract:
A dialysis probe includes a tubular dialysis membrane sealed at its tip, a support tube coupled at a tip to a rear end of the dialysis membrane, a cap portion for securing a rear end of the support tube, an inlet conduit extending through the cap portion toward the tip of the dialysis membrane within a space to guide a perfusate into the space, an outlet conduit extending through the cap portion toward the tip of the dialysis membrane within the space to guide the perfusate in the space outside the space, and at least one air-exposure through-hole provided in the cap portion for maintaining the space at atmospheric pressure. The inlet conduit has a longer protruding length from the rear end of the support tube when compared to the outlet conduit.
Abstract:
The present invention provides apparatuses, systems, and methods for real-time measuring of analytes in a biological fluid sample of a subject. In particular, the present invention provides a combination of micro-dialysis catheter, a micro-volume pump, and a spectrometer device that are operatively connected to one another to provide real-time measurement of analytes in a biological fluid sample of a subject.
Abstract:
Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.