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公开(公告)号：US06608049B2
公开(公告)日：2003-08-19
申请号：US09956566
申请日：2001-09-18
申请人： Michael Woltering , Helmut Haning , Gunter Schmidt , Josef Pernerstorfer , Hilmar Bischoff , Axel Kretschmer , Verena Vöhringer , Christiane Faeste
发明人： Michael Woltering , Helmut Haning , Gunter Schmidt , Josef Pernerstorfer , Hilmar Bischoff , Axel Kretschmer , Verena Vöhringer , Christiane Faeste
IPC分类号： A61K314162
CPC分类号： A61K45/06 , C07D231/56
摘要： The invention relates to new indazole derivatives, processes for their preparation, and their use in medicaments.
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![Indanyl-substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them](/abs-image/US/2015/05/19/US09034897B2/abs.jpg.150x150.jpg)
22.发明授权Indanyl-substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them 有权茚基取代的4,5,6,7-四氢-1H-吡唑并[4,3-C]吡啶，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US09034897B2
公开(公告)日：2015-05-19
申请号：US14342749
申请日：2011-09-12
IPC分类号： C07D401/14 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D401/14
摘要： The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译： 本发明涉及式（I）的取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂。 式（I）化合物作用于TASK-1钾通道。 该化合物特别适用于治疗或预防房性心律失常，例如房颤（AF）或心房扑动。
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公开(公告)号：US07615557B2
公开(公告)日：2009-11-10
申请号：US10574122
申请日：2004-09-22
申请人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi , Hiroaki Yuasa , Jang Gupta , Fumihiko Hayashi
发明人： Axel Bouchon , Nicole Diedrichs , Achim Hermann , Klemens Lustig , Heinrich Meier , Josef Pernerstorfer , Elke Reissmuller , Jean De Vry , Muneto Mogi , Klaus Urbahns , Takeshi Yura , Hiroshi Fujishima , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi , Hiroaki Yuasa , Jang Gupta , Fumihiko Hayashi
IPC分类号： A01N43/40 , A61K31/445 , A61K31/4965 , C07D295/00 , C07D241/04
CPC分类号： C07D295/215 , C07D211/62 , C07D401/04
摘要： This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.
摘要翻译： 本发明涉及用作药物制剂活性成分的羟基 - 四氢 - 萘或脲衍生物式（I）及其盐，其中A表示式（II）或（III），其中＃表示与 分子和Q1a，Q2a，Q3a和Q4a，E表示式（IV）或（V），其中＃表示与分子的连接位置，Q1b，Q2b，Q3b，Q4b，Q5b，R1b，na，ma，Xa 和Ra。
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24.发明授权公开(公告)号：US07544709B2
公开(公告)日：2009-06-09
申请号：US10496058
申请日：2002-11-07
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada
IPC分类号： A61K31/4015 , C07D207/40
CPC分类号： C07D207/40
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, particularly bacterial infections diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法，含有它们的药物组合物，以及它们在人或动物疾病，特别是细菌感染疾病的治疗和/或前体中的应用。 这些化合物是天然物质和杀虫剂和莫拉滨B的衍生物。
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公开(公告)号：US07348357B2
公开(公告)日：2008-03-25
申请号：US10524080
申请日：2003-07-28
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/4015 , C07D207/12
CPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在治疗和/或预防人或动物特别是细菌感染疾病中的用途。
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公开(公告)号：US20060173040A1
公开(公告)日：2006-08-03
申请号：US10524080
申请日：2003-07-28
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Peter Nell , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Schiffer , Mitsuyuki Shimada , Niels Svenstrup , Rainer Endermann
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/422 , C07D409/02 , C07D405/02 , C07D403/02
CPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.
摘要翻译： 本发明涉及化合物，其制备方法，包含它们的药物组合物，以及它们在治疗和/或预防人或动物特别是细菌感染疾病中的用途。
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27.发明申请公开(公告)号：US20050080129A1
公开(公告)日：2005-04-14
申请号：US10496058
申请日：2002-11-07
申请人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Shiffer , Mitsuyuki Shimada
发明人： Nina Brunner , Christoph Freiberg , Thomas Lampe , Ben Newton , Michael Otteneder , Josef Pernerstorfer , Jens Pohlmann , Guido Shiffer , Mitsuyuki Shimada
IPC分类号： C07D401/12 , A61K31/4015 , A61K31/4025 , A61K31/4709 , A61K31/5377 , A61P1/02 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/00 , A61P27/02 , A61P31/00 , A61P31/04 , C07D207/40 , C07D405/12 , C07D43/02
CPC分类号： C07D207/40
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法，含有它们的药物组合物及其在人或动物疾病的治疗和/或前体疾病中的用途。 这些化合物是天然物质和杀虫剂和莫拉滨B的衍生物。
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公开(公告)号：US06555580B2
公开(公告)日：2003-04-29
申请号：US09918741
申请日：2001-07-31
申请人： Helmut Haning , Josef Pernerstorfer , Gunter Schmidt , Michael Woltering , Hilmar Bischoff , Verena Vöhringer , Axel Kretschmer , Christiane Faeste
发明人： Helmut Haning , Josef Pernerstorfer , Gunter Schmidt , Michael Woltering , Hilmar Bischoff , Verena Vöhringer , Axel Kretschmer , Christiane Faeste
IPC分类号： C07C23301
CPC分类号： C07D295/215 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/56 , C07C233/60 , C07C233/73 , C07C233/75 , C07C235/16 , C07C235/24 , C07C235/60 , C07C235/62 , C07C237/30 , C07C271/28 , C07C275/36 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D223/10 , C07D307/14 , C07D307/52 , C07D311/24 , C07D333/38
摘要： The invention relates to novel amino- and amido-diphenyl ethers, processes for their preparation and their use in pharmaceuticals, in particular for the indications of arteriosclerosis and hypercholesterolaemia.
摘要翻译： 本发明涉及新的氨基和酰氨基二苯基醚，其制备方法及其在药物中的用途，特别是用于动脉硬化和高胆固醇血症的适应症。
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![Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them](/abs-image/US/2015/09/08/US09127001B2/abs.jpg.150x150.jpg)
29.发明授权Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them 有权取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US09127001B2
公开(公告)日：2015-09-08
申请号：US14342744
申请日：2011-09-16
申请人： Laurent Bialy , Katrin Lorenz , Klaus Wirth , Klaus Steinmeyer , Gerhard Hessler , Josef Pernerstorfer , Joachim Brendel
发明人： Laurent Bialy , Katrin Lorenz , Klaus Wirth , Klaus Steinmeyer , Gerhard Hessler , Josef Pernerstorfer , Joachim Brendel
IPC分类号： C07D513/02 , C07D471/04 , C07D471/18
CPC分类号： C07D471/04 , C07D471/18
摘要： The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
摘要翻译： 本发明涉及式（I）的取代的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶，它们作为药物的用途，以及包含它们的药物制剂。 式（I）化合物作用于TASK-1钾通道。 该化合物特别适用于治疗或预防房性心律失常，例如房颤（AF）或心房扑动。
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30.发明申请OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS 有权氧自由基取代的3-异丁酰氨基酸衍生物及其作为药物的用途公开(公告)号：US20130046004A1
公开(公告)日：2013-02-21
申请号：US13575008
申请日：2011-01-26
申请人： Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Thomas Olpp , Bodo Scheiper , Klaus Wirth
发明人： Sven Ruf , Josef Pernerstorfer , Thorsten Sadowski , Georg Horstick , Herman Schreuder , Christian Buning , Thomas Olpp , Bodo Scheiper , Klaus Wirth
IPC分类号： C07D231/22 , C07C229/08 , A61K31/216 , C07D405/12 , A61K31/4155 , C07D403/12 , A61P9/10 , A61P9/00 , A61P29/00 , A61P11/00 , A61P11/06 , A61P37/00 , A61P7/10 , A61P25/28 , A61P13/12 , A61P7/02 , A61P19/02 , A61K31/4152
CPC分类号： C07C229/36 , C07D231/20 , C07D231/22 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I化合物，其中A，D，E，G，R 10，R 30，R 40，R 50和R 60具有权利要求中所示的含义，它们是有价值的药物活性化合物。 它们是蛋白酶组织蛋白酶A的抑制剂，例如可用于治疗动脉粥样硬化，心力衰竭，肾脏疾病，肝脏疾病或炎性疾病等疾病。 本发明还涉及制备式I化合物的方法，其用途和包含它们的药物组合物。
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