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56 条记录 (耗时 0.057 秒)

    Polypeptide
    21.
    发明授权
    Polypeptide 有权
    多肽

    公开(公告)号：US07241605B1

    公开(公告)日：2007-07-10

    申请号：US09914152

    申请日：2000-02-24

    申请人： Hisashi Narimatsu ,  Soichiro Isshiki ,  Akira Togayachi ,  Katsutoshi Sasaki

    发明人： Hisashi Narimatsu ,  Soichiro Isshiki ,  Akira Togayachi ,  Katsutoshi Sasaki

    IPC分类号： C12N9/10

    CPC分类号： C12N9/1051 ,  A61K38/00 ,  A61K39/00 ,  C12P19/04

    摘要： According to the present invention, there can be provided a novel polypeptide having β1,3-galactosyltransferase activity involved in the synthesis of type 1 sugar chains, a DNA coding for said polypeptide, a recombinant vector comprising said DNA, a transformant carrying said recombinant vector, a process for producing type 1 sugar chain-containing sugar chains and complex carbohydrates by use of said polypeptide or said transformant, an antibody recognizing said polypeptide, a method for detecting or quantifying said polypeptide by use of said antibody, a method for screening a substance correlated with said polypeptide, a method for diagnosis or treatment of cancers in the digestive system by use of said DNA or said antibody, and a method for treatment of cancers in the digestive system by use of a substance obtained by said screening method.

    摘要翻译： 根据本发明，可以提供一种具有参与1型糖链合成的β1,3-半乳糖基转移酶活性的新型多肽，编码所述多肽的DNA，包含所述DNA的重组载体，携带所述重组载体的转化体 ，通过使用所述多肽或所述转化体产生含有1号糖链的糖链和复合碳水化合物的方法，识别所述多​​肽的抗体，通过使用所述抗体检测或定量所述多肽的方法，筛选 与所述多肽相关的物质，通过使用所述DNA或所述抗体在消化系统中诊断或治疗癌症的方法，以及通过使用通过所述筛选方法获得的物质来治疗消化系统中的癌症的方法。

    Method of detecting bone paget's disease
    22.
    发明申请
    Method of detecting bone paget's disease 审中-公开
    检测骨佩吉特氏病的方法

    公开(公告)号：US20060141463A1

    公开(公告)日：2006-06-29

    申请号：US10534002

    申请日：2003-11-07

    申请人： Hisashi Narimatsu ,  Takashi Sato ,  Masanori Gotoh

    发明人： Hisashi Narimatsu ,  Takashi Sato ,  Masanori Gotoh

    IPC分类号： C12Q1/68 ,  A01K67/027

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C12N9/13 ,  C12N9/16 ,  C12N15/8509 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： A method for detecting Paget disease of bone and an animal showing the pathology of Paget disease of bone are provided. In particular, there are provided associating Paget disease of bone with the mutation a chondroitin/chondroitin synthase gene comprising the amino acid sequence depicted in any one of SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 66, SEQ ID NO: 68 or SEQ ID NO: 70 or the amount of expression of said gene, detection of Paget disease of bone, and a knockout animal prepared by knocking out the chondroitin/chondroitin synthase gene.

    摘要翻译： 本发明提供了一种检测骨代谢性疾病的方法和显示骨折佩吉特病变的动物。 具体地说，提供骨关节性Paget疾病与突变的软骨素/软骨素合成酶基因，其包含SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：6中任一项所示的氨基酸序列 NO：66，SEQ ID NO：68或SEQ ID NO：70或所述基因的表达量，骨的Paget病的检测以及通过敲除软骨素/软骨素合成酶基因制备的敲除动物。

    N-acetylgalactosamine transferases and nucleic acids encoding the same
    27.
    发明授权
    N-acetylgalactosamine transferases and nucleic acids encoding the same 失效
    N-乙酰半乳糖胺转移酶和编码相同的核酸

    公开(公告)号：US07494800B2

    公开(公告)日：2009-02-24

    申请号：US10524505

    申请日：2003-08-13

    申请人： Hisashi Narimatsu ,  Masanori Gotoh ,  Takashi Sato

    发明人： Hisashi Narimatsu ,  Masanori Gotoh ,  Takashi Sato

    IPC分类号： C12N15/54 ,  C12N15/63 ,  C12N1/21 ,  C12N9/10

    CPC分类号： C12N9/1051 ,  G01N33/57484

    摘要： An enzyme which transfers N-acetylgalactosamine to N-acetylglucosamine via a β1-4 linkage was isolated and the structure of its gene was explained. This led to the production of said enzyme or the like by genetic engineering techniques, the production of oligosaccharides using said enzyme, and the diagnosis of diseases on the basis of said gene or the like. The present invention uses a protein having the amino acid sequence shown in SEQ ID NO: 1, 3, 26 or 27 in the Sequence Listing or a variant of said amino acid sequence wherein one or more acids are substituted or deleted, or one or more acids are inserted or added and having the activity of transferring N-acetylgalactosamine (GalNAc) to N-acetylglucosamine serving as a substrate via a β1-4 linkage and nucleic acids encoding said protein.

    摘要翻译： 分离通过β1-4键将N-乙酰半乳糖胺转移到N-乙酰葡糖胺的酶，并解释其基因的结构。 这导致通过基因工程技术生产所述酶等，使用所述酶生产寡糖，以及基于所述基因等诊断疾病。 本发明使用具有序列表中SEQ ID NO：1,3,26或27所示氨基酸序列的蛋白质或其中一个或多个酸被取代或缺失的所述氨基酸序列的变体，或一个或多个 酸被插入或添加并且具有通过β1-4键和编码所述蛋白质的核酸将N-乙酰半乳糖胺（GalNAc）转移到用作底物的N-乙酰葡糖胺的活性。