摘要:
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.
摘要:
A loudspeaker module includes a hollow main body, two rotatable connecting portions, and two loudspeakers. The hollow main body includes two opposite sidewalls. Each of the opposite sidewall defines a first opening, an inner sidewall of the first opening defines an annular rotating slot. One end of the connecting portion extends an annular flange shaped corresponding to the rotating slot. The two rotatable connecting portions are respectively rotatably connected to the main body via the flange rotating about the rotating slot. Two loudspeakers are disposed in an end of the corresponding rotatable connecting portion away from the main body.
摘要:
A pilot and channel estimation method for SDMA MIMO transmission downlink is provided in the present invention, and the method provides possibility for saving the orthogonal pilot resources; the pilot signals of different users in the transmitting antenna domain can occupy the same time-frequency resources, and thereby the pilot overhead of system resources can be reduced greatly; the method includes: for the MIMO transmission downlink that employs pre-coding for SDMA, taking the quantity of orthogonal pilot resources occupied by the users in the pre-coding domain as the number of data streams that can be transmitted or the number of spatial dimensions occupied first, at the transmitting end of the base station; then, performing SDMA transmission pre-coding for the orthogonal pilots in the pre-coding domain in the same way as the data signals, to obtain the pilot signals of the users in the transmitting antenna domain; wherein, the pilots of the users in the pre-coding domain can be orthogonal in the frequency domain or code domain, and the pilots of different users in the pre-coding domain can be identical or not identical to each other; the pilot signals of different users in the transmitting antenna domain can occupy the same time-frequency resources.
摘要:
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; -A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B1 and B2 rings are pyridyl rings, wherein the B1 and B2 rings are each fused to the A ring and the B1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R1, R2, and R4, and the B2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R3, R7, and R3 71, J2, and J3 are at each occurrence the same or different and are independently -AIQA2-; Q is a bond, O, S, S(0), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3 alkylene, substituted C1-3 alkylene, C24 alkenylene, and substituted C24 alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein.
摘要:
The present invention provides a semiconductor laser package including a heat sink, a laser bar with a plurality of lasers on the heat sink, an insulated layer arranged between said heat sink and said laser bar, a solder layer combining said insulated layer with said laser bar, and a clearance crossing said solder layer defined between adjacent lasers.
摘要:
The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译:本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式,其中A,B,L,R 1,R 2, R 4,R 4,R 5,n,W,U,X,Y,Z,U a, 在本说明书中定义,其可用作TNF-α转化酶(TACE)和/或 基质金属蛋白酶(MMP)抑制剂。
摘要:
Based on information associated with users, a social networking system recommends one or more groups for a target user to join or to create. Characteristics of the target user, characteristics of users connected to the target user, characteristics of candidate groups in the social networking system may be used to identify groups for recommendation. The social networking system may provide questions to the target user and recommend a group to the target user based on received answers to the questions. For example, the answers to the provided question identify one or more characteristics of the target user, which are used to select a group for recommendation. Additionally, the social networking system may recommend additional users for the target user to add or invite to a group based on characteristics of the target user, the additional users, and/or the group.
摘要:
Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.