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公开(公告)号：US12060601B2
公开(公告)日：2024-08-13
申请号：US16775034
申请日：2020-01-28
Applicant: InnovaPrep LLC
Inventor： David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
CPC classification number: C12Q1/24 , C12Q1/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.
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公开(公告)号：US12055469B2
公开(公告)日：2024-08-06
申请号：US18205494
申请日：2023-06-02
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/0032 , B01D46/543 , B01D46/70 , G01N1/2205 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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公开(公告)号：US11986168B2
公开(公告)日：2024-05-21
申请号：US17103912
申请日：2020-11-24
Applicant: InnovaPrep LLC
Inventor： Alec D. Adolphson , Ann K. Packingham , Andrew E. Page , David S. Alburty , Zachary A. Packingham , John D. Birkenholz , Michael F. Fischer
CPC classification number: A61B10/02 , A61B10/0096 , A61B2010/0216 , B01L3/5029 , G01N2001/028
Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.
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公开(公告)号：US20230358643A1
公开(公告)日：2023-11-09
申请号：US18222471
申请日：2023-07-16
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
CPC classification number: G01N1/10 , G01N1/34 , G01N1/4077 , G01N1/14 , G01N2001/4088
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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公开(公告)号：US20230304906A1
公开(公告)日：2023-09-28
申请号：US18205494
申请日：2023-06-02
Applicant: INNOVAPREP LLC
Inventor： Andrew Edward Page , David Scott Alburty , Alec D. Adolphson , Pamela S. Murowchick , Zachary A. Packingham
CPC classification number: G01N1/4077 , B01D46/70 , G01N1/2205 , B01D46/0032 , B01D46/543 , G01N2001/4088
Abstract: Devices, systems and methods are disclosed which relate to using a wet foam elution method for removal of particles from a flat filter. Particles are captured from the atmosphere onto the flat filter. The flat filter is then placed into an extractor which passes a stream of wet foam through the flat filter. Expansion of the foam works to efficiently remove captured particles. The foam flows from the filter along with the captured particles into a sample container. Once in the sample container, the foam quickly breaks down leaving an analysis ready liquid sample.
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Patent Agency Ranking
公开(公告)号：US20210308664A1
公开(公告)日：2021-10-07
申请号：US17222951
申请日：2021-04-05
Applicant: INNOVAPREP LLC
Inventor： John D. Birkenholz , Andrew Edward Page , Zachary A. Packingham , David S. Alburty , Alec D. Adolphson , Steven Dale Graham , Michael F. Fischer
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect and identify. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.
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公开(公告)号：US20210215583A1
公开(公告)日：2021-07-15
申请号：US17194169
申请日：2021-03-05
Applicant: INNOVAPREP LLC
Inventor： Andew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
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公开(公告)号：US10942097B2
公开(公告)日：2021-03-09
申请号：US15456981
申请日：2017-03-13
Applicant: InnovaPrep LLC
Inventor： Andrew Edward Page , Zachary A. Packingham , David Scott Alburty , Alec D. Adolphson
Abstract: Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.
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公开(公告)号：US20200224242A1
公开(公告)日：2020-07-16
申请号：US16775034
申请日：2020-01-28
Applicant: InnovaPrep LLC
Inventor： David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.
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公开(公告)号：US09738918B2
公开(公告)日：2017-08-22
申请号：US14313618
申请日：2014-06-24
Applicant: InnovaPrep LLC
Inventor： David S. Alburty , Andrew E. Page , Zachary A. Packingham , Daniel B. Marske
CPC classification number: C12Q1/24 , C12Q1/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
Abstract: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. Additional concentration stages may be added in “cascade” fashion, in order to concentrate particles below the size cut of each preceding stage remaining in the separated fluid in a concentrated sample suspension. This process can also be used to create a “band-pass” concentration for concentration of a particular target size particle within a narrow range.
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