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公开(公告)号：US20160338356A1
公开(公告)日：2016-11-24
申请号：US14715690
申请日：2015-05-19
发明人： Willy Chin , James L. Hedrick , Nor Lizawati Ibrahim , Ashlynn L. Z. Lee , Robert J. Ono , Qingxing Xu , Yi Yan Yang
CPC分类号： A01N47/44 , C08G18/3819 , C08G18/3831 , C08G18/4833 , C08G18/6681 , C08G18/73 , C08G18/755 , C08G64/0241 , C08G64/42 , A01N25/10
摘要： Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
摘要翻译： 已经制备了抗微生物阳离子聚碳酸酯和聚氨酯，其包含一种或多种侧链胍和/或异硫脲基。 另外，制备具有与包含胍和/或异硫脲基团的表面基团连接的二氧化硅核心的抗微生物颗粒。 阳离子聚合物和阳离子颗粒可以是抗革兰阴性微生物，革兰氏阳性微生物和/或真菌的有效抗微生物剂。
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公开(公告)号：US09469726B2
公开(公告)日：2016-10-18
申请号：US14506733
申请日：2014-10-06
发明人： Daniel J. Coady , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Yi Yan Yang
CPC分类号： C08G64/18 , A61K9/0019 , A61K9/146 , A61K45/06 , C08G64/0233 , C08G64/0241 , C08G64/30 , C08G64/42
摘要： Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.
摘要翻译： 通过有机酸催化的开环聚合（ROP）制备具有活性酯侧链的环状碳酸酯单体的水溶性可生物降解聚合物。 包含活性酯侧链的初始聚合物用氨基醇处理，氨基醇将活性酯基转变成带有单羟基烷基和/或二羟基烷基的N-取代酰胺基，从而形成水溶性聚合物。 水溶性聚合物是无毒的，并且在缓冲的血清溶液中表现出隐形性质。
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23.发明申请VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS 有权维生素功能化凝胶形成用于生物医学应用的嵌段共聚物公开(公告)号：US20150231257A1
公开(公告)日：2015-08-20
申请号：US14697878
申请日：2015-04-28
IPC分类号： A61K47/34 , C08G65/331 , A61K31/65 , A61K31/765 , A61K31/4196
CPC分类号： C08G64/183 , A61K9/0024 , A61K9/06 , A61K31/355 , A61K31/592 , A61K31/593 , A61K47/34 , A61K47/551 , A61K47/60 , A61K2039/505 , A61K2039/54 , A61P35/00 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C08G65/3318 , C08G2210/00 , Y02A50/473
摘要： Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
摘要翻译： 制备凝胶形成嵌段共聚物，其包括：i）主要由二价聚（环氧乙烷）链和ii）两个周边单碳酸酯或聚碳酸酯疏水嵌段组成的中心亲水嵌段。 疏水性嵌段包含一种或多种含有维生素的亚基。 含维生素的亚基包含碳酸酯主链部分和包含共价结合形式的维生素的侧链。 凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。 水凝胶组合物可适用于贮存注射。 用包含抗微生物阳离子聚合物和抗微生物化合物的组合物观察到对微生物的毒性的协同增强。
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24.发明授权Catalyst-free methods of forming polyurethanes from pentafluorophenyl carbonates 有权从五氟苯基碳酸酯形成聚氨酯的无催化剂方法公开(公告)号：US09062160B1
公开(公告)日：2015-06-23
申请号：US14162222
申请日：2014-01-23
申请人： International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
发明人： Julian M. W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , James L. Hedrick , Zhan Yuin Ong , Haritz Sardon , Yi Yan Yang
CPC分类号： C08G71/04 , C08G65/007 , C08G73/02 , C08G73/0206
摘要： One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.
摘要翻译： 形成聚氨酯的一种无催化剂的方法包括形成包含第一单体，表面活性剂，与水不混溶的有机溶剂和水的第一乳液。 第一单体包含两个或多个五氟苯基碳酸酯基团。 将第一乳液与含有包含两个或多个亲核胺基团的第二单体的含水混合物组合，从而形成第二乳液。 通过界面聚合使第二乳液的第一和第二单体反应，由此形成聚氨酯。 聚氨酯的数均分子量（Mn）可以为约30000至约80000.该方法与通过环状碳酸酯前体向第一单体引入侧链官能团相容。
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25.发明授权Vitamin functionalized gel-forming block copolymers for biomedical applications 有权用于生物医学应用的维生素官能化凝胶形成嵌段共聚物公开(公告)号：US09040034B2
公开(公告)日：2015-05-26
申请号：US13859062
申请日：2013-04-09
CPC分类号： C08G64/183 , A61K9/0024 , A61K9/06 , A61K31/355 , A61K31/592 , A61K31/593 , A61K47/34 , A61K47/551 , A61K47/60 , A61K2039/505 , A61K2039/54 , A61P35/00 , C07K16/32 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C08G65/3318 , C08G2210/00 , Y02A50/473
摘要： Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
摘要翻译： 制备凝胶形成嵌段共聚物，其包括：i）主要由二价聚（环氧乙烷）链和ii）两个周边单碳酸酯或聚碳酸酯疏水嵌段组成的中心亲水嵌段。 疏水性嵌段包含一种或多种含有维生素的亚基。 含维生素的亚基包含碳酸酯主链部分和包含共价结合形式的维生素的侧链。 凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。 水凝胶组合物可适用于贮存注射。 用包含抗微生物阳离子聚合物和抗微生物化合物的组合物观察到对微生物的毒性的协同增强。
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26.发明申请CATIONIC POLYMERS FOR ANTIMICROBIAL APPLICATIONS AND DELIVERY OF BIOACTIVE MATERIALS 有权用于抗生素应用和递送生物材料的阳离子聚合物公开(公告)号：US20140220093A1
公开(公告)日：2014-08-07
申请号：US14246045
申请日：2014-04-05
发明人： Daniel J. Coady , Amanda C. Engler , Kazuki Fukushima , James L. Hedrick , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A01N37/44
CPC分类号： A01N37/44 , A01N33/12 , A61K48/0041 , C08G83/004 , C12N15/88 , A01N25/10 , A01N2300/00
摘要： A cationic star polymer is disclosed of the general formula (1): wherein w′ is a positive number greater than or equal to 3, I′ is a dendritic polyester core covalently linked to w′ independent peripheral linear cationic polymer chains P′. Each of the chains P′ comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.
摘要翻译： 公开了通式（1）的阳离子星形聚合物：其中w'是大于或等于3的正数，I'是与w'独立的外部线性阳离子聚合物链P'共价连接的树枝状聚酯芯。 每个链P'包含阳离子重复单元，其包含i）选自脂族碳酸酯，脂族酯，脂族氨基甲酸酯，脂族脲，脂族硫代氨基甲酸酯，脂族二硫代碳酸酯及其组合的骨架官能团，和ii） 侧链包含季胺基。 季胺基包括与i）正电荷氮和ii）芳环直接共价连接的二价亚甲基。
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公开(公告)号：US11930818B2
公开(公告)日：2024-03-19
申请号：US16738517
申请日：2020-01-09
发明人： Victoria A. Piunova , Noah Frederick Fine Nathel , James L. Hedrick , Yi Yan Yang , Willy Chin , Zhi Xiang Voo
IPC分类号： A01N47/06 , A01N25/00 , C08G64/02 , C08G64/16 , C08G64/42 , C09D5/14 , C09D169/00 , C08G83/00
CPC分类号： A01N47/06 , A01N25/00 , C08G64/0241 , C08G64/1641 , C08G64/1658 , C08G64/42 , C09D5/14 , C09D169/00 , C08G83/004 , A01N25/00 , A01N43/90 , A01N59/00
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US20220009966A1
公开(公告)日：2022-01-13
申请号：US17487225
申请日：2021-09-28
发明人： Payel Das , Flaviu Cipcigan , James L. Hedrick , Yi Yan Yang , Kahini Wadhawan , Inkit Padhi , Enara C Vijil , Pang Kern Jeremy Tan
IPC分类号： C07K7/08
摘要： De novo, artificial intelligence (AI) designed antimicrobial peptides (AMPs), antibacterial products comprising the AMPs and methods for treating bacterial infections using the products are provided. In one or more embodiments, the AMPs were designed using conditional latent attribute space sampling (CLaSS). The AMPs comprise up to twenty natural amino acids in length, including one with twelve and another with thirteen natural amino acids in length. The AMPs demonstrate low-toxicity and show high antimicrobial potency against diverse pathogens including multi-medication-resistant Gram negative Klebsiella pneumoniae.
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29.发明授权公开(公告)号：US11167036B2
公开(公告)日：2021-11-09
申请号：US16201155
申请日：2018-11-27
IPC分类号： A61K47/59 , A61K31/4188 , A61K31/155 , A61K47/55
摘要： The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
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公开(公告)号：US11006628B2
公开(公告)日：2021-05-18
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N37/26 , A01N43/50 , A01N47/44 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , C08L101/00 , A61Q17/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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