-
公开(公告)号：US07655761B2
公开(公告)日：2010-02-02
申请号：US11952802
申请日：2007-12-07
IPC分类号： C07K16/00
CPC分类号： C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要： CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 来自哺乳动物的CTLA-8相关抗原，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述抗原的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
-
公开(公告)号：US07625720B2
公开(公告)日：2009-12-01
申请号：US11604559
申请日：2006-11-27
CPC分类号： C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要： CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 来自哺乳动物的CTLA-8相关抗原，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述抗原的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
-
公开(公告)号：US07005501B2
公开(公告)日：2006-02-28
申请号：US10366791
申请日：2003-02-14
CPC分类号： C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要： CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.
-
公开(公告)号：US06562578B1
公开(公告)日：2003-05-13
申请号：US09480297
申请日：2000-01-10
IPC分类号： G01N3353
CPC分类号： C07K14/52 , A61K38/00 , C07K14/54 , G01N33/6869
摘要： IL-17-like cytokines from mammals, reagents and diagnostic kits related thereto including purified proteins, specific antibodies, and nucleic acids are provided. Methods of using the reagents and diagnostic kits are also provided.
摘要翻译： 提供了来自哺乳动物的IL-17样细胞因子，与其相关的试剂和诊断试剂盒，包括纯化的蛋白质，特异性抗体和核酸。 还提供了使用试剂和诊断试剂盒的方法。
-
25.发明申请公开(公告)号：US20090274695A1
公开(公告)日：2009-11-05
申请号：US12290013
申请日：2008-10-23
申请人： J. Fernando Bazan , Peter Kirk
发明人： J. Fernando Bazan , Peter Kirk
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , A61P35/04 , A61P19/02 , A61P27/02 , G01N33/566
CPC分类号： C07K16/24 , A61K38/19 , A61K2039/505
摘要： The invention concerns methods for inhibiting the binding of urokinase-type plasminogen activator (uPA) to its receptor uPAR and/or inhibiting uPA biological activity. The invention further concerns methods for inhibiting tumor formation or metastasis, angiogenesis, such as tumor angiogenesis, and screening assays for identifying CYTL1 agonists.
摘要翻译： 本发明涉及抑制尿激酶型纤溶酶原激活物（uPA）与其受体uPAR结合和/或抑制uPA生物活性的方法。 本发明进一步涉及抑制肿瘤形成或转移，血管生成（例如肿瘤血管生成）和用于鉴定CYTL1激动剂的筛选测定法的方法。
-
公开(公告)号：US20080199477A1
公开(公告)日：2008-08-21
申请号：US12100088
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
IPC分类号： A61K39/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
-
公开(公告)号：US20080194800A1
公开(公告)日：2008-08-14
申请号：US12100108
申请日：2008-04-09
申请人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
发明人： Gerard T. Hardiman , Fernando L. Rock , J. Fernando Bazan , Robert A. Kastelein , Stephen W.K. Ho , Yong-Jun Liu
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding mammalian Toll-like receptors (TLRs) have been identified in human cells. Recombinantly produced TLRs are used in the preparation of antibodies that are capable of binding to the TLRs. The antibodies are advantageously used in the prevention and treatment of septic shock, inflammatory conditions, and viral infections.
摘要翻译： 已经在人细胞中鉴定了编码哺乳动物Toll样受体（TLR）的核酸。 重组产生的TLR用于制备能够结合TLR的抗体。 抗体有利地用于预防和治疗败血性休克，炎性病症和病毒感染。
-
公开(公告)号：US07205381B2
公开(公告)日：2007-04-17
申请号：US09770528
申请日：2001-01-25
IPC分类号： C07K16/00
CPC分类号： C07K14/54 , A61K38/00 , C07K14/545 , C07K2319/00
摘要： Nucleic acids encoding mammalian, e.g., rodent, IL-1δ, IL-1ε, purified IL-1δ and IL-1ε proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
摘要翻译： 编码哺乳动物的核酸，例如啮齿类动物，IL-1delta，IL-1β，纯化的IL-1d和IL-1蛋白及其片段。 还提供了抗体，包括多克隆和单克隆抗体。 提供了用于诊断和治疗用途的组合物的方法。
-
公开(公告)号：US5985828A
公开(公告)日：1999-11-16
申请号：US472097
申请日：1995-06-07
申请人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
发明人： Kevin W. Moore , Ying Liu , Alice Suk-Yue Ho , Di-Hwei Hsu , J. Fernando Bazan , Jimmy C. Tan , Chuan-Chu Chou
IPC分类号： G01N33/577 , A61K38/00 , A61K39/395 , A61P31/04 , A61P37/00 , C07H21/04 , C07K14/54 , C07K14/715 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , A61K38/16
CPC分类号： C07K14/7155 , C07K14/5428 , A61K38/00 , C07K2319/00
摘要： Receptor components for IL-10 are isolated and characterized. The amino acid sequence and nucleic acid encoding various species variants of the receptors are disclosed. Uses of the purified receptor gene and polypeptide are disclosed, including means for screening for agonists and antagonists of the receptor ligands, for producing diagnostic or therapeutic reagents, and for producing antibodies. Therapeutic or diagnostic reagents and kits are also provided.
摘要翻译： 分离和表征IL-10的受体组分。 公开了编码受体的各种变体的氨基酸序列和核酸。 公开了纯化的受体基因和多肽的用途，包括用于筛选受体配体的激动剂和拮抗剂，用于产生诊断或治疗试剂以及产生抗体的手段。 还提供治疗或诊断试剂和试剂盒。
-
公开(公告)号：US08492528B2
公开(公告)日：2013-07-23
申请号：US13434629
申请日：2012-03-29
申请人： J. Fernando Bazan
发明人： J. Fernando Bazan
CPC分类号： C07K14/54 , A61K38/00 , A61K2039/505 , C07H21/04 , Y10T436/143333
摘要： Purified genes encoding interleukin-B30 from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的白细胞介素-B30的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
-
-
-
-
-
-
-
-
-
搜索结果
61 条记录 (耗时 0.053 秒)
