公开(公告)号：US5424731A

公开(公告)日：1995-06-13

申请号：US720128

申请日：1991-06-24

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: H03M11/22 ,  H03M11/00

CPC classification number: H03M11/22

Abstract: A device for detecting switch closure such as in a keypad for entering data comprising a matrix of conductor pairs and switches, each pair of conductors shorted by the pressing of a particular switch, and current-regulating devices on each conductor for limiting current in one direction and passing it without limit in the other direction. The device is driven by alternating current. The ends of the conductors in a conductor pair limit current of opposing polarities with respect to each other so that the signal on a shorted pair is an alternating current signal with a unique combination of a positive and a negative peak, which, when analyzed, allows the determination of which key was pressed. The binary identification of the pressed key is passed to the input port of a host device.

Abstract translation: 一种用于检测开关闭合的装置，例如用于输入包括导体对和开关的矩阵的数据的键盘，每对导体通过按压特定开关而短路，以及每个导体上的电流调节装置，用于限制一个方向上的电流 并在另一个方向无限制地通过。 该器件由交流电驱动。 导体对中的导体的端部相对于彼此限制相对极性的电流，使得短路对上的信号是具有正峰值和负峰值的唯一组合的交流信号，其在分析时允许 确定哪个关键字被压制。 按下的键的二进制识别被传递到主机设备的输入端口。

公开(公告)号：US5217009A

公开(公告)日：1993-06-08

申请号：US727705

申请日：1991-07-10

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: A61N1/36

CPC classification number: A61N1/326 ,  A61N1/36014

Abstract: An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Abstract translation: 一种用于刺激骨组织用于刺激骨生长或通过直接施用于患者皮肤来治疗骨质疏松症的装置，该交流电信号包括已知模拟骨中压电组分的波形。 根据需要，该装置可以通过移动开关刺激骨生长或治疗骨质疏松症。 基于低功耗CMOS技术，封装在防潮外壳中，可以舒适地安装，两个不稳定的多谐振荡器产生所需的波形。 波形的幅度，脉冲宽度和脉冲频率以及子脉冲宽度和子脉冲频率都是可调的。 优选由标准9伏电池供电的装置包括信号幅度传感器，并且警告信号指示正在产生输出并且需要更换电池。

公开(公告)号：US5157465A

公开(公告)日：1992-10-20

申请号：US596130

申请日：1990-10-11

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: G01J3/02 ,  G01J3/14 ,  G01J3/46 ,  G01J3/50 ,  G01J3/51 ,  G02B6/04

CPC classification number: G02B6/04 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0221 ,  G01J3/46 ,  G01J3/465 ,  G01J3/50 ,  G01J3/502 ,  G01J2003/467 ,  G01J3/14 ,  G01J3/513

Abstract: Apparatus for color measurements according to the C.I.E. system comprises a first fiber optic cable for receiving and linearizing light from a light source, a lens system for spectrally displaying the linearized light and focusing the light on one end of a trifurcated fiber optic assembly that integrates and separates the light according to the three C.I.E. tristimulus functions. The separated light is received by three photodiodes and electronically evaluated to determine the magnitude of the light corresponding to the tristimulus functions. The fiber optic assembly is made by forming, at one end, a bundle of optic fibers to match the contours of one of the tristimulus functions, encapsulating that bundle, adding a second bundle that, together with the first bundle, will match the contours of the first plus one other tristimulus function, encapsulating that second bundle, then adding a third bundle which together with the first and second bundles, has contours matching the sum of all three tristimulus functions. At the other end of the assembly the three bundles are separated and aligned with their respective photodiodes.

Abstract translation: 根据C.I.E.的颜色测量装置 系统包括用于接收和线性化来自光源的光的第一光纤电缆，用于光谱显示线性化光并将光聚焦在根据三个C.I.E.E.E.集成和分离光的三叉光纤组件的一端上的透镜系统。 三刺激功能。 分离的光被三个光电二极管接收，并进行电子评估，以确定对应于三刺激函数的光的大小。 光纤组件通过在一端形成一束光纤以匹配三刺激函数之一的轮廓来制造，封装该束，添加第二束，其与第一束一起匹配 第一加一其他三刺激函数，封装该第二束，然后添加第三束与第一束和第二束一起具有匹配所有三个三刺激函数之和的轮廓。 在组件的另一端，三个束分离并与它们各自的光电二极管对准。

公开(公告)号：US5119014A

公开(公告)日：1992-06-02

申请号：US664915

申请日：1991-03-05

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: G05F1/577 ,  H02H9/00

CPC classification number: H02H9/001 ,  G05F1/577 ,  Y10S323/901 ,  Y10T307/484

Abstract: A sequential power-up circuit for starting several electrical load elements in series to avoid excessive current surge, comprising a voltage ramp generator and a set of voltage comparators, each comparator having a different reference voltage and interfacing with a switch that is capable of turning on one of the load elements. As the voltage rises, it passes the reference voltages one at a time and causes the switch corresponding to that voltage to turn on its load element. The ramp is turned on and off by a single switch or by a logic-level electrical signal. The ramp rate for turning on the load element is relatively slow and the rate for turning the elements off is relatively fast. Optionally, the duration of each interval of time between the turning on of the load elements is programmable.

Abstract translation: 一种顺序上电电路，用于串联启动多个电负载元件以避免过度的电流浪涌，包括电压斜坡发生器和一组电压比较器，每个比较器具有不同的参考电压并与能够接通的开关相连接 其中一个负载元素。 随着电压上升，它一次通过参考电压，并使与该电压相对应的开关导通其负载元件。 斜坡通过单个开关或逻辑电平电信号打开和​​关闭。 开启负载元件的斜坡速率相对较慢，关闭元件的速率相对较快。 可选地，负载元件的接通之间的每个时间间隔的持续时间是可编程的。

公开(公告)号：US5054023A

公开(公告)日：1991-10-01

申请号：US350953

申请日：1989-05-12

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: G06F11/00

CPC classification number: G06F11/0757

Abstract: A method and apparatus for monitoring a process having a periodic output so that the process equipment is not damaged in the event of a controller failure, comprising a low-pass and peak clipping filter, an event detector that generates an event pulse for each valid change in magnitude of the filtered periodic output, a timing pulse generator, a counter that increments upon receipt of any timing pulse and resets to zero on receipt of any event pulse, an alarm that alerts when the count reaches some preselected total count, and a set of relays that opens to stop power to process equipment. An interface module can be added to allow the switch to accept a variety of periodic output signals.

Abstract translation: 一种用于监测具有周期性输出的处理的方法和装置，使得在控制器故障的情况下处理设备不被损坏，包括低通和峰值截止滤波器，事件检测器，其为每个有效变化生成事件脉冲 在过滤的周期性输出的幅度上，定时脉冲发生器，计数器，其在接收到任何定时脉冲时增加，并且在接收到任何事件脉冲时复位为零，当计数达到某些预选总计数时警报的警报，以及一组 的继电器，停止处理设备的电力。 可以添加一个接口模块，以允许开关接受各种周期性的输出信号。

公开(公告)号：US5030011A

公开(公告)日：1991-07-09

申请号：US465842

申请日：1990-01-16

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: B01F7/00 ,  B01F15/00

CPC classification number: B01F7/00175

Abstract: A blade system for stirring and agitating a medium, comprising a shaft bearing a plurality of paddles, each having a different geometry and each having approximately the same rotational moment. The geometrically different paddles sweep through different volumes of the medium to minimize shear zone development and maximize the strength of the system with respect to medium-induced stress.

Abstract translation: 一种用于搅拌和搅拌介质的叶片系统，包括具有多个叶片的轴，每个叶片具有不同的几何形状并且每个具有大致相同的旋转力矩。 几何不同的桨叶扫过介质的不同体积，以最小化剪切带的发展，并最大限度地提高系统相对于介质诱导应力的强度。

公开(公告)号：US4952892A

公开(公告)日：1990-08-28

申请号：US350817

申请日：1989-05-12

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: H01P5/02 ,  H01Q13/06

CPC classification number: H01Q13/06 ,  H01P5/024

Abstract: A technique for modifying the end portion of a wave guide, whether hollow or solid, carrying electromagnetic, acoustic or optical energy, to produce a gradual impedance change over the length of the end portion, comprising the cutting of longitudinal, V-shaped grooves that increase in width and depth from beginning of the end portion of the wave guide to the end of the guide so that, at the end of the guide, no guide material remains and no surfaces of the guide as modified are perpendicular to the direction of energy flow. For hollow guides, the grooves are cut beginning on the interior surface; for solid guides, the grooves are cut beginning on the exterior surface. One or more resistive, partially conductive or nonconductive sleeves can be placed over the exterior of the guide and through which the grooves are cut to smooth the transition to free space.

Abstract translation: 一种技术，用于修改波导的端部，无论是中空的还是实心的，承载电磁，声或光能，以在端部的长度上产生逐渐的阻抗变化，包括切割纵向的V形槽， 从波导的端部开始到引导件的端部的宽度和深度增加，使得在引导件的端部处不留下引导材料，并且未被修改的引导件的表面垂直于能量的方向 流。 对于空心导轨，槽从内表面开始切割; 对于固体导向器，凹槽从外表面开始切割。 一个或多个电阻的，部分导电的或非导电的套筒可以放置在引导件的外部上，并且通过该套筒切割凹槽以平滑过渡到自由空间。

公开(公告)号：US08785196B2

公开(公告)日：2014-07-22

申请号：US12904873

申请日：2010-10-14

Applicant: James W. Kronberg ,  Timothy Ganey ,  Stephen L. Gordon

Inventor： James W. Kronberg ,  Timothy Ganey ,  Stephen L. Gordon

IPC: C12N5/00 ,  C12N5/02

CPC classification number: C12M35/02 ,  A61N1/326 ,  A61N1/40 ,  C12M21/08

Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells. The methods and devices described are useful in promoting repair of bone fractures, cartilage and connective tissue repair as well as for engineering tissue for transplantation.

Abstract translation: 提供组合物和方法用于调节骨，软骨或其它结缔组织的生长，发育和修复。 提供装置和刺激波形以差异调节成骨细胞，软骨细胞和其他结缔组织细胞的行为，以促进体外或体内应用的增殖，分化，基质形成或矿化。 可以使用具有电荷平衡信号的单元的连续模式和脉冲突发模式刺激。 骨骼，软骨和其他结缔组织生长部分由一氧化氮通过电刺激释放而被刺激，并且可以通过共同给予NO供体和NO合酶抑制剂来调节。 骨骼，软骨和其他结缔组织生长部分通过释放BMP-2和BMP-7而受到刺激，以响应电刺激以促进细胞分化。 描述的方法和装置可用于促进骨折，软骨和结缔组织修复以及用于移植的工程组织的修复。

公开(公告)号：US08159312B2

公开(公告)日：2012-04-17

申请号：US11769176

申请日：2007-06-27

Applicant: James W. Kronberg

Inventor： James W. Kronberg

IPC: H03H7/00 ,  H01G9/155 ,  H03H1/02

CPC classification number: A61N1/32 ,  A61N1/40 ,  H01G9/155 ,  H01G11/08 ,  H01G11/82 ,  H04B3/56 ,  H04B5/0012 ,  H04B2203/5483 ,  Y02E60/13

Abstract: A method and class of circuit configurations for coupling low-frequency signals from one stage of an electronic apparatus to another stage, from the outside world to such a stage, or from such a stage to the outside world, through the use of a plurality of symmetrical double-layer capacitors combined with other electronic components are disclosed. The capacitors are used for signal transmission while blocking direct current, rather than for energy storage. Use of double-layer capacitors in place of more conventional capacitors permits the transmission of a much wider range of signals with far less distortion. The technology is particularly well-adapted to use in medical devices, including bioelectronic stimulators, where redundant devices are required for safety in case of single component failure while unacceptable levels of distortion may occur when conventional components are used.

Abstract translation: 一种用于将低频信号从电子设备耦合到另一个阶段的电路配置的方法和类别，从外部世界到这样一个阶段，或者从这样的阶段到外部世界，通过使用多个 公开了与其他电子部件组合的对称双层电容器。 电容器用于信号传输，同时阻止直流电而不是用于储能。 使用双层电容器代替更传统的电容器允许传输更宽范围的信号，具有更少的失真。 该技术特别适用于包括生物电子刺激器在内的医疗设备，其中在单一部件故障的情况下需要冗余设备来实现安全，而在使用常规部件时可能会发生不可接受的失真水平。

公开(公告)号：US20110217775A1

公开(公告)日：2011-09-08

申请号：US12904873

申请日：2010-10-14

Applicant: James W. Kronberg ,  Timothy Ganey ,  Stephen L. Gordon

Inventor： James W. Kronberg ,  Timothy Ganey ,  Stephen L. Gordon

IPC: C12N5/071 ,  C12M3/00 ,  B32B15/04 ,  C25D7/00

CPC classification number: C12M35/02 ,  A61N1/326 ,  A61N1/40 ,  C12M21/08

Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells. The methods and devices described are useful in promoting repair of bone fractures, cartilage and connective tissue repair as well as for engineering tissue for transplantation.

Abstract translation: 提供组合物和方法用于调节骨，软骨或其它结缔组织的生长，发育和修复。 提供装置和刺激波形以差异调节成骨细胞，软骨细胞和其他结缔组织细胞的行为，以促进体外或体内应用的增殖，分化，基质形成或矿化。 可以使用具有电荷平衡信号的单元的连续模式和脉冲突发模式刺激。 骨骼，软骨和其他结缔组织生长部分由一氧化氮通过电刺激释放而被刺激，并且可以通过共同给予NO供体和NO合酶抑制剂来调节。 骨骼，软骨和其他结缔组织生长部分通过释放BMP-2和BMP-7而受到刺激，以响应电刺激以促进细胞分化。 描述的方法和装置可用于促进骨折，软骨和结缔组织修复以及用于移植的工程组织的修复。