利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

36 条记录 (耗时 0.025 秒)

    Nucleic acids encoding neural axon outgrowth modulators
    22.
    发明授权
    Nucleic acids encoding neural axon outgrowth modulators 失效
    核酸编码神经轴突生长调节剂

    公开(公告)号：US5565331A

    公开(公告)日：1996-10-15

    申请号：US152019

    申请日：1993-11-12

    申请人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

    发明人： Marc Tessier-Lavigne ,  Tito Serafini ,  Timothy Kennedy ,  Merysia Placzek ,  Thomas Jessell ,  Jane Dodd

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61P25/00 ,  C07K14/47 ,  C07K14/475 ,  C07K14/48 ,  C07K14/705 ,  C07K14/71 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  G01N33/53 ,  G01N33/68 ,  C12N15/00

    CPC分类号： G01N33/6896 ,  C07K14/4705 ,  C07K14/475 ,  C07K14/705 ,  C07K14/71 ,  A61K38/00 ,  G01N2500/04

    摘要： A novel classes of neural axon outgrowth promoting and orienting proteins, nucleic acids encoding such proteins and receptors which selectively bind such proteins are disclosed. The disclosed neural axon outgrowth promoting and orienting proteins include the laminin-related p75/p78 family; a family of vertebrate proteins which promote axon outgrowth and/or orientation, and p75/p78 family-specific receptors, including receptors found on spinal nerve axons, especially growth cones. Also disclosed are agents including peptides derived from the disclosed neural axon outgrowth promoting proteins capable of effecting axon outgrowth, orientation and regeneration. These agents provide small molecular weight modulators of nerve cell growth useful in the treatment of neurological disease and injury. The disclosed compositions also find use variously in screening chemical libraries for regulators of axon outgrowth and orientation, in genetic mapping, as probes for related genes, as diagnostic reagents for genetic neurological disease and in the production of specific cellular and animal systems for the development of neurological disease therapy.

    摘要翻译： 公开了一类促进和定向蛋白质的神经轴突生长，编码这种蛋白质的核酸和选择性结合这些蛋白质的受体。 所公开的神经轴突生长促进和定向蛋白质包括层粘连蛋白相关的p75 / p78家族; 促进轴突生长和/或取向的脊椎动物蛋白家族，以及p75 / p78家族特异性受体，包括在脊髓神经轴突，特别是生长锥上发现的受体。 还公开了包括衍生自所公开的神经轴突生长促进能够产生轴突向外生长，取向和再生的蛋白质的肽的试剂。 这些试剂提供了可用于治疗神经疾病和损伤的神经细胞生长的小分子量调节剂。 所公开的组合物还可用于筛选用于轴突生长和取向的调节剂的化学文库，遗传作图中作为相关基因的探针，作为遗传神经疾病的诊断试剂，以及用于开发特异性细胞和动物系统的生产 神经疾病治疗。

    Modulating robo: ligand interactions
    23.
    发明申请
    Modulating robo: ligand interactions 审中-公开
    调节robo：配体相互作用

    公开(公告)号：US20090155928A1

    公开(公告)日：2009-06-18

    申请号：US11891963

    申请日：2007-08-13

    申请人： Corey S. Goodman ,  Thomas Kidd ,  Katja Brose ,  Marc Tessier-Lavigne

    发明人： Corey S. Goodman ,  Thomas Kidd ,  Katja Brose ,  Marc Tessier-Lavigne

    IPC分类号： G01N33/566 ,  C07K14/00 ,  C12N15/11

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/4702 ,  G01N33/566 ,  G01N33/68 ,  G01N2333/43573 ,  G01N2500/02

    摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.

    摘要翻译： 公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。 用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。 这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用 的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述琼脂调节所述Robo和Slit多肽的相互作用。 调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。 在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

    Modulating Robo: ligand interactions
    26.
    发明授权
    Modulating Robo: ligand interactions 失效
    调制Robo：配体相互作用

    公开(公告)号：US06861228B2

    公开(公告)日：2005-03-01

    申请号：US10289776

    申请日：2002-11-06

    申请人： Corey S. Goodman ,  Thomas Kidd ,  Katja Brose ,  Marc Tessier-Lavigne

    发明人： Corey S. Goodman ,  Thomas Kidd ,  Katja Brose ,  Marc Tessier-Lavigne

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61P43/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N15/12 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  G01N33/68 ,  G01N33/53 ,  A61K39/395

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/4702 ,  G01N33/566 ,  G01N33/68 ,  G01N2333/43573 ,  G01N2500/02

    摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the aget modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.

    摘要翻译： 公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。 用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。 这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用 的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述琼脂调节所述Robo和Slit多肽的相互作用。 调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。 在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

    Semaphorin receptors
    27.
    发明授权
    Semaphorin receptors 有权
    信号素受体

    公开(公告)号：US06623738B1

    公开(公告)日：2003-09-23

    申请号：US09439711

    申请日：1999-11-12

    申请人： Marc Tessier-Lavigne ,  Zhigang He ,  Hang Chen

    发明人： Marc Tessier-Lavigne ,  Zhigang He ,  Hang Chen

    IPC分类号： A61K39395

    CPC分类号： C07K14/7056 ,  A61K38/00

    摘要： The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers, capable of specifically hybridizing with the disclosed SR genes. SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

    摘要翻译： 本发明提供了与两类信号素受体SR1和SR2相关的方法和组合物。 可以从所公开的SR编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。 本发明提供了能够与所公开的SR基因特异性杂交的分离的SR杂交探针和引物。 SR特异性结合剂，例如特异性抗体，以及在诊断，治疗和生物制药工业中制备和使用本发明组合物的方法。

    Polynucleotide encoding human netrin-1
    28.
    发明授权
    Polynucleotide encoding human netrin-1 有权
    编码人netrin-1的多核苷酸

    公开(公告)号：US06218526B1

    公开(公告)日：2001-04-17

    申请号：US09136981

    申请日：1998-08-20

    申请人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    发明人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    IPC分类号： C12N1518

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.

    摘要翻译： 提供了特异性netrin蛋白质，编码netrin蛋白质的核酸和杂交试剂，能够与netrin基因杂交的探针和引物以及用于筛选用于诊断或治疗疾病相关的不希望的细胞生长的药物的铅化合物的化学文库的方法。 示例性屏幕包括形成包含重组netrin蛋白质，天然细胞内netrin蛋白结合靶标和候选药理学试剂的混合物; 在这样的条件下孵育混合物，但是对于所述候选药理学试剂的存在，所述网蛋白选择性结合所述结合靶; 并检测所述网蛋白与所述结合靶的特异性结合的存在或不存在。

    Human netrin-1
    29.
    发明授权
    Human netrin-1 失效
    人类netrin-1

    公开(公告)号：US5824775A

    公开(公告)日：1998-10-20

    申请号：US635137

    申请日：1996-04-19

    申请人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    发明人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K45/00 ,  A61P25/00 ,  C07K14/47 ,  C07K14/475 ,  C12N15/18 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.

    摘要翻译： 提供了特异性netrin蛋白质，编码netrin蛋白质的核酸和杂交试剂，能够与netrin基因杂交的探针和引物以及用于筛选用于诊断或治疗疾病相关的不希望的细胞生长的药物的铅化合物的化学文库的方法。 示例性屏幕包括形成包含重组netrin蛋白质，天然细胞内netrin蛋白结合靶标和候选药理学试剂的混合物; 在这样的条件下孵育混合物，但是对于所述候选药理学试剂的存在，所述网蛋白选择性结合所述结合靶; 并检测所述网蛋白与所述结合靶的特异性结合的存在或不存在。