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21.发明申请USE OF ARCHAEA TO MODULATE THE NUTRIENT HARVESTING FUNCTIONS OF THE GASTROINTESTINAL MICROBIOTA 审中-公开使用ARCHAEA调节胃肠道微生物的营养功能公开(公告)号：US20100048595A1
公开(公告)日：2010-02-25
申请号：US11909126
申请日：2006-03-22
IPC分类号： A61K31/505 , A61K31/4164 , A61K31/255 , A61K31/195 , A61K31/35 , A61K31/40 , A61K31/404 , A61P3/04
CPC分类号： A61K31/715 , A61K31/04 , A61K31/185 , A61K31/19 , A61K31/192 , A61K31/21 , A61K31/343 , A61K31/35 , A61K31/401 , A61K31/4164 , A61K31/519 , A61K31/7048
摘要： The invention generally relates to the use of archaea to modulate nutrient harvesting in a subject. In particular, the invention provides methods that use archaea to modulate the nutrient harvesting functions of the microbiota in the subject's gastrointestinal tract.
摘要翻译： 本发明一般涉及古细菌调节受试者营养物质收获的用途。 特别地，本发明提供了使用古菌调节受试者的胃肠道中的微生物群的营养物质收获功能的方法。
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公开(公告)号：US5959145A
公开(公告)日：1999-09-28
申请号：US91549
申请日：1993-07-15
IPC分类号： A61K31/20 , A61P31/12 , A61P35/00 , C07C59/125 , C07C59/42 , C07C59/60 , C07C69/675 , C07C323/52 , C07K1/00 , C07K1/107 , C07C53/126
CPC分类号： C07K1/1077 , C07C323/52 , C07C59/125 , C07C59/60 , C07K1/006
摘要： Novel oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.
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公开(公告)号：US5747537A
公开(公告)日：1998-05-05
申请号：US523301
申请日：1995-09-05
IPC分类号： A61K31/20 , A61K31/201 , A61K31/22 , A61K31/23 , C07C57/03 , C07C57/30 , C07C57/42 , C07C59/64 , C07C59/66 , C07C59/68 , C07C255/34 , C07C255/37 , C07D333/24
CPC分类号： C07D333/24 , A61K31/20 , A61K31/201 , A61K31/22 , A61K31/23 , C07C255/34 , C07C255/37 , C07C57/03 , C07C57/30 , C07C57/42 , C07C59/64 , C07C59/66 , C07C59/68
摘要： A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.
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公开(公告)号：US5082967A
公开(公告)日：1992-01-21
申请号：US478298
申请日：1990-02-09
IPC分类号： C12P21/02 , C07C59/125 , C07C59/60 , C07C323/12 , C07C323/52 , C07K1/00 , C07K1/107 , C07K14/00 , C12N9/10 , C12P21/00
CPC分类号： C12N9/1029 , C07C323/12 , C07C323/52 , C07C59/125 , C07C59/60 , C07K1/006 , C07K1/1077
摘要： Novel diheteroatom-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain oxyen and/or sulfur in place of two methylene groups in carbon positions from 3 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid analog or alkyl ester thereof in which said oxygen or sulfur atoms are separated by at least one methylene group.
摘要翻译： 提供了肉豆蔻酰化酶的新型二杂交原子取代的脂肪酸类似物底物，其含有氧和/或硫代替C 13 -C 14脂肪酸类似物或其烷基酯的脂肪酸链中3位至13位的碳位置中的两个亚甲基 其中所述氧或硫原子被至少一个亚甲基分开。
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公开(公告)号：US5073571A
公开(公告)日：1991-12-17
申请号：US402094
申请日：1989-09-01
IPC分类号： A61K31/20 , A61K31/23 , A61P31/12 , C07C59/125 , C07C59/60 , C07C323/52 , C07K1/00
CPC分类号： C07C59/125 , A61K31/20 , A61K31/23 , C07C323/52 , C07C59/60 , C07K1/006
摘要： A method of inhibiting viruses by treatment with oxy- and thio-substituted fatty acid analog substrates of myristoylating enzymes is disclosed. These fatty acid analogs contain an oxygen or sulfur in place of a methylene group in a carbon position from 4 to 13 in the fatty acid chain of a C.sub.13 -C.sub.14 fatty acid or alkyl ester thereof.
摘要翻译： 公开了通过用肉豆蔻酰化酶的氧基和硫取代的脂肪酸类似物底物处理来抑制病毒的方法。 这些脂肪酸类似物在C13-C14脂肪酸或其烷基酯的脂肪酸链中含有氧或硫代替碳原子数为4〜13的亚甲基。
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公开(公告)号：US4778877A
公开(公告)日：1988-10-18
申请号：US103078
申请日：1987-09-30
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
摘要翻译： 公开了具有如下氨基酸序列或其生理上可接受的酰胺或盐衍生物的肉豆蔻酰化酶的八肽抑制剂：
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