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310 条记录 (耗时 0.104 秒)

    Human chemotactic cytokine I polypeptides
    21.
    发明申请
    Human chemotactic cytokine I polypeptides 审中-公开
    人类趋化性细胞因子I多肽

    公开(公告)号：US20050069945A1

    公开(公告)日：2005-03-31

    申请号：US10994821

    申请日：2004-11-23

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Su

    IPC分类号： C07H21/04 ,  C07K14/52 ,  C12P21/02 ,  C12Q1/68

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Tumor necrosis factor receptors 6α and 6β
    23.
    发明授权
    Tumor necrosis factor receptors 6α and 6β 失效
    肿瘤坏死因子受体6α和6＆bgr;

    公开(公告)号：US08003386B1

    公开(公告)日：2011-08-23

    申请号：US09006352

    申请日：1998-01-13

    申请人： Reiner Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    发明人： Reiner Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    IPC分类号： C12N15/28 ,  C12N15/09 ,  C12N15/06 ,  C12N15/12 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α＆-6＆bgr的分离的核酸分子; 蛋白质。 TNFR-6α＆-6＆bgr; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。 活动。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA
    25.
    发明申请
    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 审中-公开
    使用抗体治疗中耳炎的方法

    公开(公告)号：US20100330073A1

    公开(公告)日：2010-12-30

    申请号：US12870394

    申请日：2010-08-27

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P35/00 ,  C07K16/18

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Use of an antibody that binds human tumor necrosis factor receptor-like 2
    26.
    发明授权
    Use of an antibody that binds human tumor necrosis factor receptor-like 2 有权
    使用结合人类肿瘤坏死因子受体的抗体2

    公开(公告)号：US07824675B2

    公开(公告)日：2010-11-02

    申请号：US12241203

    申请日：2008-09-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/2878 ,  C07K2317/73 ,  C07K2319/30

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    TRANSFORMING GROWTH FACTOR ALPHA HII
    28.
    发明申请
    TRANSFORMING GROWTH FACTOR ALPHA HII 审中-公开
    转化生长因子ALPHA HII

    公开(公告)号：US20100130417A1

    公开(公告)日：2010-05-27

    申请号：US12495569

    申请日：2009-06-30

    申请人： Ying-Fei Wei ,  Paul S. Meissner ,  Jian Ni

    发明人： Ying-Fei Wei ,  Paul S. Meissner ,  Jian Ni

    IPC分类号： A61K38/16 ,  C07H21/02 ,  C12N15/74 ,  C12N1/21 ,  C12P21/02 ,  C07K14/00 ,  C07K16/00 ,  A61K31/7088 ,  G01N33/53 ,  A61P31/04

    CPC分类号： A61K38/1841 ,  A61K48/00 ,  C07K14/495 ,  Y10T436/143333

    摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

    摘要翻译： 本发明公开了转化生长因子αHII多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病，以及刺激胚胎发生和血管发生。 还公开了抗这些多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。