公开(公告)号：US5042144A

公开(公告)日：1991-08-27

申请号：US411416

申请日：1989-09-22

申请人： Jin Shimada ,  Douglas W. Fletcher

发明人： Jin Shimada ,  Douglas W. Fletcher

IPC分类号： A61B5/0408 ,  A61N1/04

CPC分类号： A61N1/0496 ,  A61B5/04087 ,  A61B2562/125 ,  A61N1/046 ,  Y10T29/49117 ,  Y10T29/4921 ,  Y10T29/49222

摘要： A method of forming a conductive lamina for use with and to form a bio-medical electrode device comprising the steps of providing a non-conductive base structure, providing a mixture of an electrically conductive substance and a media component, depositing the mixture onto the base structure, and curing the mixture. The method further comprises the step of mixing the electrical conductant and the media component in a closed cell, positive pressure kinetic mixer. The method further comprises the steps of combining a urethane base and a polyhydric alcohol to form the media component and delaying the mixing of the media component and the electrical conductant for a predetermined time period. In another embodiment, the method comprises the steps of combining a photo-initiator, a cross-linking agent, and low pH acrylic monomers to form a precomponent, and mixing the precomponent with the glycol to form the media component. The method further comprises the step of cooling the mixture prior to depositing it onto the base structure, and exposing the mixture to ultraviolet energy for a predetermined time period.

摘要翻译： 一种用于形成生物医用电极器件的形成导电层的方法，包括以下步骤：提供非导电性基底结构，提供导电物质和介质成分的混合物，将混合物沉积在基底上 结构和固化混合物。 该方法还包括将电导体和介质组分混合在闭孔，正压动力学混合器中的步骤。 该方法还包括将氨基甲酸酯基和多元醇组合以形成介质组分并延迟介质组分和电导体在预定时间段内的混合的步骤。 在另一个实施方案中，该方法包括以下步骤：将光引发剂，交联剂和低pH丙烯酸单体组合以形成预组分，并将预组分与二醇混合以形成介质组分。 该方法还包括在将混合物沉积到基底结构上之前将混合物冷却并将混合物暴露于紫外线能量预定时间段的步骤。

公开(公告)号：US20150209576A1

公开(公告)日：2015-07-30

申请号：US14165559

申请日：2014-01-27

申请人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

发明人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0563

摘要： Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications. Defibrillation pulses can be transmitted through less cross-sectional area of metal in the subject fine wire conductor than would be the case with conventional solid core metal wires. Multiple such coated fibers can act as a single conductor. An outer protective sheath of a flexible polymer material can be included.

摘要翻译： 旨在用于电刺激和感测装置的可植入医疗设备通常将一个或多个电导体作为引线用于电刺激或从身体中的离散点（例如心脏）检索局部感测数据。 某些应用需要输送高强度电脉冲，即CRT或除颤器。 如本文所述，CRT通过由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成的耐用细线引脚提供高能量脉冲。 单极电导体可以具有约150微米或甚至更小的外径。 缓冲的纤维支持内部或外部除颤器或其他生物医学应用以及非医疗应用所需的高强度电脉冲的传导。 除了传统的固体芯金属线材外，除颤脉冲可以通过较小的细线导体中金属的横截面积传递。 多个这样的涂覆纤维可以用作单个导体。 可以包括柔性聚合物材料的外护套。

公开(公告)号：US08692117B2

公开(公告)日：2014-04-08

申请号：US12804271

申请日：2010-07-16

申请人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

发明人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

IPC分类号： H01B11/00 ,  H01B7/04 ,  A61N1/05

CPC分类号： H01B9/005 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/056 ,  H01B1/14 ,  H01B1/18 ,  H01B7/04 ,  H01B7/048

摘要： Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.

摘要翻译： 耐用的细线电导体坚固耐用，外形小巧，重量轻，但能够在极端环境条件下工作。 由具有金属涂层和一个或多个聚合物层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成，单极电导体可以具有小至约300微米甚至更小的外径。 金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。 所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。 双极电导体可以包括并排存在的几个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘的金属导电路径同轴。 可以包括柔性聚合物材料的外护套。

公开(公告)号：US20120157916A1

公开(公告)日：2012-06-21

申请号：US13403420

申请日：2012-02-23

申请人： Chris Quinn ,  Jin Shimada

发明人： Chris Quinn ,  Jin Shimada

IPC分类号： A61M25/10

CPC分类号： A61M25/04 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/22044 ,  A61M25/0147 ,  A61M2025/0161

摘要： A method for accessing the left atrial appendage with a balloon-tipped transseptal sheath is disclosed. A transseptal sheath is delivered to the left atrium through the intraatrial septum from the right atrium. The balloon tip may be inflated to prevent the transseptal sheath from falling proximally into the right atrium. The inflated balloon tip permits safe probing and exploration of the left atrial appendage and facilitates safe maintenance of the position of the transseptal sheath within the left atrial appendage while delivering an implantable device to the left atrial appendage.

摘要翻译： 公开了一种用球囊穿透的外套进入左心耳的方法。 经心外膜通过右心房的宫内隔膜输送到左心房。 气囊末端可以被充气以防止经血管鞘向近侧落入右心房。 膨胀的气囊尖端允许对左心耳的安全探测和探查，并且有助于安全地维持左心耳内的经血管鞘的位置，同时将可植入装置递送到左心耳。

公开(公告)号：US20120029553A1

公开(公告)日：2012-02-02

申请号：US13270778

申请日：2011-10-11

申请人： Chris Quinn ,  Jin Shimada ,  Kevin Anderson

发明人： Chris Quinn ,  Jin Shimada ,  Kevin Anderson

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12122 ,  A61B17/12172 ,  A61B90/39 ,  A61B2017/12054 ,  A61B2017/12081 ,  A61B2017/12095 ,  A61B2017/22035 ,  A61B2090/08021 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071

摘要： A system and method for retrieving an implantable device includes a delivery catheter, a recapture section, and a sheath. The delivery catheter has a proximal end and a distal end. The recapture section is axially extendable from the distal end of the delivery catheter. The sheath has a proximal end and a distal end and a lumen sized to receive the delivery catheter. A portion of the lumen of the sheath is actuatable from an enlarged inside diameter to a reduced inside diameter to apply an inwardly directed force to the recapture section. The delivery catheter can be actuated with respect to the sheath to extend or retract the recapture section with respect to the delivery catheter.

摘要翻译： 用于检索可植入装置的系统和方法包括输送导管，再捕获部分和护套。 输送导管具有近端和远端。 再捕获部分可从输送导管的远端轴向延伸。 护套具有近端和远端以及尺寸适于接纳输送导管的内腔。 护套的内腔的一部分可以从扩大的内径致动到减小的内径，以向再取回部分施加向内的力。 输送导管可以相对于护套被致动以相对于输送导管延伸或缩回再捕获部分。

公开(公告)号：US20090036965A1

公开(公告)日：2009-02-05

申请号：US11830410

申请日：2007-07-30

申请人： ROBERT GLENMORE WALSH ,  Jin Shimada

发明人： ROBERT GLENMORE WALSH ,  Jin Shimada

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61F2/2493 ,  A61F2250/0067

摘要： A conjunctive method of treating coronary artery disease includes a primary treatment where a stent is placed in a coronary artery of a patient at a site of an occlusion. The conjunctive method comprises placing a therapeutic agent at an epicardial surface of a heart of the patient and at the site of the occlusion. The therapeutic agent is selected for abating restenosis at the site.

摘要翻译： 治疗冠状动脉疾病的联合方法包括主要治疗，其中支架置于患者的闭塞部位的冠状动脉中。 联合方法包括将治疗剂置于患者心脏的心外膜表面和闭塞部位。 选择治疗剂以减轻现场的再狭窄。

公开(公告)号：US20060074397A1

公开(公告)日：2006-04-06

申请号：US11238390

申请日：2005-09-29

申请人： Jin Shimada

发明人： Jin Shimada

IPC分类号： A61M31/00

CPC分类号： A61B17/3421 ,  A61B17/00234 ,  A61B17/221 ,  A61B17/3423 ,  A61B17/3498 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/22067 ,  A61B2017/2215 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61B2090/08021 ,  A61M25/10 ,  A61M39/0247

摘要： A method of accessing the pericardial space comprises providing a primary catheter having an inflatable balloon, inserting the primary catheter into the vascular system, forwarding the primary catheter through the vascular system to an atrial appendage, inflating the balloon to engage the wall of the appendage sufficient to separate opposing wall portions of the appendage between the cardiac tissue and the pericardium. The inflated balloon increases the distance of the pericardium from the cardiac tissue to permit easier access into the pericardial space via the appendage. The inflated balloon further can be configured to create a seal of the balloon exterior surface relative to an inner wall of the appendage adjacent to an apex of the appendage. The balloon seal isolates a portion of the interior of the appendage adjacent the apex allowing the removal of blood from the isolated portion. This prevents cross-contamination of fluid between the pericardial space and the appendage. An implantable valve positionable in the apex of the appendage permits repeatable access into the pericardial space.

公开(公告)号：US5087242A

公开(公告)日：1992-02-11

申请号：US383939

申请日：1989-07-21

申请人： Tomasz J. Petelenz ,  Stephen C. Jacobsen ,  Robert L. Stephen ,  Jon Beck ,  Jin Shimada

发明人： Tomasz J. Petelenz ,  Stephen C. Jacobsen ,  Robert L. Stephen ,  Jon Beck ,  Jin Shimada

IPC分类号： A61M37/00 ,  A61N1/04 ,  A61N1/30

CPC分类号： A61N1/0436

摘要： A hydratable iontophoretic bioelectrode includes a layer of material for absorbing and holding an ionized fluid when placed in contact with the fluid. A conductive sheet of material is positioned in contact with one side of the layer of material and is connectable to an electrical charged source to receive a charge of the same polarity as the polarity of ions in the fluid. A support base holds the layer of material and conductive sheets in place to enable placement of the layer of material against the skin or tissue of a person into which ions from the ionized fluid are to be delivered. This is carried out by applying the charge in question to the conductive sheet to cause the ions in the layer of material to migrate therefrom into the person's skin or tissue.

公开(公告)号：US09513443B2

公开(公告)日：2016-12-06

申请号：US14331200

申请日：2014-07-14

申请人： John Lawrence Erb ,  Stephen Sundquist ,  James Edward Shapland ,  Robert Glenmore Walsh ,  Jin Shimada

发明人： John Lawrence Erb ,  Stephen Sundquist ,  James Edward Shapland ,  Robert Glenmore Walsh ,  Jin Shimada

IPC分类号： A61N1/05 ,  G02B6/38 ,  G02B6/44

CPC分类号： G02B6/3817 ,  A61N1/05 ,  G02B6/4416

摘要： A small diameter, shielded, fine wire glass fiber conductor which is capable of transmitting optical and electrical signals in environments with electromagnetic interference or radio frequency interferences. The conductor includes a fiber core, a first insulation layer, a conductive layer, a second insulation layer, a shielding layer, and an outer coating. Applications include use in aerospace, automotive, and other vehicles as well as potential use in electrostimulation devices, such as pacemaker leads, vascular guidewires and other medical applications.

摘要翻译： 一种小直径，屏蔽，细线玻璃光纤导体，能够在具有电磁干扰或射频干扰的环境中传输光信号和电信号。 导体包括纤维芯，第一绝缘层，导电层，第二绝缘层，屏蔽层和外涂层。 应用包括在航空航天，汽车和其他车辆中的应用，以及潜在的电刺激装置，如起搏器引线，血管导丝线和其他医疗应用。

公开(公告)号：US20150262733A1

公开(公告)日：2015-09-17

申请号：US14184580

申请日：2014-02-19

申请人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

发明人： Robert G. Walsh ,  Jin Shimada ,  Scott Engle

IPC分类号： H01B9/00 ,  A61N1/05 ,  H01B7/04 ,  H01B1/18 ,  H01B1/14

CPC分类号： H01B9/005 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/056 ,  H01B1/14 ,  H01B1/18 ,  H01B7/04 ,  H01B7/048

摘要： Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.

摘要翻译： 耐用的细线电导体坚固耐用，外形小巧，重量轻，但能够在极端环境条件下工作。 由具有金属涂层和一个或多个聚合物层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成，单极电导体可以具有小至约300微米甚至更小的外径。 金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。 所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。 双极电导体可以包括并排存在的几个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘的金属导电路径同轴。 可以包括柔性聚合物材料的外护套。