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63 条记录 (耗时 0.037 秒)

    Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them
    21.
    发明授权
    Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them 失效
    磺酰胺取代的稠合的7-元环化合物，它们作为药物的用途，以及包含它们的药物制剂

    公开(公告)号：US06908947B2

    公开(公告)日：2005-06-21

    申请号：US09983670

    申请日：2001-10-25

    申请人： Joachim Brendel ,  Hans Jochen Lang ,  Uwe Gerlach

    发明人： Joachim Brendel ,  Hans Jochen Lang ,  Uwe Gerlach

    IPC分类号： A61P9/00 ,  C07C311/07 ,  C07D313/08 ,  A61K31/16 ,  A61K31/18 ,  C07C303/00 ,  C07C381/00

    CPC分类号： C07D313/08 ,  C07C311/07 ,  C07C2602/12

    摘要： The present invention relates to compounds of formula I, in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compounds effect the potassium channel or the IKs channel opened by cyclic adenosine monophosphate (cAMP) and are outstandingly suitable as pharmaceutical active compounds, for example for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.

    摘要翻译： 本发明涉及式Ⅰ化合物，其中X1，X2，X3，X4，Y1，Y2，Y3，Y4，R（3），R（4）和R（5） 他们的准备和使用，特别是在药物。 这些化合物影响由环磷酸腺苷（cAMP）打开的钾通道或IκS通道，并且非常适合作为药物活性化合物，例如用于预防和治疗心血管疾病，特别是心律失常， 用于治疗胃肠道区域的溃疡或用于治疗腹泻病症。

    Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
    29.
    发明授权
    Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them 失效
    即，间位取代的双芳基化合物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂

    公开(公告)号：US06605625B2

    公开(公告)日：2003-08-12

    申请号：US09995771

    申请日：2001-11-29

    申请人： Stefan Peukert ,  Joachim Brendel ,  Horst Hemmerle ,  Heinz-Werner Kleemann

    发明人： Stefan Peukert ,  Joachim Brendel ,  Horst Hemmerle ,  Heinz-Werner Kleemann

    IPC分类号： C07D21381

    CPC分类号： C07D213/79 ,  C07C235/34 ,  C07C271/22 ,  C07D213/81 ,  C07D213/82

    摘要： Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I in which: A1, A2, A3, A4, A5, A6, A7 and A8 independently of one another are chosen from nitrogen, CH and CR(5), at least four of these groups being CH, and wherein all other variables are as defined here.

    摘要翻译： 正交的，间位取代的二芳基化合物，其制备方法，它们作为药物的用途，以及药物制剂，包括它们作为抗心律失常活性化合物的用途，例如用于治疗和预防心房心律失常，例如。 心房颤动（AF）或心房扑动。 本发明的化合物包括式Iin的化合物，其中：A1，A2，A3，A4，A5，A6，A7和A8彼此独立地选自氮，CH和CR（5），这些基团中的至少四个为 CH，并且其中所有其他变量如这里所定义。