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公开(公告)号：US20070186567A1
公开(公告)日：2007-08-16
申请号：US11702472
申请日：2007-02-05
IPC分类号： F25C1/00
CPC分类号： F26B5/06
摘要： Methods of inducing nucleation of a material is provided. The disclosed methods comprise the steps of bringing the material to a temperature near or below a phase transition temperature and altering the pressure to induce nucleation of the material. The disclosed methods are useful in freeze-drying processes, particularly pharmaceutical freeze-drying processes.
摘要翻译： 提供了诱导材料成核的方法。 所公开的方法包括使材料达到接近或低于相变温度的温度并改变压力以诱导材料成核的步骤。 所公开的方法在冷冻干燥方法，特别是药物冷冻干燥方法中是有用的。
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公开(公告)号：US20240189344A1
公开(公告)日：2024-06-13
申请号：US18064406
申请日：2022-12-12
申请人： Sameer H. Israni , Balazs Hunek
发明人： Sameer H. Israni , Balazs Hunek
摘要： Disclosed are methods of reducing incidence of disorders such as Woody Breast in poultry, by incubating pre-hatching eggs in an atmosphere enriched in carbon dioxide, preferably combined with administration to the post-hatching birds of water comprising oxygen-containing nanobubbles.
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公开(公告)号：US20240188592A1
公开(公告)日：2024-06-13
申请号：US18064376
申请日：2022-12-12
申请人： Sameer H. Israni , Balazs Hunek
发明人： Sameer H. Israni , Balazs Hunek
IPC分类号： A23K50/75 , A23K20/20 , B01F23/2373 , B82Y40/00
CPC分类号： A23K50/75 , A23K20/20 , B01F23/2373 , B82Y40/00
摘要： Administration to chickens or other poultry of water containing nanobubbles that contain oxygen reduces the incidence of woody breast disorder in the chicken or other poultry.
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24.发明授权Bioreactor with upward flowing impeller system for use in a mammalian cell culture process 有权具有向上流动的叶轮系统的生物反应器用于哺乳动物细胞培养过程公开(公告)号：US09181521B2
公开(公告)日：2015-11-10
申请号：US13559957
申请日：2012-07-27
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
CPC分类号： C12M27/20 , C12M27/02 , C12M27/24 , C12M29/06 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N1/38
摘要： A bioreactor with an upward flowing impeller system for controlling a mammalian cell culture process is provided. The disclosed system enables control of the cell culture process by controlling the level of dissolved carbon dioxide in the cell culture media and prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide via surface gas exchange with little or no damage to the mammalian cells. The use of an upward flow impeller combined with vertical baffles converts the swirling motions of the cell culture media into a largely vertical flow and promotes the removal of dissolved carbon dioxide via surface gas exchange with a sweep gas flowing over the top surface of the cell culture media within the bioreactor vessel.
摘要翻译： 提供了一种具有向上流动的叶轮系统用于控制哺乳动物细胞培养过程的生物反应器。 所公开的系统能够通过控制细胞培养基中溶解的二氧化碳的水平来控制细胞培养过程，并且通过经由表面气体交换增强汽提二氧化碳来实现渗透压浓度的增加，对哺乳动物几乎没有或没有损伤 细胞。 使用与垂直挡板结合的向上流动叶轮将细胞培养基的旋转运动转化为大体垂直的流动，并通过与流过细胞培养物顶表面的吹扫气体的表面气体交换促进去除溶解的二氧化碳 生物反应器容器内的介质。
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公开(公告)号：US20100242301A1
公开(公告)日：2010-09-30
申请号：US12414760
申请日：2009-03-31
CPC分类号： F26B5/06
摘要： A freeze-dryer and method of controlling the same is provided. The disclosed freeze-dryer includes a chamber adapted to hold material or product to be freeze-dried; one or more depressurization orifices; a gas pressurization circuit having a source of gas to pressurize the chamber to a prescribed pressure; a depressurization circuit coupled to the chamber via the one or more orifices and having a depressurizing control valve; and a control unit adapted to pressurize the chamber with the source of gas and actuate the depressurizing control valve to depressurize the chamber upon command. The ratio of total depressurization orifice area to the chamber volume is preferably between about 6×10−2 and about 4×10−4 m2/m3.
摘要翻译： 提供了一种冷冻干燥机及其控制方法。 所公开的冷冻干燥机包括适于容纳要冷冻干燥的材料或产品的室; 一个或多个减压孔; 气体加压回路，其具有用于将所述腔室加压到规定压力的气体源; 减压回路，经由所述一个或多个孔连接到所述腔室并具有减压控制阀; 以及控制单元，其适于利用所述气体源对所述室加压并且致动所述减压控制阀以在命令时对所述室进行减压。 总减压孔面积与室容积的比优选在约6×10 -2至约4×10 -4 m 2 / m 3之间。
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公开(公告)号：US20230070030A1
公开(公告)日：2023-03-09
申请号：US17872477
申请日：2022-07-25
申请人： Sameer H. Israni , Balazs Hunek
发明人： Sameer H. Israni , Balazs Hunek
摘要： Incubating eggs of chicken or other poultry in an atmosphere in which the CO2 concentration is elevated at controlled levels, enhances the health and survivability of the chicks and, in the case of chickens, reduces the tendency of chicks hatched from the eggs thus treated to disorders such as Woody Breast.
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公开(公告)号：US20140308423A1
公开(公告)日：2014-10-16
申请号：US14315086
申请日：2014-06-25
IPC分类号： A23G9/46
摘要： Disclosed are methods and apparatus for forming frozen foam products, including edible products, using air or gases or gas mixtures having an average molecular weight larger than that of air, wherein the products contain bubbles having a reduced average size preferably in a narrow size range.
摘要翻译： 公开了使用平均分子量大于空气的空气或气体或气体混合物形成冷冻泡沫产品的方法和设备，包括食用产品，其中产品含有平均尺寸较小的气泡，优选地在窄尺寸范围内。
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公开(公告)号：US08241904B2
公开(公告)日：2012-08-14
申请号：US12536559
申请日：2009-08-06
申请人： Alan T. Y. Cheng , Ying Zhou , Balazs Hunek , Amitabh Gupta , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Balazs Hunek , Amitabh Gupta , Nigel Grinter
IPC分类号： C12N5/02
摘要： A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow.
摘要翻译： 提供了一种用于控制哺乳动物细胞培养方法的系统和方法。 细胞培养过程的这种控制涉及控制细胞培养基中溶解的二氧化碳的水平，并且通过增强对二氧化碳的去除而对哺乳动物细胞几乎没有或没有损伤来实现所产生的渗透压浓度增加的能力。 所公开的溶解二氧化碳汽提方法和系统包括通过使用与垂直挡板结合的向上流动叶轮将生物反应器容器内的表面气体交换机制改进为将液体的旋转运动转化成大体垂直的流动。
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公开(公告)号：US08240065B2
公开(公告)日：2012-08-14
申请号：US12414760
申请日：2009-03-31
CPC分类号： F26B5/06
摘要： A freeze-dryer and method of controlling the same is provided. The disclosed freeze-dryer includes a chamber adapted to hold material or product to be freeze-dried; one or more depressurization orifices; a gas pressurization circuit having a source of gas to pressurize the chamber to a prescribed pressure; a depressurization circuit coupled to the chamber via the one or more orifices and having a depressurizing control valve; and a control unit adapted to pressurize the chamber with the source of gas and actuate the depressurizing control valve to depressurize the chamber upon command. The ratio of total depressurization orifice area to the chamber volume is preferably between about 6×10−2 and about 4×10−4 m2/m3.
摘要翻译： 提供了一种冷冻干燥机及其控制方法。 所公开的冷冻干燥机包括适于容纳要冷冻干燥的材料或产品的室; 一个或多个减压孔; 气体加压回路，其具有用于将所述腔室加压到规定压力的气体源; 减压回路，经由所述一个或多个孔连接到所述腔室并具有减压控制阀; 以及控制单元，其适于利用所述气体源对所述室加压并且致动所述减压控制阀以在命令时对所述室进行减压。 总减压孔面积与室容积的比优选在约6×10 -2至约4×10 -4 m 2 / m 3之间。
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30.发明授权Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield 有权用于在哺乳动物细胞培养过程中控制pH，重量摩尔渗透压浓度和溶解二氧化碳水平以增强细胞活力和生物产物产率的方法公开(公告)号：US08178318B2
公开(公告)日：2012-05-15
申请号：US12702428
申请日：2010-02-09
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
IPC分类号： C12P21/02
CPC分类号： C12N5/0018 , C12N1/38 , C12N2500/02 , C12N2500/60
摘要： Methods for controlling the level of dissolved carbon dioxide and limiting osmolality in a mammalian cell culture process to enhance cell growth, viability and density, and increase biologic product concentration and yield are provided. Such control of the level of dissolved carbon dioxide and pH as well as the resulting ability to limit osmolality in a mammalian cell culture process is achieved by adopting alternative pH control strategies and CO2 stripping techniques during a mammalian cell culture process. Such pH control techniques and carbon dioxide stripping occur without foam and with little or no damage to the mammalian cells.
摘要翻译： 提供了用于在哺乳动物细胞培养过程中控制溶解二氧化碳水平和限制重量克分子渗透浓度以增强细胞生长，活力和密度以及提高生物产物浓度和产量的方法。 通过在哺乳动物细胞培养过程中采用替代的pH控制策略和CO 2汽提技术来实现对哺乳动物细胞培养过程中溶解的二氧化碳和pH的水平的控制以及所产生的限制重量克分子渗透浓度的能力。 这种pH控制技术和二氧化碳汽提不发生泡沫，对哺乳动物细胞几乎没有或没有损害。
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