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25 条记录 (耗时 0.028 秒)

    Human G-protein coupled receptor, HGPRBMY11, and variants thereof
    21.
    发明申请
    Human G-protein coupled receptor, HGPRBMY11, and variants thereof 有权
    人G蛋白偶联受体，HGPRBMY11及其变体

    公开(公告)号：US20060229272A1

    公开(公告)日：2006-10-12

    申请号：US11403051

    申请日：2006-04-12

    申请人： Lauren Barber ,  Angela Cacace ,  John Feder ,  Thomas Nelson ,  David Bol ,  Chandra Ramanathan

    发明人： Lauren Barber ,  Angela Cacace ,  John Feder ,  Thomas Nelson ,  David Bol ,  Chandra Ramanathan

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY11 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of the HGPRBMY11 polypeptide, HGPRBMY11v1 and HGPRBMY11v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY11, HGPRBMY11v1, and/or HGPRBMY11v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders, Crohn's disease, ovarian cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HGPRBMY11多肽，其片段和同源物的新型多核苷酸。 本发明还提供编码HGPRBMY11多肽，HGPRBMY11v1和HGPRBMY11v2变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY11，HGPRBMY11v1和/或HGPRBMY11v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是胃肠道疾病和/或 疾病，克罗恩病，卵巢癌以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof
    23.
    发明申请
    Polynucleotide encoding a novel TRP channel family member, TRP-PLIK2, and splice variants thereof 有权
    编码新型TRP通道家族成员的多核苷酸，TRP-PLIK2及其剪接变体

    公开(公告)号：US20070172880A1

    公开(公告)日：2007-07-26

    申请号：US11726234

    申请日：2007-03-21

    申请人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    发明人： Ning Lee ,  Jian Chen ,  John Feder ,  Shujian Wu ,  Han Chang ,  Liana Lee ,  Michael Blanar ,  David Bol

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。 本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法 多肽。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Human coactivator-associated arginine methyltransferase 1 (hCARM1)
    24.
    发明申请
    Human coactivator-associated arginine methyltransferase 1 (hCARM1) 审中-公开
    人共激活因子相关精氨酸甲基转移酶1（hCARM1）

    公开(公告)号：US20050196753A1

    公开(公告)日：2005-09-08

    申请号：US10449370

    申请日：2003-05-30

    申请人： Lata Jayaraman ,  Rolf Ryseck ,  Matthew Lorenzi ,  David Bol

    发明人： Lata Jayaraman ,  Rolf Ryseck ,  Matthew Lorenzi ,  David Bol

    IPC分类号： C07H21/04 ,  C12N5/06 ,  C12N9/10 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/53

    CPC分类号： C12N9/1007

    摘要： Human coactivator-associated arginine methyltransferase 1 (hCARM1) polynucleotides and polypeptides. Also provided are expression vectors, recombinant host cells and processes for producing recombinant host cells, processes for producing said polypeptides, and methods for identifying substances that are capable of interacting with a coactivator-associated arginine methyltransferase 1 molecule.

    摘要翻译： 人共激活因子相关的精氨酸甲基转移酶1（hCARM1）多核苷酸和多肽。 还提供了表达载体，重组宿主细胞和用于产生重组宿主细胞的方法，用于产生所述多肽的方法，以及用于鉴定能够与共激活因子相关的精氨酸甲基转移酶1分子相互作用的物质的方法。