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54 条记录 (耗时 0.067 秒)

    Human G-protein coupled receptor, HGPRBMY11, and variants thereof
    1.
    发明申请
    Human G-protein coupled receptor, HGPRBMY11, and variants thereof 有权
    人G蛋白偶联受体，HGPRBMY11及其变体

    公开(公告)号：US20060229272A1

    公开(公告)日：2006-10-12

    申请号：US11403051

    申请日：2006-04-12

    申请人： Lauren Barber ,  Angela Cacace ,  John Feder ,  Thomas Nelson ,  David Bol ,  Chandra Ramanathan

    发明人： Lauren Barber ,  Angela Cacace ,  John Feder ,  Thomas Nelson ,  David Bol ,  Chandra Ramanathan

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY11 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of the HGPRBMY11 polypeptide, HGPRBMY11v1 and HGPRBMY11v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY11, HGPRBMY11v1, and/or HGPRBMY11v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders, Crohn's disease, ovarian cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码HGPRBMY11多肽，其片段和同源物的新型多核苷酸。 本发明还提供编码HGPRBMY11多肽，HGPRBMY11v1和HGPRBMY11v2变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY11，HGPRBMY11v1和/或HGPRBMY11v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是胃肠道疾病和/或 疾病，克罗恩病，卵巢癌以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    POLYNUCLEOTIDE ENCODING A NOVEL ACYL COENZYME A, MONOACYLGLYCEROL ACYLTRANSFERASE-3 (MGAT3), AND USES THEREOF
    5.
    发明申请
    POLYNUCLEOTIDE ENCODING A NOVEL ACYL COENZYME A, MONOACYLGLYCEROL ACYLTRANSFERASE-3 (MGAT3), AND USES THEREOF 审中-公开
    多核苷酸编码新型ACYL COENZYME A，单乙酰胆碱酯酶3（MGAT3）及其用途

    公开(公告)号：US20080019958A1

    公开(公告)日：2008-01-24

    申请号：US11779308

    申请日：2007-07-18

    申请人： John Feder ,  Thomas Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    发明人： John Feder ,  Thomas Nelson ,  Jian Chen ,  Rupalie Meegalla ,  Michael Ramaker ,  Dong Cheng

    IPC分类号： C07K16/18 ,  A61K38/45 ,  C12N1/00 ,  C12P21/02 ,  C12Q1/48 ,  C12N9/10 ,  A61P1/00

    CPC分类号： C12N9/1029

    摘要： The present invention provides novel polynucleotides encoding MGAT3 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MGAT3 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as obesity. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MGAT3多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MGAT3多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症如肥胖症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42
    7.
    发明申请
    Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
    编码新型睾丸特异性微管蛋白酪氨酸连接酶样蛋白的多核苷酸BGS42

    公开(公告)号：US20060246051A1

    公开(公告)日：2006-11-02

    申请号：US11445988

    申请日：2006-06-02

    申请人： John Feder ,  Shujian Wu ,  Thomas Nelson

    发明人： John Feder ,  Shujian Wu ,  Thomas Nelson

    IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  A61K38/48 ,  C12N9/64 ,  G01N33/53 ,  C07K16/40

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/57423 ,  G01N2333/9015 ,  Y10S435/81

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides and polypeptides encoding a novel metalloprotease, Protease-40b
    8.
    发明申请
    Polynucleotides and polypeptides encoding a novel metalloprotease, Protease-40b 审中-公开
    编码新的金属蛋白酶的多核苷酸和多肽，蛋白酶-40b

    公开(公告)号：US20050118632A1

    公开(公告)日：2005-06-02

    申请号：US10980669

    申请日：2004-11-03

    申请人： Jian Chen ,  Stanley Krystek ,  John Feder ,  Thomas Nelson

    发明人： Jian Chen ,  Stanley Krystek ,  John Feder ,  Thomas Nelson

    IPC分类号： C12N9/64 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/6489

    摘要： The present invention provides novel polynucleotides encoding Protease-40b polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel Protease-40b polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码蛋白酶-40b多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型蛋白酶-40b多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel human Kupffer cell receptor protein, BGS-18
    10.
    发明申请
    Polynucleotides encoding a novel human Kupffer cell receptor protein, BGS-18 审中-公开
    编码新型人类枯否细胞受体蛋白BGS-18的多核苷酸

    公开(公告)号：US20060003367A1

    公开(公告)日：2006-01-05

    申请号：US11152697

    申请日：2005-06-14

    申请人： Shujian Wu ,  John Feder ,  Thomas Nelson

    发明人： Shujian Wu ,  John Feder ,  Thomas Nelson

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The present invention provides novel polynucleotides encoding BGS-18 polypeptide, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-18 polypeptide to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码BGS-18多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-18多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。