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公开(公告)号：US20060229272A1
公开(公告)日：2006-10-12
申请号：US11403051
申请日：2006-04-12
申请人： Lauren Barber , Angela Cacace , John Feder , Thomas Nelson , David Bol , Chandra Ramanathan
发明人： Lauren Barber , Angela Cacace , John Feder , Thomas Nelson , David Bol , Chandra Ramanathan
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding HGPRBMY11 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of the HGPRBMY11 polypeptide, HGPRBMY11v1 and HGPRBMY11v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY11, HGPRBMY11v1, and/or HGPRBMY11v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders, Crohn's disease, ovarian cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY11多肽，其片段和同源物的新型多核苷酸。 本发明还提供编码HGPRBMY11多肽，HGPRBMY11v1和HGPRBMY11v2变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY11，HGPRBMY11v1和/或HGPRBMY11v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是胃肠道疾病和/或 疾病，克罗恩病，卵巢癌以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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2.发明申请Novel human G-protein coupled receptor, HGPRBMY23, expressed highly in kidney 有权新型人类G蛋白偶联受体HGPRBMY23在肾脏中表达很高公开(公告)号：US20080014593A1
公开(公告)日：2008-01-17
申请号：US11897997
申请日：2007-08-31
申请人： Lauren Barber , Angela Cacace , John Feder , Thomas Nelson , Chandra Ramanathan , Rolf-Peter Ryseck , Michael Neubauer , Michael Kornacker
发明人： Lauren Barber , Angela Cacace , John Feder , Thomas Nelson , Chandra Ramanathan , Rolf-Peter Ryseck , Michael Neubauer , Michael Kornacker
IPC分类号： C12Q1/68
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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3.发明申请Identification and modulation of a G-protein coupled receptor (GPCR), RAI3, associated with chronic obstructive pulmonary disease (COPD) and NF-KB and E-selectin regulation 有权与慢性阻塞性肺疾病（COPD）和NF-κB和E-选择蛋白调节相关的G蛋白偶联受体（GPCR），RAI3的鉴定和调节公开(公告)号：US20070259373A1
公开(公告)日：2007-11-08
申请号：US11809905
申请日：2007-05-31
申请人： Gena Whitney , Gregory Opiteck , Leah Garulacan , Chandra Ramanathan , Murray McKinnon , Kelly Bennett , Lauren Barber , Angela Cacace , Zenta Tsuchihashi , John Feder
发明人： Gena Whitney , Gregory Opiteck , Leah Garulacan , Chandra Ramanathan , Murray McKinnon , Kelly Bennett , Lauren Barber , Angela Cacace , Zenta Tsuchihashi , John Feder
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/705 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5023 , G01N33/5041 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/574 , G01N33/6884 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2800/122
摘要： The present invention describes a G-protein coupled receptor (GPCR) family member newly identified as being modified, e.g., phosphorylated, and associated with tyrosine phosphorylated activation complexes, following exposure of cells to smoke from tobacco burning substances, namely, cigarette smoke. This GPCR protein is RAI-3, which was first found to be phosphorylated in cells treated with cigarette smoke and to be associated with other proteins activated in cigarette smoke treated cells by virtue of the present invention. Because cigarette smoke is considered to be a major causative factor of chronic obstructive pulmonary disease (COPD) and disorders and conditions related thereto, the RAI-3 protein is newly provided as a cellular drug target for screening, discovering, and identifying modulators for the treatment and/or prevention of COPD and its related disorders and conditions, such as emphysema and chronic bronchitis. In accordance with the present invention RAI-3 modulators, e.g., agonists and antagonists, can be used as therapeutics in the treatment of COPD and numerous other diseases and disorders that are associated with regulation of NF-κB and/or its associated or interacting signaling molecules. This invention further provides SNPs of RAI-3, e.g., for determining COPD association in individuals.
摘要翻译： 本发明描述了在将烟草暴露于烟草燃烧物质（即香烟烟雾）之后，新鉴定为被修饰，例如磷酸化并与酪氨酸磷酸化活化复合物相关的G-蛋白偶联受体（GPCR）家族成员。 该GPCR蛋白是RAI-3，其首先被发现在用香烟烟雾处理的细胞中被磷酸化并且与通过本发明在香烟烟雾处理的细胞中活化的其它蛋白质相关联。 由于香烟烟雾被认为是慢性阻塞性肺疾病（COPD）的主要致病因素及与之相关的病症和病症，所以RAI-3蛋白质作为筛选，发现和鉴定调节剂治疗的细胞药物靶点被新提供 和/或预防COPD及其相关疾病和病症如肺气肿和慢性支气管炎。 根据本发明，RAI-3调节剂（例如激动剂和拮抗剂）可用作治疗COPD和许多与调节NF-κB和/或其相关或相互作用的信号相关的其它疾病和病症 分子。 本发明还提供RAI-3的SNP，例如用于确定个体中的COPD关联。
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公开(公告)号：US20050130286A1
公开(公告)日：2005-06-16
申请号：US10029345
申请日：2001-12-20
申请人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
发明人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
IPC分类号： A61K38/00 , A61K38/43 , A61K48/00 , A61P1/16 , A61P11/00 , A61P13/12 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12N15/55 , C12P21/00 , C12Q1/02 , C12Q1/68 , G01N33/573 , G01N33/68 , G06F19/16 , C07H21/04
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20060014180A1
公开(公告)日：2006-01-19
申请号：US11143984
申请日：2005-06-02
申请人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
发明人： Donald Jackson , Chandra Ramanathan , John Feder , Gabe Mintier , Liana Lee , Thomas Nelson , Nathan Siemers , David Bol , Suzanne Suchard , Gary Schieven , Joshua Finger , C. Todderrud , Donna Bassolino , Stanley Krystek , Dana Banas , Patrick McAtee
CPC分类号： G06F19/16 , A61K38/00 , C07K2319/00 , C07K2319/30 , C12N9/16 , C12Q1/6883 , C12Q2600/158 , C12Y301/03048 , G01N33/573 , G01N33/6893 , G01N2333/916 , G01N2500/00 , G01N2500/04 , Y02A90/26
摘要： The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人磷酸酶多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型人磷酸酶多肽应用于诊断，治疗和/或预防与这些多肽，特别是心血管疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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6.发明申请POLYNUCLEOTIDES ENCODING A NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR SPLICE VARIANT, HGPRBMY29SV2 有权编码新型人G蛋白偶联受体SPLICE变体的多核苷酸，HGPRBMY29SV2公开(公告)号：US20070196897A1
公开(公告)日：2007-08-23
申请号：US11071761
申请日：2005-03-03
申请人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
发明人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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7.发明申请Polynucleotides encoding two novel human G-protein coupled receptors, HGPRBMY28 and HGPRBMY29, and splice variants thereof 有权编码两种新型人G蛋白偶联受体的多核苷酸HGPRBMY28和HGPRBMY29及其剪接变体公开(公告)号：US20080064094A1
公开(公告)日：2008-03-13
申请号：US11890963
申请日：2007-08-08
申请人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
发明人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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8.发明申请Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1 有权人类含有亮氨酸的重复含有蛋白质主要在骨髓HLRRBM1中表达公开(公告)号：US20050203048A1
公开(公告)日：2005-09-15
申请号：US11107572
申请日：2005-04-15
申请人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
发明人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C12Q1/68 , A61K48/00 , C07H21/04 , C07K14/82 , G01N33/574
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/53 , C07K14/47
摘要： The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRBM1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly immune diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HLRRBM1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRBM1多肽应用于诊断，治疗和/或预防与这些多肽，特别是免疫疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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9.发明申请公开(公告)号：US20050148016A1
公开(公告)日：2005-07-07
申请号：US11070456
申请日：2005-03-02
申请人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
发明人： John Feder , Chandra Ramanathan , Gabriel Mintier , David Bol , Donald Hawken
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/68 , C07H21/04 , C07K16/28
CPC分类号： A61K49/0008 , A61K38/00 , C07K14/705 , C07K16/2863 , C07K2317/21 , C07K2317/622 , Y10S435/975
摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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10.发明申请公开(公告)号：US20060292625A1
公开(公告)日：2006-12-28
申请号：US11511141
申请日：2006-08-28
申请人： John Feder , Chandra Ramanathan , Gabriel Mintier
发明人： John Feder , Chandra Ramanathan , Gabriel Mintier
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly nervous system diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HLLRCR-1多肽的新型多核苷酸，其片段和同源物。还提供了用于产生所述多肽的载体，宿主细胞，抗体以及重组和合成方法。 本发明还涉及将这些新型HLLRCR-1多肽应用于诊断，治疗和/或预防与这些多肽，特别是神经系统疾病和/或病症相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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