公开(公告)号：US20130066309A1

公开(公告)日：2013-03-14

申请号：US13471826

申请日：2012-05-15

申请人： Mitchell E. Levinson

发明人： Mitchell E. Levinson

IPC分类号： A61B18/02 ,  A61B18/04

CPC分类号： A61H1/008 ,  A61B18/14 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00047 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61F7/007 ,  A61F7/02 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/0075 ,  A61F2007/029

摘要： Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

公开(公告)号：US06575940B1

公开(公告)日：2003-06-10

申请号：US09315702

申请日：1999-05-20

申请人： Mitchell E. Levinson ,  Gordon Howard Epstein

发明人： Mitchell E. Levinson ,  Gordon Howard Epstein

IPC分类号： A61M500

CPC分类号： A61B17/00491 ,  A61B2017/00495

摘要： A sealant applicator suitable for dispensing a coagulable sealant, for example a two-component fibrin sealant mixed in the applicator, employs impulse clearing to remove residual coagulated or coagulating material from the dispensing pathway and mixing chamber, if present. Impulses may be generated by manual application of a clearing member such as a plunger which can enter into the dispensing pathway to engage, dislodge and discharge residuals or can generate a gas impulse to impact the residuals to similar effect. A clearing valve having a clearing port can be operated by movement of the clearing member to provide access to the dispensing pathway.

摘要翻译： 适用于分配可凝结密封剂的密封剂施加剂，例如混合在施用器中的双组分纤维蛋白密封剂，采用冲洗清除，以从分配通道和混合室（如果存在）中除去残留的凝固或凝结材料。 可以通过手动施加诸如柱塞的清理构件来产生冲击，所述柱塞可以进入分配路径以接合，移除和排出残余物，或者可以产生气体冲击以冲击残余物以产生类似的效果。 具有清除口的清除阀可以通过清除构件的移动来操作，以提供对分配通路的通路。

公开(公告)号：US06921380B1

公开(公告)日：2005-07-26

申请号：US09408091

申请日：1999-09-29

申请人： Gordon Howard Epstein ,  Mitchell E. Levinson

发明人： Gordon Howard Epstein ,  Mitchell E. Levinson

IPC分类号： A61M37/00 ,  A61M5/00 ,  B67D5/52

CPC分类号： A61M37/00 ,  A61M2202/0425 ,  A61M2202/0449

摘要： A multi-component sealant applicator comprises a dual catheter for delivering sealant. Each catheter communicates with one of a pair of fluid sealant agent sources and comprises a mixing volume within the dual catheter for mixing multiple components of a multi-component sealant prior to discharge from a distal end of the catheter and a clearing system to clear undesired material from the mixing volume or the vicinity of the mixing volume, wherein one catheter is mounted for longitudinal movement within the other and the inner catheter is usable as a plunger to remove clogs. The catheter may comprise a reciprocal drive mechanism proximally coupled with the dual catheter to move one catheter longitudinally with respect to the other. The drive mechanism may comprise a ratchet and pawl.

摘要翻译： 多组分密封剂涂布器包括用于输送密封剂的双重导管。 每个导管与一对流体密封剂源中的一个连通，并且包括双重导管内的混合体积，用于在从导管的远端排出之前混合多部件密封剂的多个部件，并且清除系统以清除不需要的材料 从混合体积或混合体积附近，其中一个导管安装成在另一个内部纵向移动，并且内导管可用作柱塞以除去堵塞物。 导管可以包括与双导管近端耦合的往复驱动机构，以相对于另一个纵向移动一根导管。 驱动机构可以包括棘轮和棘爪。

公开(公告)号：US20070255362A1

公开(公告)日：2007-11-01

申请号：US11741271

申请日：2007-04-27

申请人： Mitchell E. Levinson ,  Donald Johnson ,  Jessica Preciado ,  Edward A. Ebbers ,  Daniel Bucks

发明人： Mitchell E. Levinson ,  Donald Johnson ,  Jessica Preciado ,  Edward A. Ebbers ,  Daniel Bucks

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/00 ,  A61B90/04 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0075 ,  A61F2007/029

摘要： A cryoprotectant for use with a treatment device for improved removal of heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cryoprotectant is a non-freezing liquid, gel, or paste for allowing pre-cooling of the treatment device below 0° C. while preventing the formation of ice thereon. The cryoprotectant may also prevent freezing of the treatment device to the skin or ice from forming from moisture seeping out from the skin. The cryoprotectant may further be hygroscopic, thermally conductive, and biocompatible.

摘要翻译： 提供了一种用于治疗装置的冷冻保护剂，用于从具有皮肤的受试者的皮下富含脂质的细胞中改善对热的去除。 冷冻保护剂是一种非冻结液体，凝胶或糊剂，用于允许将处理装置预冷却至低于0℃，同时防止其上形成冰​​。 冷冻保护剂还可以防止治疗装置冻结到皮肤或冰层，从而从皮肤渗出的湿气中形成。 冷冻保护剂可以进一步具有吸湿性，导热性和生物相容性。

公开(公告)号：US06488650B1

公开(公告)日：2002-12-03

申请号：US09456728

申请日：1999-12-08

申请人： Gordon Howard Epstein ,  Mitchell E. Levinson ,  Richard Spero ,  Adam Hagmann

发明人： Gordon Howard Epstein ,  Mitchell E. Levinson ,  Richard Spero ,  Adam Hagmann

IPC分类号： A61M3700

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2058 ,  A61J1/2096 ,  A61M5/1782

摘要： A filling device and method, particularly for two-component sealants such as fibrin sealants, which enables two fluids to be separately and directly filled to the reservoirs of a dual syringe fluid applicator from two storage containers, which can be standardized, sealed, sterilized bottles. The device has a connector which engages with the fluid applicator, is keyed to orient the applicator's fluid reservoirs in a predetermined manner and holds the containers in side-by-side alignment with the applicator. Two fluid conduits whose downward ends may be pointed to pierce seals on the bottles, extend between the applicator and the bottles and can each have a transverse reach to accommodate the girth of the bottles. The bottles may be tilted by the device to enable the conduits to draw maximal fluid from a lowermost point of the bottle. Tilting can be effected by a downward movement of the device supporting the applicator which movement can introduce the fluid conduits into the bottles. A shroud can enclose and seal the bottles and permit the apparatus complete with fluid applicator to be introduced into a sterile environment. Additionally embodiments for use with a single vial are also disclosed.

摘要翻译： 一种填充装置和方法，特别是用于诸如纤维蛋白密封剂的双组分密封剂，其使得两个流体能够从两个储存容器分开并直接填充到双注射器流体给药器的储存器中，这两个储存容器可以是标准化的密封灭菌瓶 。 该装置具有与流体施用器接合的连接器，用于以预定的方式定位施用器的流体储存器，并且将容器与施加器并排地对准。 两个流体管道，其下端可以指向刺穿瓶子上的密封件，在施用器和瓶子之间延伸，并且每个可以具有横向到达以适应瓶子的周长。 瓶子可以被装置倾斜，以使管道从瓶的最低点吸取最大流体。 倾斜可以通过支撑施加器的装置的向下运动来实现，该运动可以将流体导管引入瓶中。 护罩可以封闭并密封瓶子，并允许将流体施用器完成的装置引入无菌环境中。 还公开了与单个小瓶一起使用的另外的实施例。

公开(公告)号：US06475183B1

公开(公告)日：2002-11-05

申请号：US09307056

申请日：1999-05-07

申请人： Gordon Howard Epstein ,  Mitchell E. Levinson ,  Richard Spero

发明人： Gordon Howard Epstein ,  Mitchell E. Levinson ,  Richard Spero

IPC分类号： A61M3700

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2058 ,  A61J1/2096 ,  A61M5/1782

摘要： A filling device for connecting a dispensing instrument having multiple fluid reservoirs to multiple containers is disclosed. More particularly, the present invention discloses a connecting device capable of coupling the individual reservoirs of a dispensing instrument to multiple fluid containers. The apparatus includes a body, a collar extending from the body, a plurality of tubes in fluid communication with a plurality of inlet ports formed in the body, and a hood adapted to simultaneously receive a plurality of containers therein. The containers are positioned within the hood to allow the plurality of tubes to simultaneously and separately draw fluid from the fluid containers and transferring the material into the individual reservoirs of the dispensing instrument.

摘要翻译： 公开了一种用于将具有多个流体储存器的分配装置连接到多个容器的填充装置。 更具体地，本发明公开了一种连接装置，其能够将分配仪器的各储存器连接到多个流体容器。 该装置包括主体，从主体延伸的轴环，与形成在主体中的多个入口端口流体连通的多个管，以及适于同时在其中容纳多个容器的罩。 容器位于罩内，以允许多个管同时并分别从流体容器中抽出流体并将材料转移到分配器具的各个储存器中。

公开(公告)号：US09408745B2

公开(公告)日：2016-08-09

申请号：US13616391

申请日：2012-09-14

申请人： Mitchell E. Levinson ,  Jesse Nicasio Rosen ,  Corydon A. Hinton ,  Kevin S. Springer

发明人： Mitchell E. Levinson ,  Jesse Nicasio Rosen ,  Corydon A. Hinton ,  Kevin S. Springer

IPC分类号： A61F7/00 ,  A61F7/02 ,  A61F7/10 ,  A61B17/00 ,  A61H9/00 ,  A61H23/02

CPC分类号： A61F7/10 ,  A61B2017/00084 ,  A61F7/007 ,  A61F7/02 ,  A61F2007/0001 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0096 ,  A61F2007/0228 ,  A61F2007/0239 ,  A61F2007/029 ,  A61H9/0057 ,  A61H23/0263 ,  A61H2201/0214 ,  A61H2201/0285 ,  A61H2201/10 ,  A61H2201/501 ,  A61H2230/50

摘要： A system and method of monitoring, controlling and/or detecting events during the removal of heat from subcutaneous lipid-rich tissue is described. In some examples, the system detects an increase in temperature at a treatment device in contact with the skin of a subject, determines that the increase in temperature is related to a treatment event, and performs an action based on the determination. In some examples, the system shuts off the treatment device, alerts an operator, or reduces the cooling in response to a determined treatment event.

摘要翻译： 描述了在从皮下富含脂质组织去除热量期间监测，控制和/或检测事件的系统和方法。 在一些示例中，系统检测与受试者皮肤接触的治疗装置处的温度升高，确定温度的升高与治疗事件相关，并且基于该确定执行动作。 在一些示例中，系统关闭治疗装置，警告操作者或响应于确定的治疗事件减少冷却。

公开(公告)号：US08676338B2

公开(公告)日：2014-03-18

申请号：US12840235

申请日：2010-07-20

申请人： Mitchell E. Levinson

发明人： Mitchell E. Levinson

IPC分类号： A61F7/00

CPC分类号： A61B18/14 ,  A61B18/02 ,  A61B2018/00023 ,  A61B2018/00464 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2090/065

摘要： Systems and methods that enable delivery of radiofrequency energy and cryotherapy applications to adipose tissue for reduction and contouring of body fat are described herein. Aspects of the disclosure are directed to methods for reducing surface irregularities in a surface of a subject's skin resulting from an uneven distribution of adipose tissue in the subcutaneous layer. The method can include delivering capacitively coupled or conductively coupled radiofrequency energy to a target region of the subject at a frequency which selectively heats fibrous septae in a subcutaneous layer of the target region to a maximum temperature less than a fibrous septae denaturation temperature. Furthermore, the method can include removing heat such that lipid-rich lobules in the subcutaneous layer are affected while non-lipid-rich cells and lipid-rich regions adjacent to the fibrous septae are not substantially affected.

摘要翻译： 这里描述了能够将射频能量和冷冻治疗应用传递到脂肪组织以用于身体脂肪的减少和轮廓的系统和方法。 本公开的方面涉及减少由皮下层中的脂肪组织不均匀分布导致的受试者皮肤表面的表面不规则性的方法。 该方法可以包括以选择性地将目标区域的皮下层中的纤维隔膜加热至低于纤维性隔膜变性温度的最高温度的频率，将电容耦合或导电耦合的射频能量递送到受试者的目标区域。 此外，该方法可以包括去除热量，使得皮下层中富含脂质的小叶受到影响，而与富含纤维的隔膜相邻的富含脂质的细胞和富含脂质的区域基本上不受影响。

公开(公告)号：US20120022518A1

公开(公告)日：2012-01-26

申请号：US12840235

申请日：2010-07-20

申请人： Mitchell E. Levinson

发明人： Mitchell E. Levinson

IPC分类号： A61B18/18

CPC分类号： A61B18/14 ,  A61B18/02 ,  A61B2018/00023 ,  A61B2018/00464 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2090/065

摘要： Systems and methods that enable delivery of radiofrequency energy and cryotherapy applications to adipose tissue for reduction and contouring of body fat are described herein. Aspects of the disclosure are directed to methods for reducing surface irregularities in a surface of a subject's skin resulting from an uneven distribution of adipose tissue in the subcutaneous layer. The method can include delivering capacitively coupled or conductively coupled radiofrequency energy to a target region of the subject at a frequency which selectively heats fibrous septae in a subcutaneous layer of the target region to a maximum temperature less than a fibrous septae denaturation temperature. Furthermore, the method can include removing heat such that lipid-rich lobules in the subcutaneous layer are affected while non-lipid-rich cells and lipid-rich regions adjacent to the fibrous septae are not substantially affected.

摘要翻译： 这里描述了能够将射频能量和冷冻治疗应用传递到脂肪组织以用于身体脂肪的减少和轮廓的系统和方法。 本公开的方面涉及减少由皮下层中的脂肪组织不均匀分布导致的受试者皮肤表面的表面不规则性的方法。 该方法可以包括以选择性地将目标区域的皮下层中的纤维隔膜加热至低于纤维性隔膜变性温度的最高温度的频率，将电容耦合或导电耦合的射频能量递送到受试者的目标区域。 此外，该方法可以包括去除热量，使得皮下层中富含脂质的小叶受到影响，而与富含纤维的隔膜相邻的富含脂质的细胞和富含脂质的区域基本上不受影响。

公开(公告)号：US20080077202A1

公开(公告)日：2008-03-27

申请号：US11558046

申请日：2006-11-09

申请人： Mitchell E. Levinson

发明人： Mitchell E. Levinson

IPC分类号： A61F7/00 ,  A61F2/00 ,  A61F7/12

CPC分类号： A61H1/008 ,  A61B18/14 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00047 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61F7/007 ,  A61F7/02 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/0075 ,  A61F2007/029

摘要： Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

摘要翻译： 本文提供了影响受试者身体区域的方法，包括在有效地冷却所述区域中的皮下脂肪组织的条件下将该区域暴露于冷却元件; 以及通过将组织暴露于能量来增加到冷却的组织的血液流速。 还提供了用于治疗受试者身体区域中的皮下脂肪组织的方法，包括在有效冷却所述组织的条件下将所述区域暴露于冷却元件; 并将组织暴露于能量源以增加到冷却的组织的血液流速，从而刺激冷却的组织的再灌注和/或引起缺血再灌注损伤。