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    System and method for regulating cardiac triggered therapy to the brain
    25.
    发明授权
    System and method for regulating cardiac triggered therapy to the brain 有权

    公开(公告)号：US07949391B2

    公开(公告)日：2011-05-24

    申请号：US11311200

    申请日：2005-12-19

    申请人： Jonathon E. Giftakis ,  Nina M. Graves

    发明人： Jonathon E. Giftakis ,  Nina M. Graves

    IPC分类号： A61B5/00

    摘要： A medical device system includes a brain monitoring element, cardiac monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiac event in the cardiac signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiac triggered therapeutic output to the brain based upon the brain monitoring. A method of treating a person with a neurological disorder is also provided.

    Clustering of recorded patient neurological activity to determine length of a neurological event
    27.
    发明授权
    Clustering of recorded patient neurological activity to determine length of a neurological event 有权
    记录患者神经活动的聚类，以确定神经系统事件的长度

    公开(公告)号：US07933646B2

    公开(公告)日：2011-04-26

    申请号：US11837987

    申请日：2007-08-13

    申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC分类号： A61B5/04

    CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

    摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

    Clustering of recorded patient neurological activity to determine length of a neurological event
    30.
    发明授权
    Clustering of recorded patient neurological activity to determine length of a neurological event 有权
    记录患者神经活动的聚类，以确定神经系统事件的长度

    公开(公告)号：US07280867B2

    公开(公告)日：2007-10-09

    申请号：US10687571

    申请日：2003-10-15

    申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04012 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/7217 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  Y10S128/92

    摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。