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31 条记录 (耗时 0.036 秒)

    DNA molecules encoding human chordin
    26.
    发明授权
    DNA molecules encoding human chordin 失效
    编码人类chordin的DNA分子

    公开(公告)号：US5846770A

    公开(公告)日：1998-12-08

    申请号：US749169

    申请日：1996-11-14

    申请人： Edward R. LaVallie ,  Lisa A. Racie ,  Edward M. DeRobertis

    发明人： Edward R. LaVallie ,  Lisa A. Racie ,  Edward M. DeRobertis

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12 ,  C12N15/18 ,  C12P21/00 ,  C07H21/04 ,  C12N1/21 ,  C12N15/00

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/00

    摘要： Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.

    摘要翻译： 公开了纯化的chordin蛋白质及其生产方法。 还公开了编码chordin蛋白的DNA分子。 蛋白质可以用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮的组织的病症和缺陷， 神经，肌肉，包括心肌和其他组织和伤口，以及诸如肝，脑，肺，心脏，胰腺和肾组织的器官。 蛋白质也可用于诱导抑制未分化的胚胎和干细胞的生长和/或分化。 蛋白质可能与其他蛋白质，特别是蛋白质转化生长因子-β超家族的成员复合。

    Chordin compositions
    28.
    发明授权
    Chordin compositions 有权
    Chordin组成

    公开(公告)号：US5986056A

    公开(公告)日：1999-11-16

    申请号：US130032

    申请日：1998-08-04

    申请人： Edward R. LaVallie ,  Lisa A. Racie ,  Edward M. DeRobertis

    发明人： Edward R. LaVallie ,  Lisa A. Racie ,  Edward M. DeRobertis

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12 ,  C12N15/18 ,  C07K14/46 ,  C12P21/00

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/00

    摘要： Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well for treatment of disorders and defects to tissue which include epidermis, nerve, muscle, including cardiac muscle, and othe tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.

    摘要翻译： 公开了纯化的chordin蛋白质及其生产方法。 还公开了编码chordin蛋白的DNA分子。 这些蛋白质可用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮，神经的组织的病症和缺陷 ，肌肉，包括心肌，组织和伤口，器官如肝，脑，肺，心脏，胰腺和肾组织。 蛋白质也可用于诱导抑制未分化的胚胎和干细胞的生长和/或分化。 蛋白质可能与其他蛋白质，特别是蛋白质转化生长因子-β超家族的成员复合。

    Human SDF-5 protein and compositions
    29.
    发明授权
    Human SDF-5 protein and compositions 失效
    人类SDF-5蛋白和组成

    公开(公告)号：US07026445B2

    公开(公告)日：2006-04-11

    申请号：US08949904

    申请日：1997-10-15

    申请人： Edward R. LaVallie ,  Lisa A. Racie ,  Gary Hattersley

    发明人： Edward R. LaVallie ,  Lisa A. Racie ,  Gary Hattersley

    IPC分类号： C07K1/00 ,  C07H21/02 ,  C12P27/06 ,  C12N1/20

    CPC分类号： C07K14/52 ,  A61K38/00

    摘要： Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.

    摘要翻译： 公开了纯化的人SDF-5蛋白质及其生产方法。 还公开了编码人SDF-5蛋白的DNA分子。 蛋白质可用于调节Wnt基因与其受体的结合。 在优选的实施方案中，蛋白质可用于诱导软骨细胞和/或软骨组织的形成，生长，分化，增殖和/或维持，以及用于其它组织修复，例如胰腺组织修复。

    Aggrecanase molecules
    30.
    发明授权
    Aggrecanase molecules 失效

    公开(公告)号：US07125701B2

    公开(公告)日：2006-10-24

    申请号：US10205368

    申请日：2002-07-26

    申请人： Michael J. Agostino ,  Lisa A. Racie

    发明人： Michael J. Agostino ,  Lisa A. Racie

    IPC分类号： C12N9/48 ,  C12Q1/37

    CPC分类号： C12N9/6421

    摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.