公开(公告)号：US06509482B2

公开(公告)日：2003-01-21

申请号：US09978690

申请日：2001-10-18

申请人： Koji Kawamura ,  Masahiro Ueno ,  Masashi Suzuki ,  Makoto Yanai ,  Toshihiro Takahashi ,  Koichi Itoh

发明人： Koji Kawamura ,  Masahiro Ueno ,  Masashi Suzuki ,  Makoto Yanai ,  Toshihiro Takahashi ,  Koichi Itoh

IPC分类号： C07D31914

CPC分类号： C07D319/20 ,  C12P17/06 ,  C12P41/004

摘要： Disclosed are optically active alcohols having formulae (1) and (2) wherein R is (R)-1-phenylethylamino or (S)-1-phenylethylamino.

摘要翻译： 公开了具有式（1）和（2）的光学活性醇，其中R是（R）-1-苯乙基氨基或（S）-1-苯乙基氨基。

公开(公告)号：US06316406B1

公开(公告)日：2001-11-13

申请号：US09379614

申请日：1999-08-24

申请人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

发明人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

IPC分类号： A61K3815

CPC分类号： C07K7/06 ,  A61K38/00

摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): (wherein R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is a group of the formula —A—B—W—(D)m—(E)n, —A—B—W—(D)m—(E)n—F or —A—B—W—(D)m—(E)n—F—Z; R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula —Z, —Z—G or —Z—G—J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.

摘要翻译： 含有具有式（1）或（2）的N-取代甘氨酸残基的缩酚酸肽:(其中R 1是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; R2 是式-ABW-（D）m-（E）n，-ABW-（D）m-（E）nF或-ABW-（D）m-（E）nFZ的基团; R3是羟基 ，低级烷氧基，苄氧基或式-Z，-ZG或-ZGJ的基团; A，B，D，E，F，G和J独立地为N-取代的甘氨酸残基或 选自丙氨酸，缬氨酸，亮氨酸，丝氨酸等的氨基酸; W和Z独立地是选自天冬氨酸，谷氨酸等的氨基酸的残基;至少 A，B，D，E，F，G和J之一是N-取代的甘氨酸残基）或其药理学上可接受的盐。 上述脱脂肽对载脂蛋白E的产生具有促进作用，可用作神经损伤的治疗剂，特别是痴呆和高脂血症。

公开(公告)号：US6008891A

公开(公告)日：1999-12-28

申请号：US969550

申请日：1997-11-13

申请人： Hiroto Kobayashi ,  Yoshitomo Tamura ,  Koji Kawamura ,  Minoru Nakakusu

发明人： Hiroto Kobayashi ,  Yoshitomo Tamura ,  Koji Kawamura ,  Minoru Nakakusu

IPC分类号： G01N27/90 ,  B24B27/033 ,  B24B49/10 ,  B24B49/12 ,  G01N27/82 ,  G01N21/01

CPC分类号： B24B27/033 ,  G01N27/82

摘要： An automatic flaw removing method for long materials, comprises the steps of: inspecting long materials, such as round-bar steels and steel pipes, for surface flaws by a flaw inspecting apparatus of all section to divide the long materials into rejected materials having a flaw(s) and accepted materials having no flaw; storing information on the longitudinal position and length of each of the flaws of the rejected materials in a storage unit; sequentially carrying out the tracking of each of the rejected materials; moving a circumferential flaw probe directly connected to a grinder, to a longitudinal coordinate position of each of the flaws of the rejected materials, on the basis of the information on the longitudinal position of each of the flaws stored in the storage unit, when each of the rejected materials arrives at a flaw grinding position; rotating each of the rejected materials; identifying a circumferential position of each of the flaws by picking up a flaw indicative signal by the circumferential flaw probe; and automatically grinding each of the rejected materials, on the basis of the information on the identified circumferential position of each of the flaws and the information on the longitudinal position and length of each of the flaws stored in the storage unit. Thus, it is possible to interlock a high-speed automatic flaw inspecting apparatus with an automatic grinder to automatically remove surface flaws of long materials.

摘要翻译： 用于长材料的自动缺陷方法包括以下步骤：通过所有部分的缺陷检查装置检查诸如圆棒钢和钢管的长材料的表面缺陷，以将长材料分成具有缺陷的拒绝材料 （s）和接受的没有缺陷的材料; 将关于被拒绝材料的每个缺陷的纵向位置和长度的信息存储在存储单元中; 依次执行每个拒收材料的跟踪; 根据关于存储在存储单元中的每个缺陷的纵向位置的信息，将直接连接到研磨机的圆周缺陷探针移动到被拒绝材料的每个缺陷的纵向坐标位置 被拒绝的材料到达缺陷磨削位置; 旋转每个被拒绝的材料; 通过周向缺陷探针拾取缺陷指示信号来识别每个缺陷的圆周位置; 并基于所识别的每个缺陷的圆周位置的信息和关于存储在存储单元中的每个缺陷的纵向位置和长度的信息自动研磨每个被拒绝的材料。 因此，可以将高速自动探伤装置与自动研磨机互锁，以自动消除长材料的表面缺陷。

公开(公告)号：US6001815A

公开(公告)日：1999-12-14

申请号：US218125

申请日：1998-12-21

申请人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

发明人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

IPC分类号： A61K38/00 ,  C07K7/06

CPC分类号： C07K7/06 ,  A61K38/00

摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): ##STR1## (wherein R.sub.1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R.sub.2 is a group of the formula --A--B--W--(D).sub.m --(E).sub.n, --A--B--W--(D).sub.m --(E).sub.n --F or --A--B--W--(D).sub.m --(E).sub.n --F--Z; R.sub.3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula --Z, --Z--G or --Z--G--J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof.The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.

摘要翻译： 含有具有式（1）或（2）的N-取代甘氨酸残基的depsipeptide：（其中R1是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; R2 是式-ABW-（D）m-（E）n，-ABW-（D）m-（E）nF或-ABW-（D）m-（E）nFZ的基团; R3是羟基 ，低级烷氧基，苄氧基或式-Z，-ZG或-ZGJ的基团; A，B，D，E，F，G和J独立地为N-取代的甘氨酸残基或 选自丙氨酸，缬氨酸，亮氨酸，丝氨酸等的氨基酸; W和Z独立地是选自天冬氨酸，谷氨酸等的氨基酸的残基;至少 A，B，D，E，F，G和J之一是N-取代的甘氨酸残基）或其药理学上可接受的盐。 上述脱脂肽对载脂蛋白E的产生具有促进作用，可用作神经损伤的治疗剂，特别是痴呆和高脂血症。

公开(公告)号：US07375115B2

公开(公告)日：2008-05-20

申请号：US10492065

申请日：2002-10-08

申请人： Ryuuta Fukutomi ,  Hitoshi Inoue ,  Koji Kawamura ,  Takuya Kishimoto ,  Masashi Suzuki ,  Rie Shibayama ,  Kazuko Kojima ,  Kouichirou Hagihara

发明人： Ryuuta Fukutomi ,  Hitoshi Inoue ,  Koji Kawamura ,  Takuya Kishimoto ,  Masashi Suzuki ,  Rie Shibayama ,  Kazuko Kojima ,  Kouichirou Hagihara

IPC分类号： A01N43/40 ,  C07D401/00

CPC分类号： C07D401/12 ,  C07D211/58 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14

摘要： There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxy-carbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

摘要翻译： 提供由通式（I）表示的新型4（2-糠酰基）氨基哌啶，其合成中间体，其制备方法和含有它们的药物。 在上式中，X为OH或N，Y为下列通式（II），式（II-a）或式（III）的基团：其中a，b和c各自为0〜 6; Z是CH 2或NH; W为O或S; T是O或N-R 15，其中R 15是H，C 1 -C 6烷基，苄基或苯乙基; R 1是H，C 1 -C 6烷氧基羰基，苄氧基羰基等。 根据本发明的4-（2-糠酰基）氨基哌啶衍生物具有阿片样物质μ拮抗活性，可用于治疗或预防由mu受体激动剂引起的副作用，其选自便秘，恶心/呕吐或瘙痒， 或用于治疗或预防特发性便秘，术后肠梗阻，麻痹性肠梗阻，肠易激综合征或慢性瘙痒。

公开(公告)号：US20060018793A1

公开(公告)日：2006-01-26

申请号：US10512431

申请日：2003-03-26

申请人： Tomohiko Hashiba ,  Koji Kawamura

发明人： Tomohiko Hashiba ,  Koji Kawamura

IPC分类号： G01N33/00

CPC分类号： G01N31/22 ,  G01N21/783 ,  G01N31/223 ,  Y10T436/202499

摘要： A method of speedily measuring the formaldehyde concentration of test gas with high sensitivity without suffering influences of coexisting gases; and a measuring instrument therefore. In particular, a method of measuring the formaldehyde concentration characterized in that a test gas is brought into contact with a filter wetted with a color forming agent consisting of an alkali aqueous solution of 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (AHMT) so as to induce color formation, and that the formaldehyde concentration of test gas is determined on the basis of the degree of color formation; and a measuring instrument including a light emitting element (LED) , a light receiving element (PIN type photodiode) and a display arranged so as to optically measure the degree of color formation.

摘要翻译： 一种快速测定试验气体甲醛浓度的方法，高灵敏度，不受共存气体的影响; 和测量仪器。 特别是测定甲醛浓度的方法，其特征在于使试验气体与用由4-氨基-3-肼基-5-巯基-1的碱性水溶液组成的显色剂润湿的过滤器接触， 2,4-triazole（AHMT），以诱导颜色形成，并且测试气体的甲醛浓度是根据颜色形成程度确定的; 以及包括发光元件（LED），光接收元件（PIN型光电二极管）和布置以光学地测量颜色形成的显示器的测量仪器。

公开(公告)号：US06503069B2

公开(公告)日：2003-01-07

申请号：US09964314

申请日：2001-09-26

申请人： Takahiro Moroi ,  Ryuta Kawaguchi ,  Tsutomu Nasuda ,  Koji Kawamura ,  Masato Sowa ,  Tatsuyuki Hoshino ,  Yoshiyuki Nakane ,  Hidehito Kubo ,  Hirohisa Katoh ,  Daisuke Satoh

发明人： Takahiro Moroi ,  Ryuta Kawaguchi ,  Tsutomu Nasuda ,  Koji Kawamura ,  Masato Sowa ,  Tatsuyuki Hoshino ,  Yoshiyuki Nakane ,  Hidehito Kubo ,  Hirohisa Katoh ,  Daisuke Satoh

IPC分类号： F01C102

CPC分类号： F04C29/04 ,  F04C18/0215 ,  F04C23/008 ,  F04C29/045

摘要： The scroll-type compressor with an integrated motor of the present invention comprises a housing 1, a fixed scroll 21 fixed to the housing 1, a movable scroll 31 installed eccentrically to the fixed scroll 21, and a motor portion 5, and is characterized in that the housing 1 comprises a high pressure chamber 25 to which compressed gases are supplied, a first cooling chamber 26′ installed contiguous to the high pressure chamber 25 and to which cooling fluid is supplied, a second cooling chamber 42 which cools the motor portion 5 and is supplied with the cooling fluid, and a fluid passage 7 that connects the first cooling chamber 26′ and the second cooling chamber 42 and passes the cooling fluid in the direction from the first cooling chamber 26′ to the second cooling chamber 42.

公开(公告)号：US06288038B1

公开(公告)日：2001-09-11

申请号：US09509132

申请日：2000-04-03

申请人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

发明人： Makoto Yanai ,  Masashi Suzuki ,  Norio Oshida ,  Koji Kawamura ,  Shigeru Hiramoto ,  Orie Yasuda ,  Nobuhiro Kinoshita ,  Akiko Shingai ,  Masako Takasu

IPC分类号： A61K3150

CPC分类号： C07K5/06139 ,  A61K38/00 ,  C07K5/0207

摘要： The present invention provides a new depsipeptide derivative having a piperazinone ring within the molecule which is represented by formula (1) wherein X1 represents N(R4)—CO, N(R5)—CH2, CH2—CO, CH2—CH2, CH═CH, CH2—CH(OH) or CH(OH)—CH(OH), R1 represents a C5-C20 alkyl group or a C5-C15 alkoxy C1-C4 alkyl group, R2-R5 represent a hydrogen atom or a C1-C6 alkyl group, and A represents a group of formula (2), (3) or (4) The depsipeptide derivative has a function of accelerating the production of apolipoprotein E and is useful as an agent for the treatment of neurologic injury, an agent for the treatment of dementia and an antihyperlipidemic agent.

摘要翻译： 本发明提供了在分子内具有哌嗪酮环的新的脱脂肽衍生物，其由式（1）表示，其中X 1表示N（R 4）-CO，N（R 5）-CH 2，CH 2 -CO，CH 2 -CH 2，CH = CH ，CH 2 -CH（OH）或CH（OH）-CH（OH），R 1表示C 5 -C 20烷基或C 5 -C 15烷氧基C 1 -C 4烷基，R 2 -R 5表示氢原子或C 1 -C 6 烷基，A表示式（2），（3）或（4）的基团。三肽衍生物具有加速载脂蛋白E的产生的功能，可用作治疗神经损伤的药剂， 治疗痴呆症和抗高血脂药物。

公开(公告)号：US06227812B1

公开(公告)日：2001-05-08

申请号：US09041583

申请日：1998-03-12

申请人： Masahiro Kawaguchi ,  Yoshihiro Makino ,  Masanori Sonobe ,  Koji Kawamura

发明人： Masahiro Kawaguchi ,  Yoshihiro Makino ,  Masanori Sonobe ,  Koji Kawamura

IPC分类号： F04B126

CPC分类号： F04B27/1804 ,  F04B49/225 ,  F04B2027/1827 ,  F04B2027/1854 ,  F04B2027/1859 ,  F04B2201/1241 ,  F04B2207/03 ,  F25B1/02

摘要： A refrigerant circuit includes a compressor and an expansion valve. The expansion valve is connected to a discharge muffler of the compressor by a high pressure conduit. The expansion valve is also connected to a suction passage of the compressor by a low pressure conduit. The high pressure conduit includes a condenser and the low pressure conduit includes an evaporator. A check valve is located between the discharge muffler and the high pressure conduit to selectively connect and disconnect the high pressure conduit with the discharge muffler. A relief valve is attached to the discharge muffler upstream of the check valve. If the pressure in the compressor is abnormally high when the check valve closes, the relief valve releases the abnormally high pressure from the discharge muffler. Therefore, if the check valve fails to function, the relief valve prevents the pressure in the compressor from being abnormally high.

摘要翻译： 制冷剂回路包括压缩机和膨胀阀。 膨胀阀通过高压管连接到压缩机的排放消声器。 膨胀阀还通过低压导管连接到压缩机的吸入通道。 高压导管包括冷凝器，低压导管包括蒸发器。 止回阀位于排气消声器和高压管道之间，以选择性地连接和断开高压管道与排放消声器。 安全阀安装在止回阀上游的排气消声器。 如果在止回阀关闭时压缩机的压力异常高，则溢流阀会从排气消声器释放异常高的压力。 因此，如果止回阀不起作用，则安全阀防止压缩机中的压力异常高。

公开(公告)号：US4348903A

公开(公告)日：1982-09-14

申请号：US180043

申请日：1980-08-21

申请人： Ichiya Sato ,  Kazuo Miyagawa ,  Yukito Sasaki ,  Koji Kawamura ,  Shuichi Sato ,  Soji Sasaki ,  Jun Kubota ,  Susumu Itoh

发明人： Ichiya Sato ,  Kazuo Miyagawa ,  Yukito Sasaki ,  Koji Kawamura ,  Shuichi Sato ,  Soji Sasaki ,  Jun Kubota ,  Susumu Itoh

IPC分类号： G01N29/04 ,  G01N29/24 ,  G10K15/04 ,  G01N29/00

CPC分类号： G01N29/2412 ,  G10K15/04 ,  G01N2291/02854 ,  G01N2291/0421

摘要： First and second magnetic poles are provided, which have end surfaces brought close and in opposition to a material to be examined. These magnetic poles are magnetized by a DC exciter coil such that the magnetic poles have opposite polarities. The first magnetic pole is provided at its end surface with a pair of cumulatively connected transmitting coils, and the second magnetic pole is provided at its end surface with a pair of differentially connected receiving coils. The transmitting coils are connected to a pulser which generates a pulse current, and the receiving coils are connected to a differential amplifier. An electromagnetic ultrasonic wave generated by the transmitting coils are received by the receiving coils, amplified by the differential amplifier, and thereafter supplied to a synchroscope and an automatic detector.

摘要翻译： 提供了第一和第二磁极，其具有与被检查材料接近并相对的端面。 这些磁极被直流励磁线圈磁化，使得磁极具有相反的极性。 第一磁极在其端面处设置有一对累积连接的传输线圈，并且第二磁极在其端面设置有一对差分连接的接收线圈。 发送线圈连接到产生脉冲电流的脉冲发生器，并且接收线圈连接到差分放大器。 由发送线圈产生的电磁超声波由接收线圈接收，由差分放大器放大，然后供给同步机和自动检测器。