公开(公告)号：US20070048269A1

公开(公告)日：2007-03-01

申请号：US11548574

申请日：2006-10-11

申请人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

发明人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

IPC分类号： A61K38/20 ,  A61K39/395

CPC分类号： C07K14/54 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2086 ,  A61K45/06 ,  C07K16/2878 ,  C07K2317/73 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

公开(公告)号：US20070048267A1

公开(公告)日：2007-03-01

申请号：US11548202

申请日：2006-10-10

申请人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

发明人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

IPC分类号： A61K38/20 ,  A61K39/00

CPC分类号： C07K14/54 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2086 ,  A61K45/06 ,  C07K16/2878 ,  C07K2317/73 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

公开(公告)号：US20050265966A1

公开(公告)日：2005-12-01

申请号：US11134489

申请日：2005-05-20

申请人： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

发明人： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC分类号： A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32

CPC分类号： C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

摘要： Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

摘要翻译： 描述了通过用IL-21共同施用治疗性单克隆抗体来治疗癌症的方法。 可以使用的示例性单克隆抗体是利妥昔单抗，曲妥珠单抗和抗CTLA-4抗体。 联合治疗的增强的抗肿瘤剂对于单克隆治疗顽固性，用单克隆抗体治疗后复发或增强的IL-21抗肿瘤作用降低与使用单克隆抗体治疗相关的毒性的患者群体特别有用。

公开(公告)号：US06150923A

公开(公告)日：2000-11-21

申请号：US51551

申请日：1998-10-26

申请人： William Nevil Heaton Johnson ,  Christopher George Rice ,  Steven Hughes

发明人： William Nevil Heaton Johnson ,  Christopher George Rice ,  Steven Hughes

IPC分类号： G08B3/10 ,  G08B13/14 ,  G08B29/18

CPC分类号： G08B29/181 ,  G08B13/1409 ,  G08B13/149 ,  G08B3/10

摘要： An alarm system for detecting attempted theft of an article includes means incorporated in the article itself and arranged to transmit and to continuing transmitting an alarm signal when the article is removed from its original location. An example of the alarm system provides an audible alarm, or transmitted alarm, and is arranged to be operated when a thief removes or attempts to remove a car radio, cassette player, compact disc player or the like from a car. Unauthorized removal of the unit from a car is detected by the consequent breaking of an electrical circuit which may be the power supply connections to the radio from the car electrical system or may be the connections to the loudspeakers or the radio aerial.

摘要翻译： PCT No.PCT / GB96 / 02484第 371日期：1998年10月26日 102（e）1998年10月26日PCT PCT 1996年10月10日PCT公布。 公开号WO97 / 13656 PCT 日期1997年4月17日用于检测企图盗窃物品的报警系统包括结合在物品本身中的装置，并被布置成当物品从其原始位置移除时传送并继续传送报警信号。 报警系统的一个例子提供了一个声音报警器或发送的报警器，并且被安排为当小偷从汽车中移除或试图从汽车上移除汽车收音机，盒式录放机，光盘播放器等时进行操作。 通过电路的破坏可以检测到车辆未经授权的拆卸，该电路可能是从汽车电气系统到无线电的电源连接，或可以是与扬声器或无线电天线的连接。

公开(公告)号：US09159872B2

公开(公告)日：2015-10-13

申请号：US13485756

申请日：2012-05-31

申请人： Juanita Kurtin ,  Matthew J. Carillo ,  Steven Hughes

发明人： Juanita Kurtin ,  Matthew J. Carillo ,  Steven Hughes

IPC分类号： H01L29/06 ,  H01L33/04 ,  H01L21/02 ,  H01L33/50 ,  C09K11/02 ,  C09K11/56 ,  C09K11/88 ,  C01B19/00 ,  H01L33/06 ,  B82Y30/00 ,  H01L33/00 ,  B01J13/02 ,  B82Y40/00 ,  B82Y99/00

CPC分类号： H01L33/06 ,  B01J13/02 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y99/00 ,  C01B19/007 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/10 ,  C01P2004/54 ,  C01P2004/64 ,  C01P2004/80 ,  C09K11/02 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  H01L21/02422 ,  H01L21/02557 ,  H01L21/0256 ,  H01L21/02601 ,  H01L21/02628 ,  H01L33/005 ,  H01L33/04 ,  H01L33/502

摘要： Semiconductor structures having a nanocrystalline core and corresponding nanocrystalline shell are described. In an example, a semiconductor structure includes an anisotropic nanocrystalline core composed of a first semiconductor material and having an aspect ratio between, but not including, 1.0 and 2.0. The semiconductor structure also includes a nanocrystalline shell composed of a second, different, semiconductor material at least partially surrounding the anisotropic nanocrystalline core.

摘要翻译： 描述了具有纳米晶核和对应的纳米晶体壳的半导体结构。 在一个示例中，半导体结构包括由第一半导体材料构成并且具有但不包括1.0和2.0之间的纵横比的各向异性纳米晶核。 半导体结构还包括由至少部分地围绕各向异性纳米晶核的第二不同的半导体材料组成的纳米晶体壳。

公开(公告)号：US20130112940A1

公开(公告)日：2013-05-09

申请号：US13485756

申请日：2012-05-31

申请人： Juanita Kurtin ,  Matthew J. Carillo ,  Steven Hughes

发明人： Juanita Kurtin ,  Matthew J. Carillo ,  Steven Hughes

IPC分类号： H01L33/04 ,  H01L29/06 ,  H01L21/20 ,  B82Y40/00 ,  B82Y99/00

CPC分类号： H01L33/06 ,  B01J13/02 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y99/00 ,  C01B19/007 ,  C01P2002/84 ,  C01P2004/04 ,  C01P2004/10 ,  C01P2004/54 ,  C01P2004/64 ,  C01P2004/80 ,  C09K11/02 ,  C09K11/025 ,  C09K11/565 ,  C09K11/883 ,  H01L21/02422 ,  H01L21/02557 ,  H01L21/0256 ,  H01L21/02601 ,  H01L21/02628 ,  H01L33/005 ,  H01L33/04 ,  H01L33/502

摘要： Semiconductor structures having a nanocrystalline core and corresponding nanocrystalline shell are described. In an example, a semiconductor structure includes an anisotropic nanocrystalline core composed of a first semiconductor material and having an aspect ratio between, but not including, 1.0 and 2.0. The semiconductor structure also includes a nanocrystalline shell composed of a second, different, semiconductor material at least partially surrounding the anisotropic nanocrystalline core.

摘要翻译： 描述了具有纳米晶核和对应的纳米晶体壳的半导体结构。 在一个示例中，半导体结构包括由第一半导体材料构成并且具有但不包括1.0和2.0之间的纵横比的各向异性纳米晶核。 半导体结构还包括由至少部分地围绕各向异性纳米晶核的第二不同的半导体材料组成的纳米晶体壳。

公开(公告)号：US20080025946A1

公开(公告)日：2008-01-31

申请号：US11777852

申请日：2007-07-13

申请人： Pallavur Sivakumar ,  Diana Hausman ,  Steven Hughes ,  Eric Sievers ,  Dennis Miller

发明人： Pallavur Sivakumar ,  Diana Hausman ,  Steven Hughes ,  Eric Sievers ,  Dennis Miller

IPC分类号： A61K38/20 ,  A61K31/44 ,  A61P35/00

CPC分类号： A61K45/06 ,  A61K31/404 ,  A61K31/4412 ,  A61K38/20 ,  A61K2300/00

摘要： The present invention provides methods for use of IL-21 in combination with a tyrosine kinase inhibitor (TKI) in treatment of diseases in which inhibition of phosphorylation via TK inhibition and modulation of immune function play a clinically beneficial role. These diseases include, but are not limited to, cancers, such as renal cell carcinoma and metastatic melanoma.

摘要翻译： 本发明提供了将IL-21与酪氨酸激酶抑制剂（TKI）组合用于治疗通过TK抑制和调节免疫功能的磷酸化抑制发挥临床有益作用的疾病的方法。 这些疾病包括但不限于癌症，例如肾细胞癌和转移性黑素瘤。

公开(公告)号：US20070122382A1

公开(公告)日：2007-05-31

申请号：US11539493

申请日：2006-10-06

申请人： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

发明人： Wayne Kindsvogel ,  Steven Hughes ,  Richard Holly ,  Christopher Clegg ,  Donald Foster ,  Rebecca Johnson ,  Mark Heipel ,  Pallavur Sivakumar

IPC分类号： A61K39/395 ,  A61K38/20

CPC分类号： C07K16/32 ,  A61K38/20 ,  A61K39/395 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2896 ,  C07K2317/732 ,  A61K2300/00

摘要： Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

公开(公告)号：US20070049549A1

公开(公告)日：2007-03-01

申请号：US11548554

申请日：2006-10-11

申请人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

发明人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

IPC分类号： A61K48/00 ,  A61K38/20

CPC分类号： C07K14/54 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2086 ,  A61K45/06 ,  C07K16/2878 ,  C07K2317/73 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

公开(公告)号：US20070049548A1

公开(公告)日：2007-03-01

申请号：US11548538

申请日：2006-10-11

申请人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

发明人： Andrew Nelson ,  Steven Hughes ,  Richard Holly

IPC分类号： A61K48/00 ,  A61K38/20

CPC分类号： C07K14/54 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2086 ,  A61K45/06 ,  C07K16/2878 ,  C07K2317/73 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.