利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

30 条记录 (耗时 0.052 秒)

    Member of the TNF family useful for treatment and diagnosis of disease
    23.
    发明授权
    Member of the TNF family useful for treatment and diagnosis of disease 失效
    TNF家族成员可用于治疗和诊断疾病

    公开(公告)号：US06171787B2

    公开(公告)日：2001-01-09

    申请号：US08883086

    申请日：1997-06-26

    申请人： Steven R. Wiley

    发明人： Steven R. Wiley

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/70575 ,  C12Q2600/158 ,  G01N33/6863 ,  G01N33/6878 ,  G01N2333/525 ,  G01N2500/00

    摘要： An isolated clone consisting of sequences transcribed from the TNF-gamma gene. Also provided are human polypeptides translated from said TNF-gamma sequences and a procedure for producing such polypeptide by recombinant techniques. Also provided are a procedure for producing soluble biologically active TNF-gamma, which may be used to treat deficiencies of TNF-gamma and diseases conditions ameliorated by TNF-gamma. Antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat TNF-gamma associated diseases, tumors or metastastases are disclosed. Also disclosed is the use of said antibodies, agonists and inhibitors as well as the nucleic acid sequences to screen for, diagnose, prognosticate, stage and monitor conditions and diseases attributable to TNF-gamma, especially inflammation. The use of said partial sequence to provide antibodies, agonists and inhibitors as well as partial nucleic acid sequences to screen for, diagnose, stage and monitor diseases associated with TNf-gamma, including but not limited to inflammation. Illustrative sequences and clone designations for TNF-gamma are provided.

    摘要翻译： 由从TNF-γ基因转录的序列组成的分离克隆。 还提供了从所述TNF-γ序列翻译的人多肽和通过重组技术产生此类多肽的方法。 还提供了用于产生可溶性生物活性TNF-γ的方法，其可用于治疗TNF-γ的缺陷和由TNF-γ改善的疾病状态。 公开了可用于预防这种多肽作用的这种多肽的抗体，拮抗剂和抑制剂，因此可用于治疗性地治疗TNF-γ相关疾病，肿瘤或转移酶。 还公开了所述抗体，激动剂和抑制剂以及核酸序列用于筛选，诊断，预测，分期和监测归因于TNF-γ，特别是炎症的病症和疾病的用途。 使用所述部分序列提供抗体，激动剂和抑制剂以及部分核酸序列来筛选，诊断，分期和监测与TNf-γ相关的疾病，包括但不限于炎症。 提供了用于TNF-γ的说明性序列和克隆名称。

    Antibodies directed against trail
    29.
    发明授权
    Antibodies directed against trail 有权
    针对抗体的抗体

    公开(公告)号：US06521228B1

    公开(公告)日：2003-02-18

    申请号：US09825563

    申请日：2001-04-02

    申请人： Steven R. Wiley ,  Raymond G. Goodwin

    发明人： Steven R. Wiley ,  Raymond G. Goodwin

    IPC分类号： A61K39395

    CPC分类号： C07K14/70575 ,  C07K16/24 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/74

    摘要： A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

    摘要翻译： 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。

    Cytokine that induces apoptosis
    30.
    发明授权
    Cytokine that induces apoptosis 有权
    诱导凋亡的细胞因子

    公开(公告)号：US06284236B1

    公开(公告)日：2001-09-04

    申请号：US09320424

    申请日：1999-05-26

    申请人： Steven R. Wiley ,  Raymond G. Goodwin

    发明人： Steven R. Wiley ,  Raymond G. Goodwin

    IPC分类号： A61K3819

    CPC分类号： C07K14/70575 ,  C07K16/24 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/74

    摘要： A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.

    摘要翻译： 称为TRAIL的新型细胞因子诱导某些靶细胞的凋亡，包括癌细胞和病毒感染的细胞。 公开了编码TRAIL的分离的DNA序列，以及可用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。