专利检索 ap:("Marc Gaston Venet" OR "Patrick René Angibaud" OR "David William End") AND inv:"Patrick René Angibaud" 第 3 页

21.

发明授权
Inhibitors of histone deacetylase 有权
标题翻译：组蛋白脱乙酰酶抑制剂

公开(公告)号：US08343988B2

公开(公告)日：2013-01-01

申请号：US12372785

申请日：2009-02-18

申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin

发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Sven Franciscus Anna Van Brandt , Bruno Roux , Peter Ten Holte , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Alexey Borisovich Dyatkin

IPC分类号： A01N43/54 , A61K31/505 , C07D401/00

CPC分类号： C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D211/14 , C07D211/58 , C07D213/78 , C07D217/02 , C07D217/04 , C07D217/16 , C07D239/42 , C07D295/155 , C07D295/26 , C07D307/68 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48

摘要： This invention comprises the novel compounds of formula (I) wherein n, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括其中n，t，R 1，R 2，R 3，R 4，L，Q，X，Y，Z并具有定义的具有组蛋白脱乙酰酶抑制酶活性的式（I）化合物。其制剂，含有它们的组合物及其作为药物的用途。

22.

发明授权
Aminophenyl derivatives as novel inhibitors of histone deacetylase 有权
标题翻译：氨基苯基衍生物作为组蛋白脱乙酰酶的新型抑制剂

公开(公告)号：US08119650B2

公开(公告)日：2012-02-21

申请号：US12160140

申请日：2007-01-16

申请人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Bruno Roux , Janine Arts

发明人： Patrick René Angibaud , Isabelle Noëlle Constance Pilatte , Bruno Roux , Janine Arts

IPC分类号： C07D401/14 , A61K31/4439

CPC分类号： C07D401/14 , C07D405/14 , C07D409/14

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，X和Y具有定义含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

23.

发明授权
Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase 有权
标题翻译：吡啶和嘧啶衍生物作为组蛋白脱乙酰酶的抑制剂

公开(公告)号：US08114876B2

公开(公告)日：2012-02-14

申请号：US12160124

申请日：2007-01-16

申请人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud

发明人： Laurence Françoise Bernadette Marconnet-Decrane , Sandrine Françoise Dominique Gaurrand , Patrick René Angibaud

IPC分类号： C07D239/42 , C07D403/12 , A61K31/506

CPC分类号： A61K31/496 , A61K45/06 , C07D213/78 , C07D213/82 , C07D239/42 , C07D403/12 , C07D409/14 , Y02A50/411

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3和X具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。

24.

发明申请
QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS 有权
标题翻译：喹诺酮衍生物作为PARP和油墨抑制剂

公开(公告)号：US20100168065A1

公开(公告)日：2010-07-01

申请号：US12529142

申请日：2008-03-07

申请人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Francoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet

发明人： Jorge Eduardo Vialard , Patrick René Angibaud , Laurence Anne Mevellec , Christophe Meyer , Eddy Jean Edgard Freyne , Isabelle Noëlle Pilatte , Bruno Roux , Elisabeth Thérèse Jeanne Pasquier , Xavier Marc Bourdrez , Christophe Denis Adelinet , Laurence Francoise Bernadette Marconnet-Decrane , Jacqueline Anne Macritchie , James Edward Stewart Duffy , Andrew Pate Owens , Pierre-Henri Storck , Virginie Sophie Poncelet

IPC分类号： A61K31/675 , C07D215/227 , A61K31/4704 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/496 , A61K31/506 , C07F9/38 , A61K31/502 , A61K31/498 , C07D471/04 , A61K31/437 , A61P35/00

CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06

摘要： The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, n, m and X have defined meanings.

摘要翻译： 本发明提供式（I）化合物，它们作为PARP抑制剂的用途以及包含所述式（I）化合物的药物组合物，其中R1，R2，R3，R4，R5，R6，R7，n，m和X具有定义含义。

25.

发明授权
Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases 有权
标题翻译：咪唑并吡啶衍生物作为受体酪氨酸激酶的抑制剂

公开(公告)号：US08796244B2

公开(公告)日：2014-08-05

申请号：US12997754

申请日：2009-06-12

申请人： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud , Marian Williams

发明人： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud

IPC分类号： A61K31/5025 , C07D413/02

CPC分类号： C07D471/04 , C07D513/04

摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

摘要翻译： 本发明涉及新的双环杂环衍生物化合物，包含该化合物的药物组合物和该化合物在治疗疾病中的用途。癌症。

26.

发明申请
SUBSTITUTED BENZOPYRAZIN DERIVATIVES AS FGFR KINASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES 有权
标题翻译：作为FGFR激酶抑制剂治疗癌症疾病的替代苯并噻嗪衍生物

公开(公告)号：US20130267525A1

公开(公告)日：2013-10-10

申请号：US13990193

申请日：2011-11-29

申请人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud

发明人： Gordon Saxty , Christopher William Murray , Valerio Berdini , Gilbert Ebai Besong , Christopher Charles Frederick Hamlett , Steven John Woodhead , Yannick Aime Eddy Ligny , Patrick René Angibaud

IPC分类号： C07D403/04 , C07D401/14 , C07D403/14

CPC分类号： C07D403/04 , C07D401/14 , C07D403/14

摘要： The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

摘要翻译： 本发明涉及新的喹喔啉衍生物化合物，包含所述化合物的药物组合物，用于制备所述化合物的方法和所述化合物在治疗疾病中的用途。癌症。

27.

发明授权
Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权
标题翻译：取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂

公开(公告)号：US08524728B2

公开(公告)日：2013-09-03

申请号：US13027793

申请日：2011-02-15

申请人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen

发明人： Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen

IPC分类号： A61K31/506 , C07D401/14

CPC分类号： A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056

摘要： This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

摘要翻译： 本发明包括式（I）的新化合物，其中R1，R2，R3，X和Y具有定义的含义，具有组蛋白脱乙酰酶抑制酶活性; 其制剂，含有它们的组合物及其作为药物的用途。