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    Microfabricated instrument for tissue biopsy and analysis
    22.
    发明授权
    Microfabricated instrument for tissue biopsy and analysis 失效
    用于组织活检和分析的微型仪器

    公开(公告)号：US06319474B1

    公开(公告)日：2001-11-20

    申请号：US09327401

    申请日：1999-06-07

    申请人： Peter A. Krulevitch ,  Abraham P. Lee ,  M. Allen Northrup ,  William J. Benett

    发明人： Peter A. Krulevitch ,  Abraham P. Lee ,  M. Allen Northrup ,  William J. Benett

    IPC分类号： B01L1100

    CPC分类号： G01N1/31 ,  G01N1/06 ,  Y10T83/222 ,  Y10T83/9493

    摘要： A microfabricated biopsy/histology instrument which has several advantages over the conventional procedures, including minimal specimen handling, smooth cutting edges with atomic sharpness capable of slicing very thin specimens (approximately 2 &mgr;m or greater), micro-liter volumes of chemicals for treating the specimens, low cost, disposable, fabrication process which renders sterile parts, and ease of use. The cutter is a “cheese-grater” style design comprising a block or substrate of silicon and which uses anisotropic etching of the silicon to form extremely sharp and precise cutting edges. As a specimen is cut, it passes through the silicon cutter and lies flat on a piece of glass which is bonded to the cutter. Microchannels are etched into the glass or silicon substrates for delivering small volumes of chemicals for treating the specimen. After treatment, the specimens can be examined through the glass substrate.

    摘要翻译： 一种微加工活检/组织学仪器，其具有优于常规程序的几个优点，包括最小的样品处理，具有能够切割非常薄的样品（约2μm或更大）的原子清晰度的平滑切割边缘，用于处理样品的微量体积的化学品 ，低成本，一次性的制造工艺，使无菌部件和易于使用。 切割器是包括硅块或硅衬底的“干酪磨”式设计，其使用硅的各向异性蚀刻来形成非常清晰和精确的切割边缘。 当样品被切割时，它通过硅切割器并且平坦地放置在粘合到切割器上的一块玻璃上。 将微通道蚀刻到玻璃或硅衬底中，用于递送少量用于处理样品的化学品。 处理后，可以通过玻璃基板检查样品。

    Microfabricated therapeutic actuators
    23.
    发明授权
    Microfabricated therapeutic actuators 失效
    微型治疗执行器

    公开(公告)号：US5911737A

    公开(公告)日：1999-06-15

    申请号：US807412

    申请日：1997-02-28

    申请人： Abraham P. Lee ,  M. Allen Northrup ,  Dino R. Ciarlo ,  Peter A. Krulevitch ,  William J. Benett

    发明人： Abraham P. Lee ,  M. Allen Northrup ,  Dino R. Ciarlo ,  Peter A. Krulevitch ,  William J. Benett

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61M25/16 ,  A61B17/28

    CPC分类号： A61B17/1214 ,  A61B17/12022 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2017/12068 ,  A61B2017/12077

    摘要： Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a release actuator for the delivery of embolic coils through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use.

    摘要翻译： 使用形状记忆聚合物（SMP），在特定温度（Tg）下经历相变的基于聚氨酯的材料制造微制剂治疗致动器。 在高于温度的温度下，Tg材料是柔软的并且可以容易地重塑成另一种构型。 当温度降低到温度Tg以下时，只要材料保持低于温度Tg，新形状就会被固定和锁定。 将材料重新加热至高于Tg的温度时，材料将恢复到原来的形状。 通过使用这种SMP材料，SMP微管可以用作例如通过导管将栓塞线圈输送到动脉瘤中的释放致动器。 微管可以以各种尺寸制造，相变温度Tg对于预期的温度目标和预期用途是确定的。

    Expandable Implant and Implant System
    29.
    发明申请
    Expandable Implant and Implant System 有权
    可扩展植入物和植入系统

    公开(公告)号：US20120158034A1

    公开(公告)日：2012-06-21

    申请号：US13325906

    申请日：2011-12-14

    申请人： Thomas S. Wilson ,  Ward Small, IV ,  William J. Benett ,  Jason M. Ortega ,  Duncan J. Maitland ,  Jonathan Hartman

    发明人： Thomas S. Wilson ,  Ward Small, IV ,  William J. Benett ,  Jason M. Ortega ,  Duncan J. Maitland ,  Jonathan Hartman

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12163 ,  A61B17/12181 ,  A61B2017/00871 ,  A61B2017/12054 ,  A61M25/0668 ,  A61M2025/0042

    摘要： An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.

    摘要翻译： 本发明的一个实施方案包括可扩张植入物以血管内栓塞解剖空洞或畸形，例如动脉瘤。 一个实施方案由可扩张聚合物泡沫元件的链或连接序列组成。 另一个实施方案包括连接到骨架的细长长度的可发性聚合物泡沫。 另一实施例包括用于栓塞动脉瘤的可扩张植入物（例如，形状记忆聚合物）的血管内递送的系统。 系统可以包括微导管，联接到微导管的远端的管腔减小套管，可拆卸地联接到可扩张植入物的柔性推动元件，以及柔性管状护套，内部压缩的植入物和推动元件被预加载 。 本文描述了其它实施例。