Shape Memory Polymers
    3.
    发明申请
    Shape Memory Polymers 有权
    形状记忆聚合物

    公开(公告)号:US20110039967A1

    公开(公告)日:2011-02-17

    申请号:US12905949

    申请日:2010-10-15

    摘要: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxyl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.

    摘要翻译: 新形状记忆聚合物组合物,用于合成新形状记忆聚合物的方法,以及包括致动器和形状记忆聚合物的装置,其中形状记忆聚合物包括致动器的至少一部分。 一种形状记忆聚合物,其包含物理形成网状结构的聚合物组合物,其中所述聚合物组合物具有形状记忆行为并且可以形成为永久性初级形状,重新形成稳定的二次形状,并且可控地致动以恢复永久性初级 形状。 聚合物具有最佳的脂肪族网络结构,因为通过使用对称的单体使悬挂链最小化,并且具有匹配的胺和羟基,提供具有透明度,紧密(窄温度范围)单一过渡的聚合物和聚合物泡沫以及高形状恢复和恢复力 这对植入人体尤其有用。

    Shape memory polymers
    5.
    发明授权
    Shape memory polymers 有权
    形状记忆聚合物

    公开(公告)号:US09051411B2

    公开(公告)日:2015-06-09

    申请号:US12905949

    申请日:2010-10-15

    摘要: New shape memory polymer compositions, methods for synthesizing new shape memory polymers, and apparatus comprising an actuator and a shape memory polymer wherein the shape memory polymer comprises at least a portion of the actuator. A shape memory polymer comprising a polymer composition which physically forms a network structure wherein the polymer composition has shape-memory behavior and can be formed into a permanent primary shape, re-formed into a stable secondary shape, and controllably actuated to recover the permanent primary shape. Polymers have optimal aliphatic network structures due to minimization of dangling chains by using monomers that are symmetrical and that have matching amine and hydroxyl groups providing polymers and polymer foams with clarity, tight (narrow temperature range) single transitions, and high shape recovery and recovery force that are especially useful for implanting in the human body.

    摘要翻译: 新形状记忆聚合物组合物,用于合成新形状记忆聚合物的方法,以及包括致动器和形状记忆聚合物的装置,其中形状记忆聚合物包括致动器的至少一部分。 一种形状记忆聚合物,其包含物理形成网状结构的聚合物组合物,其中所述聚合物组合物具有形状记忆行为并且可以形成为永久性初级形状,重新形成稳定的二次形状,并且可控地致动以恢复永久性初级 形状。 聚合物具有最佳的脂肪族网络结构,因为通过使用对称的单体使悬挂链最小化,并且具有匹配的胺和羟基,提供具有透明度,紧密(窄温度范围)单一过渡的聚合物和聚合物泡沫以及高形状恢复和恢复力 这对植入人体尤其有用。

    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION
    7.
    发明申请
    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION 有权
    点保护核酸放大和检测的方法和装置

    公开(公告)号:US20140356874A1

    公开(公告)日:2014-12-04

    申请号:US14262683

    申请日:2014-04-25

    IPC分类号: C12Q1/68

    摘要: Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.

    摘要翻译: 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器,其可任选地以多路复用方式使用以检测目标的多个靶核酸序列,并且可任选地配置为在一次使用后进行处置。 该仪器优选使用等温核酸扩增技术,例如环介导的等温扩增(LAMP),以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测加入到扩增反应中的染料中的色移或荧光来实现。 这种检测可以由操作者视觉执行,或者可以使用成像技术(例如分光光度成像)来实现。

    Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion
    8.
    发明授权
    Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion 有权
    用两亲性硫醚涂覆疏水表面以减少蛋白质吸附和细胞粘附

    公开(公告)号:US07427410B2

    公开(公告)日:2008-09-23

    申请号:US10246362

    申请日:2002-09-18

    IPC分类号: A61F2/00 A61K38/43 C12N11/08

    CPC分类号: A61L27/34 C08L81/02

    摘要: The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This reduction may be achieved, for example, by controlling the spacing or length of pendant chains or hydrophilic blocks in an amphiphilic thioether. Techniques for determining spacing include adsorbing the thioether from a solution or a colloidal suspension, or controlling the degree of polymerization of the thioether. Techniques for controlling the length of the pendant chains include controlling the degree of polymerization of the pendant chains. Multiblock copolymers of poly(propylene sulfide) and poly(ethylene glycol) (“PPS-PEG”) represent an exemplary family of amphiphilic thioethers. Methods for coating surfaces with amphiphilic thioethers are also provided.

    摘要翻译: 本发明提供了用特别设计的硫醚和两亲性硫醚涂覆表面的方法和设备,其减少蛋白质吸附和/或细胞粘附。 该还原可以通过例如通过控制两亲性硫醚中的侧链或亲水嵌段的间隔或长度来实现。 用于确定间隔的技术包括从溶液或胶体悬浮液中吸附硫醚,或控制硫醚的聚合度。 用于控制侧链长度的技术包括控制侧链的聚合度。 聚(丙烯硫醚)和聚(乙二醇)(“PPS-PEG”)的多嵌段共聚物代表两亲性硫醚的典型族。 还提供了用两亲硫醚涂覆表面的方法。

    Methods and apparatus for selective, oxidative patterning of a surface
    10.
    发明授权
    Methods and apparatus for selective, oxidative patterning of a surface 有权
    用于表面选择性,氧化图案化的方法和装置

    公开(公告)号:US08119335B2

    公开(公告)日:2012-02-21

    申请号:US11333090

    申请日:2006-01-17

    IPC分类号: C08F2/54 C08F2/48 G03F7/00

    摘要: The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.

    摘要翻译: 本发明提供了使用由光催化剂生成的自由基物质来选择性地图案化表面的方法和装置。 光催化剂可以包含光催化半导体或光敏剂。 使自由基物质与设置在表面上的可氧化涂层接触,从而局部氧化并选择性地图案化该表面。 光催化剂优选地设置在与涂覆表面紧密接触或接触的输送装置,例如印模,掩模或扫描探针上。 然后在适当的介质中以能够产生自由基物质,例如含氧自由基物质的方式激发光催化剂。 预期这些自由基物质将沿着基本上最短的距离路径转移到涂覆的表面,从而局部氧化和图案化表面。