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28 条记录 (耗时 0.045 秒)

    PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT
    22.
    发明申请
    PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT 有权
    苯基取代的马来酰亚胺作为通过抑制MPT阻断变性组织损伤的药物

    公开(公告)号：US20100099736A1

    公开(公告)日：2010-04-22

    申请号：US12444407

    申请日：2007-09-21

    申请人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

    发明人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

    IPC分类号： A61K31/4015 ,  A61P25/00 ,  A61P3/10

    CPC分类号： A61K31/4025 ,  C07D207/444 ,  C07D207/448 ,  C07D207/452 ,  Y10S514/866

    摘要： The invention discloses the use of a compound of formula (I), wherein R1, R2, R3, and R4 each independently represents: hydrogen; halo; hydroxy; (C1-C6) alkyl optionally substituted by hydroxy or (C1-C4) alkoxy; (C1-C6) haloalkyl; (C1-C6) alkoxy; and (C1-C6) haloalkoxy; for the preparation of a medicament for the prevention and/or treatment of diseases resulting from opening of the MPTP which are characterized by degenerative tissue damages, in particular, diabetes and diabetic complications, neurological diseases and stroke, heart infarction, inherited dystrophies and hepatitis, more particularly, diabetic vascular diseases, such as diabetic retinopathy, and neurodegenerative disorders, such as multiple sclerosis. Further objects are a group of selected individual compounds of formula (I) for use as medicaments and a further group of selected individual compounds of formula (I) as novel compounds.

    摘要翻译： 本发明公开了式（I）化合物的用途，其中R 1，R 2，R 3和R 4各自独立地表示：氢; 光环; 羟基; 任选被羟基或（C 1 -C 4）烷氧基取代的（C 1 -C 6）烷基; （C 1 -C 6）卤代烷基; （C 1 -C 6）烷氧基; 和（C 1 -C 6）卤代烷氧基; 用于制备用于预防和/或治疗MPTP开放引起的疾病的药物，其特征在于退行性组织损伤，特别是糖尿病和糖尿病并发症，神经系统疾病和中风，心脏梗死，遗传性营养不良和肝炎， 更具体地，糖尿病性血管疾病，例如糖尿病性视网膜病变，和神经变性疾病如多发性硬化。 另外的目的是用作药物的一组选定的式（I）化合物和另一组选择的式（I）化合物作为新化合物。

    Topical Use of Valproic Acid for the Prevention or Treatment of Skin Disorders
    27.
    发明申请
    Topical Use of Valproic Acid for the Prevention or Treatment of Skin Disorders 审中-公开
    专门用于丙戊酸预防或治疗皮肤疾病

    公开(公告)号：US20060160897A1

    公开(公告)日：2006-07-20

    申请号：US11275258

    申请日：2005-12-21

    申请人： Pier Pelicci ,  Sergio Chimenti ,  Antonio Costanzo ,  Steven Nistico ,  Donatella Paolino ,  Saverio Minucci

    发明人： Pier Pelicci ,  Sergio Chimenti ,  Antonio Costanzo ,  Steven Nistico ,  Donatella Paolino ,  Saverio Minucci

    IPC分类号： A61K31/19

    CPC分类号： A61K31/20 ,  A61K31/19 ,  A61K31/4436 ,  A61K31/505 ,  A61K2300/00

    摘要： The present invention relates to a topically applicable formulation containing Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclear receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre-malignant lesions, and of inflammations of the skin and/or mucosa. The invention also relates to the use of this topically applicable formulation for the protection from UV light and for the treatment of sun burn. The invention includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.

    摘要翻译： 本发明涉及含有丙戊酸或其衍生物的局部应用制剂，其可以单独使用或与局部应用的类视黄醇或核受体配体的制剂或化学治疗剂（例如5-氟尿嘧啶）组合使用。 该制剂可用于局部治疗癌性皮肤病，例如基底细胞癌，鳞状细胞癌，角化细胞瘤，鲍氏病，皮肤T细胞淋巴瘤，以及用于局部治疗恶性前病变，以及 皮肤和/或粘膜。 本发明还涉及这种局部适用的制剂用于防止紫外线和用于治疗太阳灼伤的用途。 本发明包括使用VPA制造用于局部治疗上述人类疾病的临床用药物。