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    Methods of using an array of pooled probes in genetic analysis
    24.
    发明授权
    Methods of using an array of pooled probes in genetic analysis 有权
    在遗传分析中使用汇集探针阵列的方法

    公开(公告)号：US06306643B1

    公开(公告)日：2001-10-23

    申请号：US09138958

    申请日：1998-08-24

    Applicant: Erik Gentalen ,  Mark Chee

    Inventor： Erik Gentalen ,  Mark Chee

    IPC: C12M134

    CPC classification number: C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q2565/543 ,  C12Q2565/513

    Abstract: The invention provides arrays of polynucleotide probes having at least one pooled position. A typical array comprises a support having at least three discrete regions. A first region bears a pool of polynucleotide probes comprising first and second probes. A second region bears the first probe without the second probe and a third region bears the second probe without the first probe. A target nucleic acid having segments complementary to both the first and second probes shows stronger normalized binding to the first region than to the aggregate of binding to the second and third regions due to cooperative binding of pooled probes in the first region. The invention provide methods of using such arrays for e.g., linkage analysis, sequence analysis, and expression monitoring.

    Abstract translation: 本发明提供具有至少一个合并位置的多核苷酸探针阵列。 典型的阵列包括具有至少三个离散区域的支撑件。 第一区域具有包含第一和第二探针的多核苷酸探针池。 第二区域承载第一探针而没有第二探针，第三区域承载第二探针而没有第一探针。 具有与第一和第二探针两者互补的区段的靶核酸由于在第一区域中的合并探针的协同结合而显示比第一区域更强的标准化结合，而不是与第二和第三区域结合的聚集体。 本发明提供了使用这种阵列进行例如连锁分析，序列分析和表达监测的方法。

    Polymorphisms in the glucose-6 phosphate dehydrogenase locus
    27.
    发明授权
    Polymorphisms in the glucose-6 phosphate dehydrogenase locus 失效
    葡萄糖-6-磷酸脱氢酶基因座的多态性

    公开(公告)号：US5856104A

    公开(公告)日：1999-01-05

    申请号：US813508

    申请日：1997-03-07

    Applicant: Mark Chee ,  Jian-Bing Fan

    Inventor： Mark Chee ,  Jian-Bing Fan

    IPC: C12Q1/68 ,  C07H21/04

    CPC classification number: C12Q1/6827 ,  C12Q1/6876 ,  C12Q2600/156

    Abstract: The invention provides nucleic acid segments of the glucose-6 phosphate dehydrogenase locus of the human genome including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as forensics, paternity testing, medicine and genetic analysis.

    Abstract translation: 本发明提供人类基因组的葡萄糖-6-磷酸脱氢酶基因座的核酸片段，包括多态位点。 还提供了与这些位点侧翼区域杂交的等位基因特异性引物和探针。 核酸，引物和探针用于取证，亲子鉴定，药物和遗传分析等应用。

    Methods of using an array of pooled probes in genetic analysis
    29.
    发明授权
    Methods of using an array of pooled probes in genetic analysis 有权
    在遗传分析中使用汇集探针阵列的方法

    公开(公告)号：US08586312B2

    公开(公告)日：2013-11-19

    申请号：US12858237

    申请日：2010-08-17

    Applicant: Erik Gentalen ,  Mark Chee

    Inventor： Erik Gentalen ,  Mark Chee

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC classification number: C12Q1/6837 ,  C12Q1/6827 ,  C12Q1/6874 ,  C12Q2565/543 ,  C12Q2565/513

    Abstract: The invention provides arrays of polynucleotide probes having at least one pooled position. A typical array comprises a support having at least three discrete regions. A first region bears a pool of polynucleotide probes comprising first and second probes. A second region bears the first probe without the second probe and a third region bears the second probe without the first probe. A target nucleic acid having segments complementary to both the first and second probes shows stronger normalized binding to the first region than to the aggregate of binding to the second and third regions due to cooperative binding of pooled probes in the first region. The invention provides methods of using such arrays for e.g., linkage analysis, sequence analysis, and expression monitoring.

    Abstract translation: 本发明提供具有至少一个合并位置的多核苷酸探针阵列。 典型的阵列包括具有至少三个离散区域的支撑件。 第一区域具有包含第一和第二探针的多核苷酸探针池。 第二区域承载第一探针而没有第二探针，第三区域承载第二探针而没有第一探针。 具有与第一和第二探针两者互补的区段的靶核酸由于在第一区域中的合并探针的协同结合而显示比第一区域更强的标准化结合，而不是与第二和第三区域结合的聚集体。 本发明提供了使用这种阵列进行例如连锁分析，序列分析和表达监测的方法。

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