摘要:
The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.
摘要:
An apparatus for remotely operating a computer using a combination of voice commands and finger movements. The apparatus includes a microphone and a plurality of control elements in the form of touch-sensitive touchpads and/or motion-sensitive elements that are used to operate the computer and to move an on-screen cursor. At least one touchpad is used to selectively switch between a command-mode of operation in which the computer interprets spoken words as commands for operating the computer and any software applications being used, and a text-mode of operation in which the computer interprets spoken words literally as text to be inserted into a software application. The apparatus is ergonomically designed to enable it to be easily worn and to enable a user to operate a computer from a standing, sitting or reclining position. The apparatus can be used to operate a computer for traditional computing purposes such as word processing or browsing the Internet, or for other purposes such as operating electronic devices such as a television and/or other household appliances. The apparatus eliminates the need for a keyboard and a mouse to operate a computer. In addition, the apparatus can be used as a telephone.
摘要:
Techniques to make e-mail correspondent-centric rather than message-centric, and reduce junk e-mail. Tabulates, maintains, and updates useful information about the user's chosen correspondents, and the history and status of each correspondence series. Filters incoming messages from an unrecognized sender, asking user whether to add sender to correspondent list, and if so prompts user for needed information. Eliminates the need to search for e-mail addresses. Facilitates viewing sequential messages to and from a correspondent. Provides an effective tool to eliminate junk-mail by making it simpler and more practical to screen messages or change one's e-mail address. When user changes his e-mail address, automates notification of user's chosen correspondents, and in some cases can automatically update such correspondents' e-mail address lists. Eliminates need to manually create and maintain mailboxes or folders. Allows automated organization of e-mail by correspondent. Is easier to learn and use than previous forms of e-mail.
摘要:
A mixed matrix membrane for separating gas components from a mixture of gas components is disclosed. The membrane comprises a continuous phase polymer with inorganic porous particles, preferably molecular sieves, interspersed in the polymer. The polymer has a CO2/CH4 selectivity of at least 20 and the porous particles have a mesoporosity of at least 0.1 cc STP/g. The mixed matrix membrane exhibits an increase in permeability of least 30% with any decrease in selectivity being no more than 10% relative to a membrane made of the neat polymer. The porous particles may include, but are not limited to, molecular sieves such as CVX-7 and SSZ-13, and/or other molecular sieves having the required mesoporosity. A method for making the mixed matrix membrane is also described. Further, a method is disclosed for separating gas components from a mixture of gas components using the mixed matrix membrane with mesoporous particles.
摘要:
A launcher includes a plurality of launch tubes for stowing and launching a plurality of air vehicles. A central air manifold is operatively connected to an air storage tank; a first launch tube air manifold is operatively connected to a first group of the launch tubes and operatively connected to the central air manifold. The first launch tube air manifold has a separate port corresponding to each launch tube of the first group of launch tubes. A release valve mechanism is removably mounted in one of the ports of the first launch tube air manifold, the release valve mechanism controlling the passage of launch air between the first launch tube air manifold and the launch tube corresponding to the port in which the release valve mechanism is mounted. A plug is removably mounted in each of the ports not occupied by the release valve mechanism.
摘要:
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
摘要:
Lubricant blends and finished gear oils comprising a lubricant base oil fraction derived from highly paraffinic wax, a petroleum derived base oil, and a pour point depressant are provided. The lubricant base oil fraction derived from highly paraffinic wax comprises less than 0.30 weight percent aromatics, greater than 5 weight percent molecules with cycloparaffinic functionality, and a ratio of weight percent of molecules with monocycloparaffinic functionality to weight percent of molecules with multicycloparaffinic functionality greater than 15. The petroleum derived base oils comprises greater than 90 weight percent saturates and less than 300 ppm sulfur and is preferably selected from the group consisting of a Group II base oil, a Group III base oil, and mixtures thereof. These lubricant blends have surprising low Brookfield viscosities at −40° C.
摘要:
A method for preparing low toxicity Fischer-Tropsch fuels suitable for use in a diesel engine and Fischer-Tropsch derived fuel compositions having low toxicity suitable for use in diesel engines characterized by a boiling range distribution wherein the 5 weight percent point is at a temperature of 570 degrees F. or less and the 95 weight percent point is at or above a temperature of 680 degrees F.; a kinematic viscosity at 40 degrees C. of less than 5.5 cSt; and a cloud point of less than −18 degrees C.
摘要:
The present application relates to methods for producing a lubricant base oil from a waxy hydrocarbon feed using a pre-sulfided shape selective, intermediate pore size, noble metal-containing molecular sieve catalyst. According to the present invention, a shape selective, intermediate pore size, noble metal-containing molecular sieve catalyst is pre-sulfided to provide a sulfided catalyst, wherein the molar ratio of sulfur to noble metal in the sulfided catalyst is greater than one, and a waxy hydrocarbon feed is hydroisomerized by contacting the waxy hydrocarbon feed with the sulfided catalyst at hydroisomerization conditions, to produce a lubricant base oil.
摘要:
A mixed matrix membrane is provided which comprises a continuous phase organic polymer and small pore molecular sieves dispersed therein. The molecular sieves have a largest minor crystallographic free diameter of 3.6 Angstroms or less. When these molecular sieves are properly interspersed with a continuous phase polymer, the membrane will exhibit a mixed matrix membrane effect, i.e., a selectivity increase of at least 10% relative to a neat membrane containing no molecular sieves. Finally, methods for making and using such mixed matrix membranes to separate gases from a mixture containing two or more gases are also disclosed.