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    Alphavirus vectors having attentuated virion structural proteins
    23.
    发明申请
    Alphavirus vectors having attentuated virion structural proteins 审中-公开
    具有病毒粒子结构蛋白的甲病毒载体

    公开(公告)号：US20060099587A1

    公开(公告)日：2006-05-11

    申请号：US10517083

    申请日：2003-06-20

    申请人： Robert Johnston ,  Nancy Davis ,  Ande West ,  Jonathan Smith

    发明人： Robert Johnston ,  Nancy Davis ,  Ande West ,  Jonathan Smith

    IPC分类号： C12Q1/68 ,  C12N7/00 ,  C12N7/01

    CPC分类号： C07K14/005 ,  A61K2039/5154 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  C12N15/86 ,  C12N2740/16222 ,  C12N2770/36122 ,  C12N2770/36143

    摘要： The present invention provides immunogenic compositions and methods that may be used to administer safer (i.e., attenuated) alphavirus vectors (such as alphavirus vectors comprising a VEE virion shell) that retain improved immunogenicity as compared with other attenuated alphaviruses (e.g., the VEE 3014 mutant, described below). In particular embodiments of the invention, the alphavirus vector comprises VEE structural proteins comprising an attenuating mutation in the E1 glycoprotein. In other particular embodiments, the attenuating mutation is in the fusogenic region of the E1 glycoprotein. The present invention enables administration of lower dosages of a safer (i.e., attenuated) virus and, thus, can further reduce manufacturing costs. The present inventors have found that immunogenicity of alphavirus vectors may be influenced by a number of factors including species, site and route of administration.

    摘要翻译： 本发明提供免疫原性组合物和方法，其可用于与其他减毒的甲病毒（例如，VEE 3014突变体）相比，其保持更高（即减毒）的甲病毒载体（例如包含VEE病毒粒子的甲病毒载体），其保持改善的免疫原性 ， 如下面所描述的）。 在本发明的具体实施方案中，甲病毒载体包含在E1糖蛋白中包含减毒突变的VEE结构蛋白。 在其它具体实施方案中，减毒突变位于E1糖蛋白的融合区。 本发明使得能够施用较低剂量的更安全（即，减毒）的病毒，因此可以进一步降低制造成本。 本发明人已经发现甲病毒载体的免疫原性可能受许多因素的影响，包括物种，部位和给药途径。

    Migrating data integration processes through use of externalized metadata representations
    25.
    发明申请
    Migrating data integration processes through use of externalized metadata representations 审中-公开
    通过使用外部化元数据表示来迁移数据集成过程

    公开(公告)号：US20050251533A1

    公开(公告)日：2005-11-10

    申请号：US11083040

    申请日：2005-03-16

    申请人： Richard Harken ,  Robert Johnston

    发明人： Richard Harken ,  Robert Johnston

    IPC分类号： G06F7/00 ,  G06F17/22

    CPC分类号： G06F17/2247 ,  G06F17/2264

    摘要： Methods and systems are provided for migrating a data integration facility, such as an ETL job, from a source data integration platform to a target data integration platform. Certain embodiments involve externalizing a metadata representation of a source data integration job; parsing the metadata representation; importing the parsed metadata into a plurality of object representations of the source data integration job; generating an intermediate representation of the source data integration platform based on the plurality of object representations; and translating the intermediate representation to generate a target data integration job; wherein the target data integration job is adapted perform substantially the same functions as the source data integration job.

    摘要翻译： 提供了方法和系统，用于将数据集成工具（如ETL作业）从源数据集成平台迁移到目标数据集成平台。 某些实施例涉及外部化源数据集成作业的元数据表示; 解析元数据表示; 将解析的元数据导入到源数据集成作业的多个对象表示中; 基于所述多个对象表示生成所述源数据集成平台的中间表示; 以及翻译所述中间表示以生成目标数据集成作业; 其中所述目标数据集成作业适于执行与所述源数据集成作业基本相同的功能。

    Topical cooling device
    26.
    发明授权
    Topical cooling device 失效
    局部冷却装置

    公开(公告)号：US6023932A

    公开(公告)日：2000-02-15

    申请号：US139868

    申请日：1998-08-25

    申请人： Robert Johnston

    发明人： Robert Johnston

    IPC分类号： A61B17/00 ,  A61F7/00 ,  F25B21/02

    CPC分类号： A61F7/007 ,  F25B21/02 ,  A61B2017/00119 ,  A61F2007/0075 ,  A61F2007/0086 ,  F25B2321/0251

    摘要： A portable topical heat transfer device for topically cooling an animal or human when required such as to relieve pain and swelling from injured joints or muscles or the like. The device comprises a thermoelectric unit having a cold side and a warm side, a DC source which is connected to the thermoelectric unit, a heat sink which is mounted in a heat conductive relationship with the warm side of the thermoelectric unit, a fan for removing heat from the heat sink, and a strap or the like for securing the device to the body of a person.

    摘要翻译： 一种便携式局部传热装置，用于在需要时局部冷却动物或人，以减轻受伤关节或肌肉等的疼痛和肿胀。 该装置包括具有冷侧和暖侧的热电单元，连接到热电单元的DC源，与热电单元的暖侧以热传导关系安装的散热器，用于去除 来自散热器的热量以及用于将设备固定在人体上的带子等。

    Apparatus and method for storing and providing a portion of media content to a communication device
    27.
    发明授权
    Apparatus and method for storing and providing a portion of media content to a communication device 有权
    一种用于存储和提供媒体内容的一部分到通信设备的装置和方法

    公开(公告)号：US08634704B2

    公开(公告)日：2014-01-21

    申请号：US12560869

    申请日：2009-09-16

    申请人： Robert Johnston ,  Frank Coppa ,  James Wood

    发明人： Robert Johnston ,  Frank Coppa ,  James Wood

    IPC分类号： H04N5/91 ,  H04N7/16 ,  H04N5/445 ,  G06F13/00 ,  G06F3/00

    CPC分类号： H04N5/76 ,  H04N7/17318 ,  H04N21/2747 ,  H04N21/41407 ,  H04N21/4147 ,  H04N21/4181 ,  H04N21/4333

    摘要： A system that incorporates teachings of the present disclosure may include, for example, a mobile device having a controller to present media content provided by an interactive television (iTV) network, select a function during presentation of the media content to store at least a remaining portion of the media content, wherein the function is selected when the presentation of the media content is to be interrupted, store the media content in a memory location of the mobile device, select the function to retrieve the remaining portion of the media content from the memory location, and present the remaining portion of the media content. Other embodiments are disclosed.

    摘要翻译： 结合本公开的教导的系统可以包括例如具有控制器以呈现由交互式电视（iTV）网络提供的媒体内容的移动设备，在呈现媒体内容期间选择功能以存储至少剩余的 媒体内容的一部分，其中当要中断媒体内容的呈现时选择该功能，将媒体内容存储在移动设备的存储器位置中，选择功能以从媒体内容中检索媒体内容的剩余部分 存储位置，并显示媒体内容的剩余部分。 公开了其他实施例。

    APPARATUS AND METHOD FOR PROVIDING CONTENT TO A MEDIA DEVICE
    29.
    发明申请
    APPARATUS AND METHOD FOR PROVIDING CONTENT TO A MEDIA DEVICE 有权
    提供媒体内容的装置和方法

    公开(公告)号：US20110067058A1

    公开(公告)日：2011-03-17

    申请号：US12560869

    申请日：2009-09-16

    申请人： Robert Johnston ,  Frank Coppa ,  James Wood

    发明人： Robert Johnston ,  Frank Coppa ,  James Wood

    IPC分类号： H04N5/91 ,  H04N7/16 ,  H04N5/445 ,  G06F13/00 ,  G06F3/00

    CPC分类号： H04N5/76 ,  H04N7/17318 ,  H04N21/2747 ,  H04N21/41407 ,  H04N21/4147 ,  H04N21/4181 ,  H04N21/4333

    摘要： A system that incorporates teachings of the present disclosure may include, for example, a mobile device having a controller to present media content provided by an interactive television (iTV) network, select a function during presentation of the media content to store at least a remaining portion of the media content, wherein the function is selected when the presentation of the media content is to be interrupted, store the media content in a memory location of the mobile device, select the function to retrieve the remaining portion of the media content from the memory location, and present the remaining portion of the media content. Other embodiments are disclosed.

    摘要翻译： 结合本公开的教导的系统可以包括例如具有控制器以呈现由交互式电视（iTV）网络提供的媒体内容的移动设备，在呈现媒体内容期间选择功能以存储至少剩余的 媒体内容的一部分，其中当要中断媒体内容的呈现时选择该功能，将媒体内容存储在移动设备的存储器位置中，选择功能以从媒体内容中检索媒体内容的剩余部分 存储位置，并显示媒体内容的剩余部分。 公开了其他实施例。

    Systems and methods for automatic submission, audit and adjustment of mortgage insurance claims
    30.
    发明授权
    Systems and methods for automatic submission, audit and adjustment of mortgage insurance claims 有权
    自动提交，审计和调整抵押保险索赔的制度和方法

    公开(公告)号：US07716123B2

    公开(公告)日：2010-05-11

    申请号：US10036605

    申请日：2001-12-21

    申请人： Nancy J. Dodd ,  Charla M. Parker ,  Allison N. Pope ,  Joanne A. Stewart ,  Traci L. Whitney ,  Robert Johnston

    发明人： Nancy J. Dodd ,  Charla M. Parker ,  Allison N. Pope ,  Joanne A. Stewart ,  Traci L. Whitney ,  Robert Johnston

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/02 ,  G06Q20/10 ,  G06Q40/025 ,  G06Q40/08

    摘要： Systems and methods are described for automatically processing mortgage insurance claims. In one described system, a central server computer receives inputs from, and provides outputs to, a servicer terminal connected into a network. The servicer terminal captures data from a servicer submitting a mortgage insurance claim. A claims database is connected into the network, containing data relating to the mortgage insurance claim. A claim audit rulebase is connected into the network, for automatically performing an audit and adjustment of the submitted mortgage insurance claim. The system automatically provides results of the audit and adjustment to the servicer at the servicer terminal, and presents the servicer with an option to interact with a claim representative to resolve any issues.

    摘要翻译： 描述了系统和方法，用于自动处理抵押保险索赔。 在一个描述的系统中，中央服务器计算机从连接到网络的服务器终端接收输入，并向其提供输出。 服务机构终端从提交抵押保险索赔的服务机构中获取数据。 索赔数据库连接到网络中，包含与抵押保险索赔相关的数据。 索赔审计规则库连接到网络中，用于自动执行提交的抵押保险索赔的审计和调整。 系统会自动向服务人员终端提供审核和调整结果，并向服务人员介绍与索赔代表进行交互以解决任何问题的选项。