公开(公告)号：US20210179607A1

公开(公告)日：2021-06-17

申请号：US16758717

申请日：2018-10-29

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongqi Deng ,  Abdelghani Achab ,  Bridget A. Becker ,  David Jonathan Bennett ,  Indu Bharathan ,  Xavier Fradera ,  Craig Gibeau ,  Yongxin Han ,  Derun Li ,  Kun Liu ,  Qinglin Pu ,  Sulagna Sanyal ,  David Sloman ,  Wensheng Yu ,  Hongjun Zhang

IPC: C07D471/04 ,  C07D215/14 ,  A61K45/06

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20210161896A1

公开(公告)日：2021-06-03

申请号：US17267866

申请日：2019-08-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Dane Clausen ,  Xavier Fradera ,  Yongxin Han ,  Alexander Pasternak ,  Li Xiao ,  Hongjun Zhang

IPC: A61K31/506 ,  A61K45/06 ,  C07D215/20 ,  C07D401/12 ,  C07D401/04 ,  A61K31/47 ,  A61K31/4709

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20180362482A1

公开(公告)日：2018-12-20

申请号：US16061597

申请日：2016-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Purakkattle Biju ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Kurukulasuriya ,  Kun Liu ,  Meredeth Ann McGowan ,  Qinglin Pu ,  Nunzio Sciammetta ,  Hongjun Zhang ,  Hua Zhou

IPC: C07D271/08 ,  C07D285/10 ,  C07D413/12 ,  A61P25/24 ,  A61P25/28 ,  A61P35/02 ,  A61P31/14 ,  A61P27/12 ,  A61P37/06

CPC classification number: C07D271/08 ,  A61P25/24 ,  A61P25/28 ,  A61P27/12 ,  A61P31/14 ,  A61P35/02 ,  A61P37/06 ,  C07D285/10 ,  C07D413/12 ,  C07D417/12 ,  C07F9/65318

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11498904B2

公开(公告)日：2022-11-15

申请号：US16761855

申请日：2018-11-09

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Indu Bharathan ,  Xavier Fradera ,  Derun Li ,  Nunzio Sciammetta ,  Wensheng Yu

IPC: C07D241/12 ,  A61K45/06 ,  C07D213/56 ,  C07D213/64 ,  C07D213/76 ,  C07D237/08 ,  C07D239/26 ,  C07D241/18 ,  C07D401/04 ,  C07D405/10 ,  C07D413/04

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11478461B2

公开(公告)日：2022-10-25

申请号：US17047247

申请日：2019-04-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： Liangqin Guo ,  Hongjun Zhang ,  Ping Chen ,  Dane Clausen ,  Xavier Fradera ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Alexander Pasternak ,  Qinglin Pu ,  Li Xiao ,  Feng Ye

IPC: A61K31/44 ,  A61K45/06 ,  C07C237/22 ,  C07C255/60 ,  C07D213/75 ,  C07C271/36 ,  C07C233/78 ,  C07C271/24 ,  C07C233/79 ,  C07D213/81 ,  C07D271/06 ,  C07D239/28 ,  C07D215/48 ,  C07C275/30 ,  C07C275/28 ,  C07D239/42 ,  C07D305/06 ,  C07D261/08 ,  C07D471/04 ,  C07D261/20 ,  C07D209/34 ,  C07D277/56 ,  C07D217/02 ,  C07D231/14 ,  C07D237/28 ,  C07D241/24 ,  C07D217/26 ,  A61K31/167 ,  A61K31/27 ,  A61K31/4245 ,  A61K31/47 ,  A61K31/17 ,  A61K31/505 ,  A61K31/337 ,  A61K31/437 ,  A61K31/42 ,  A61K31/426 ,  A61K31/472 ,  A61K31/415 ,  A61K31/4965

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11179389B2

公开(公告)日：2021-11-23

申请号：US16764107

申请日：2018-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Meredeth A. McGowan ,  Jason D. Katz ,  Hua Zhou ,  David James Witter ,  Chaomin Li ,  Kathryn A. Lipford ,  Joey L. Methot ,  Abdelghani A. Achab ,  Xavier Fradera ,  Shimin Xu ,  Jianmin Fu

IPC: A61K31/497 ,  C07D471/10 ,  C07D498/10 ,  C07D403/14 ,  C07D401/14 ,  C07D413/14 ,  A61K31/5386 ,  A61K31/5377 ,  C07D491/107

Abstract: The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

公开(公告)号：US20200290996A1

公开(公告)日：2020-09-17

申请号：US16753050

申请日：2018-10-04

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Catherine M. White ,  Abdelghani Achab ,  Indu T. Bharathan ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Jongwon Lim ,  Kun Liu ,  Meredeth Ann McGowan ,  Nunzio Sciammetta ,  Wensheng Yu ,  Hongjun Zhang ,  Hua Zhou

IPC: C07D401/14 ,  C07D401/12 ,  C07D213/74 ,  C07D405/12 ,  C07D413/14 ,  C07D417/14

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20200216425A1

公开(公告)日：2020-07-09

申请号：US16819325

申请日：2020-03-16

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Yongqi Deng ,  Xavier Fradera ,  Craig Gibeau ,  Brett A. Hopkins ,  Derun Li ,  Kun Liu ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  David Sloman ,  Catherine White ,  Hongjun Zhang ,  Hua Zhou

IPC: C07D405/10 ,  A61K31/4427 ,  A61K31/4965 ,  C07D241/12 ,  A61K31/501 ,  C07D417/14 ,  A61K31/4418 ,  C07D213/56 ,  C07D401/04 ,  C07D413/04 ,  A61K31/513 ,  A61K31/444 ,  C07D405/14 ,  A61K31/4184 ,  A61K31/4245 ,  A61K31/41 ,  A61K31/427 ,  C07D417/10 ,  A61K31/337 ,  C07D305/08 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/437 ,  C07D471/04 ,  A61K45/06 ,  A61K31/4523 ,  C07D413/14 ,  C07D209/46 ,  A61P31/00 ,  C07D405/04 ,  C07D401/12 ,  C07D413/10 ,  A61P35/00 ,  C07D231/12 ,  A61P37/00 ,  C07D263/32

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US20190144433A1

公开(公告)日：2019-05-16

申请号：US16186769

申请日：2018-11-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Yongqi Deng ,  Xavier Fradera ,  Craig Gibeau ,  Brett A. Hopkins ,  Derun Li ,  Kun Liu ,  Meredeth A. McGowan ,  Nunzio Sciammetta ,  David Sloman ,  Catherine White ,  Hongjun Zhang ,  Hua Zhou

IPC: C07D405/10 ,  A61K31/4427 ,  A61K45/06 ,  C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/4155 ,  C07D305/08 ,  A61K31/337 ,  C07D417/10 ,  A61K31/427 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/4184 ,  C07D405/14 ,  A61K31/444 ,  A61K31/513 ,  C07D413/04 ,  C07D401/04 ,  C07D213/56 ,  A61K31/4418 ,  C07D417/14 ,  A61K31/501 ,  C07D241/12 ,  A61K31/4965 ,  A61K31/4523

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.