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公开(公告)号：US20190365727A1
公开(公告)日：2019-12-05
申请号：US16479997
申请日：2018-01-23
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Tao Yu , John A. McCauley , Alan Whitehead , James M. Apgar , Izzat T. Raheem , Guizhen Dong , Sherman T. Waddell , Hong Li
IPC: A61K31/4375 , C07D491/147 , A61K31/5365 , A61K31/506 , A61K31/7068 , A61K31/7076 , A61K31/427 , A61K31/4402 , A61K31/675 , A61K31/47
Abstract: The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1 is as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US20180325927A1
公开(公告)日：2018-11-15
申请号：US15775966
申请日：2016-11-11
Applicant: Merck Sharp & Dohme Corp.
Inventor： Thomas H. Graham , Tao Yu , Sherman T. Waddell , John A. McCauley , Andrew Stamford , Wengsheng Liu , Jay A. Grobler , Libo Xu
IPC: A61K31/675 , A61K31/683 , A61P31/18
CPC classification number: A61K31/675 , A61K31/34 , A61K31/426 , A61K31/44 , A61K31/513 , A61K31/52 , A61K31/535 , A61K31/683 , A61K31/7068 , A61K45/06 , A61K2300/00 , A61P31/18 , C07D471/04 , C07F9/6561
Abstract: The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R1, R2 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyridotriazine Derivative, and methods of using the Amido-Substituted Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.
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公开(公告)号：US09840478B2
公开(公告)日：2017-12-12
申请号：US14908421
申请日：2014-07-29
Applicant: MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD.
Inventor： Peter D. Williams , John A. McCauley , David Jonathan Bennett , Christopher J. Bungard , Lehua Chang , Michael P. Dwyer , M. Katharine Holloway , Kartik M. Keertikar , H. Marie Loughran , Jessie J. Manikowski , Gregori J. Morriello , Dong-Ming Shen , Edward C. Sherer , Jurgen Schultz , Sherman T. Waddell , Catherine M. Wiscount , Nicolas Zorn , Xin-Jie Chu , Satyanarayana Tummanapalli , Vijayasaradhi Sivalenka , Bin Hu , Tao Ji , Bin Zhong
IPC: C07D241/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/14
CPC classification number: C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
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公开(公告)号：US20170073354A1
公开(公告)日：2017-03-16
申请号：US15124635
申请日：2015-03-06
Applicant: Jurgen SCHULZ , Peter D. WILLIAMS , John A. MCCAULEY , Christopher J. BUNGARD , David Jonathan BENNETT , Sherman T. WADDELL , Gregori J. MORRIELLO , Lehua CHANG , Michael P. DWYER , Katharine M. HOLLOWAY , Alejandro CRESPO , Xin-Jie CHU , Catherine WISCOUNT , Marie H. LOUGHRAN , Jesse J. MANIKOWSKI , Kartik M. KEERTIKAR , Bin HU , Bin ZHONG , Tao JI , Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
Inventor： Peter D. Williams , John A. McCauley , Christopher J. Bungard , David Jonathan Bennett , Sherman T. Waddell , Gregori J. Morriello , Lehua Chang , Michael P. Dwyer , M. Katharine Holloway , Alejandro Crespo , Xin-Jie Chu , Catherine Wiscount , H. Marie Loughran , Jesse J. Manikowski , Jurgen Schulz , Kartik M. Keertikar , Bin Hu , Bin Zhong , Tao Ji
IPC: C07D513/08 , A61K31/554 , A61K45/06
CPC classification number: C07D513/08 , A61K31/554 , A61K45/06
Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
Abstract translation: 本发明涉及含有该化合物的式I药物组合物的化合物及其在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，HIV感染治疗和预防， 治疗和延迟艾滋病的发病或进展。
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公开(公告)号：US20160159752A1
公开(公告)日：2016-06-09
申请号：US14908421
申请日：2014-07-29
Applicant: MERCK SHARP & DOHME CORP. , MSD R&D (CHINA) CO., LTD.
Inventor： Peter D. Williams , John A. McCauley , David Jonathan Bennett , Christopher J. Bungard , Lehua Chang , Michael P. Dwyer , M. Katharine Holloway , Kartik M. Keertikar , H. Marie Loughran , Jessie J. Manikowski , Gregori J. Morriello , Dong-Ming Shen , Edward C. Sherer , Jurgen Schultz , Sherman T. Waddell , Catherine M. Wiscount , Nicolas Zorn , Xin-Jie Chu , Satyanarayana Tummanapalli , Vijayasaradhi Sivalenka , Bin Hu , Tao Ji , Bin Zhong
IPC: C07D241/04 , C07D401/12 , C07D417/14 , C07D405/14 , C07D413/14 , C07D401/06 , C07D405/12
CPC classification number: C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
Abstract translation: 本发明涉及哌嗪衍生物，包含它们的药物组合物及其在抑制HIV蛋白酶，HIV复制抑制，HIV预防感染，HIV感染治疗和预防治疗中的用途 ，并延迟艾滋病的发病或进展。
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Patent Agency Ranking
公开(公告)号：US20160009682A1
公开(公告)日：2016-01-14
申请号：US14772589
申请日：2014-02-27
Applicant: MERCK SHARP & DOHME CORP.
Inventor： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Joel M. Harris , Bernard Neustadt , Andrew Stamford , Marc Poirier , John A. McCauley , Thomas Greshock , Heather Stevenson , John Sanders , Jonathan Kern
IPC: C07D401/04 , C07D491/113 , C07D413/14 , C07D405/14 , C07D487/10 , C07D487/04 , C07D471/10 , C07D491/04 , C07D409/14 , C07D417/14 , C07D498/04 , C07D498/08 , C07D451/02 , C07D491/107 , C07D491/08 , C07D491/056 , C07D401/14
CPC classification number: C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/056 , C07D491/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D498/04 , C07D498/08
Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
Abstract translation: 本发明涉及作为LRRK2激酶的有效抑制剂的吲唑化合物，可用于治疗或预防其中涉及LRRK2激酶的疾病，例如帕金森病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK-2激酶的疾病中的用途。
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公开(公告)号：US11358711B2
公开(公告)日：2022-06-14
申请号：US17025371
申请日：2020-09-18
Applicant: Merck Sharp & Dohme Corp.
Inventor： Thomas H. Graham , Tao Yu , Yonglian Zhang , John A. McCauley
IPC: A61K31/5365 , B64C27/48 , B64C11/08 , A61P31/18 , A61K31/18 , A61K31/407 , A61K31/4188 , A61K31/4439 , A61K31/4985 , A61K31/519 , A61K31/553 , A61K31/7076 , C07D498/16 , C07D498/22 , C12N15/113
Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and Ware as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US20210115044A1
公开(公告)日：2021-04-22
申请号：US17048811
申请日：2019-04-22
Applicant: Merck Sharp & Dohme Corp.
Inventor： Tao Yu , James M. Apgar , Alan Whitehead , Yonglian Zhang , Zhiyong Hu , Valerie W. Shurtleff , John A. McCauley , Izzat T. Raheem
IPC: C07D471/16 , A61K31/4985 , A61P31/18 , A61K31/52 , A61K31/435 , A61K31/5383 , A61K31/506 , A61K31/513 , A61K31/685 , A61K31/427
Abstract: The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US20210040096A1
公开(公告)日：2021-02-11
申请号：US17081094
申请日：2020-10-27
Applicant: Merck Sharp & Dohme Corp.
Inventor： Tao Yu , Sherman T. Waddell , Thomas H. Graham , Yonglian Zhang , John A. McCauley , Andrew W. Stamford , Jiaqiang Cai , Zhiqi Qi
IPC: C07D471/16 , A61K31/52 , A61K31/505 , A61K31/513 , A61K31/635 , A61K31/4985 , A61K31/427 , A61K31/5365 , A61K31/4402 , A61K31/683
Abstract: The present invention relates to Fused Tricyclic Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocyclic Compound, and methods of using the Fused Tricyclic Heterocyclic Compounds for treating or preventing HIV infection in a subject.
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公开(公告)号：US20210009262A1
公开(公告)日：2021-01-14
申请号：US17025371
申请日：2020-09-18
Applicant: Merck Sharp & Dohme Corp.
Inventor： Thomas H. Graham , Tao Yu , Yonglian Zhang , John A. McCauley
Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and Ware as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
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