公开(公告)号：US20050136058A1

公开(公告)日：2005-06-23

申请号：US11056824

申请日：2005-02-11

Applicant: Michael Kiefer

Inventor： Michael Kiefer

IPC: A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  A61K39/395 ,  A61K38/22 ,  C07K14/565 ,  C07K16/26

CPC classification number: C07K14/4743 ,  A01K2217/05 ,  A61K38/00 ,  C07K16/18

Abstract: A purified insulin-like growth factor binding protein (IGFBP) selected from the group consisting of insulin-like growth factor binding protein having an amino acid sequence that, preferably, is at least 70% homologous to the amino acid sequence of FIG. 1 and fragments thereof that are capable of binding to an antibody specific for the protein or to an insulin-like growth factor is described. This new IGFBP is designated herein as IGFBP-6. Recombinant DNA molecules encoding the binding proteins and subsequences thereof are also described along with recombinant microorganisms and cell lines containing the DNA molecules and methods for producing the binding proteins using recombinant hosts containing the relevant DNA molecules. Antibodies to the protein, useful in various diagnostic applications, are also described.

公开(公告)号：US06879900B2

公开(公告)日：2005-04-12

申请号：US10415038

申请日：2001-11-07

Applicant: Markus Henneken ,  Friedemann Jauch ,  Franz-Josef Schuler ,  Thomas Mauz ,  Michael Kiefer

Inventor： Markus Henneken ,  Friedemann Jauch ,  Franz-Josef Schuler ,  Thomas Mauz ,  Michael Kiefer

IPC: F16H61/02 ,  F16H59/14 ,  F16H59/48 ,  F16H61/16

CPC classification number: F16H61/16 ,  B60W2510/0657 ,  F16H59/141 ,  F16H59/48 ,  F16H2059/142 ,  F16H2059/144 ,  F16H2059/183 ,  F16H2061/163 ,  Y10T477/688 ,  Y10T477/692

Abstract: A method for controlling an automatic transmission of a motor vehicle in the event of a spontaneous gas/pedal release (FastOff). The automatic transmission is driven by an internal combustion engine which can be influenced by an accelerator pedal and a signal proportional to a pedal position is fed to an electronic transmission control in which shifting characteristic field is stored and the spontaneous gas/pedal release (FastOff) is detected and an upshift block (FFO=1) is activated when a pedal position gradient (PSTG) falls below a pedal gradient threshold (KF_PSTG). The mode of the upshift block (FFO=1) is removed when a traction operation is detected when an actual engine torque (MMM) exceeds a push-pull line (KL_ZS) stored as a function of a value equivalent to an engine rotational speed (NMO) in dependence on a vehicle acceleration/deceleration (AIST) dependent on an overall tractional resistance (GFW) and pedal gradient thresholds (KW_PSTGPOS, KW_PSTGNEG).

Abstract translation: 在自发气体/踏板释放（FastOff）的情况下控制机动车辆的自动变速器的方法。 自动变速器由内燃机驱动，该内燃机可受加速器踏板影响，与踏板位置成正比的信号被送入其中存储换挡特性场的电子变速器控制和自发气/踏板释放（FastOff） 并且当踏板位置梯度（PSTG）降到踏板坡度阈值（KF_PSTG）以下时，升档块（FFO = 1）被激活。 当实际发动机扭矩（MMM）超过作为与发动机转速相当的值的函数存储的推挽线（KL_ZS）时，当检测到牵引操作时，升档块（FFO = 1）的模式被移除 NMO），其依赖于取决于总体阻力（GFW）和踏板梯度阈值（KW_PSTGPOS，KW_PSTGNEG）的车辆加速/减速（AIST）。

公开(公告)号：US09043104B2

公开(公告)日：2015-05-26

申请号：US13577283

申请日：2010-12-14

Applicant: Michael Kiefer ,  Franz-Josef Schuler ,  Uwe Reitemeier ,  Andreas Maus

Inventor： Michael Kiefer ,  Franz-Josef Schuler ,  Uwe Reitemeier ,  Andreas Maus

IPC: F16H61/02 ,  F16H59/66 ,  F16H61/21 ,  F16H59/00

CPC classification number: F16H61/0213 ,  F16H59/66 ,  F16H61/21 ,  F16H2059/003 ,  F16H2059/666

Abstract: A method of determining and shifting to an optimal gear in a vehicle prior to entering a curve in a vehicle which comprises an automatic transmission. A curve speed limit is determined for an anticipated curve which is recognized by a navigation device, an anticipated road pattern and dependent on the vehicle and curve or road data, and a sportiness indicator (Ftyp). For each anticipated curve, an actual, optimal gear is determined, based on the determined curve speed limit and the sportiness indicator (FTyp) and, after determining the optimal gear, the method performs a check to determine whether or not the optimal gear deviates from the engaged gear (RGA_DEST). When a deviation is recognized and a driver reaction, which causes a deceleration of the vehicle and/or a reduction of the vehicle speed, is present, a down shift down to the actual, optimal gear occurs.

Abstract translation: 一种在包括自动变速器的车辆中进入曲线之前确定和转换到车辆中的最佳档位的方法。 对于由导航装置识别的预期曲线，预期道路图案，并且取决于车辆和曲线或道路数据，以及运动指示符（Ftyp），确定曲线速度限制。 对于每个预期曲线，基于确定的曲线速度限制和运动指示器（FTyp）确定实际的最佳档位，并且在确定最佳档位之后，该方法执行检查以确定最佳档位是否偏离 啮合齿轮（RGA_DEST）。 当存在偏差并且存在导致车辆减速和/或车速降低的驾驶员反应时，发生向下移动到实际的最佳档位。

公开(公告)号：US20110222960A1

公开(公告)日：2011-09-15

申请号：US12998612

申请日：2009-03-27

Applicant: Michael Kiefer

Inventor： Michael Kiefer

IPC: E04H15/32 ,  F16C11/06

CPC classification number: F16C11/0623 ,  E04H15/58 ,  Y10T403/32 ,  Y10T403/32631

Abstract: A load-absorbing device for initiating load forces such as cable forces or tensioning forces of sheet-like structures into supporting structures (10), with at least one bearing element (24, 80) which is anchored on the respective supporting structure (10) and to which a tie rod (40) of a load-absorbing part (36, 40) is connected, and with a connection device (50) for tension members (16; 98) which cooperates with the tie bar (40), is characterized in that the connection device (50) has at least one connection wing (66) which projects laterally from the longitudinal axis (A) and which forms at least one connection point (69a) offset with respect to the longitudinal axis (A).

Abstract translation: 一种负载吸收装置，用于将至少一个锚固在相应的支撑结构（10）上的至少一个轴承元件（24,80）起始，将片状结构的拉力或拉伸力的载荷力引入支撑结构（10） 连接有负载吸收部分（36,40）的拉杆（40），以及与拉杆（40）配合的用于张紧构件（16; 98）的连接装置（50），是连接装置 其特征在于，所述连接装置（50）具有至少一个连接翼（66），所述至少一个连接翼（66）从所述纵向轴线（A）横向突出并且形成相对于所述纵向轴线（A）偏移的至少一个连接点（69a）。

公开(公告)号：US20110180366A1

公开(公告)日：2011-07-28

申请号：US13122164

申请日：2009-08-19

Applicant: Servet Yildiz ,  Michael Kiefer ,  Axel Geiberger

Inventor： Servet Yildiz ,  Michael Kiefer ,  Axel Geiberger

IPC: F16D13/60 ,  B23P11/00

CPC classification number: F16D13/70 ,  F16D21/06 ,  F16D2300/12 ,  F16D2300/26 ,  Y10T29/49826

Abstract: A disc component of a clutch assembly includes, but is not limited to, one or more mounting structures. One of the mounting structures opens in a longitudinal direction of the disc component. The mounting structure is configured to receive a pre-mounted fastener on a second disc component of the clutch assembly from the longitudinal direction. The pre-mounted fastener is configured to fasten the disc component to the second component of from a lateral side of the disc component.

Abstract translation: 离合器组件的盘部件包括但不限于一个或多个安装结构。 一个安装结构在盘部件的纵向方向上开口。 安装结构被配置为从纵向方向接收在离合器组件的第二盘部件上的预先安装的紧固件。 预先安装的紧固件构造成将盘部件从盘部件的侧面紧固到第二部件。

公开(公告)号：US07972244B2

公开(公告)日：2011-07-05

申请号：US11913982

申请日：2006-04-26

Applicant: Armin Gierling ,  Friedemann Jauch ,  Franz-Josef Schuler ,  Michael Kiefer

Inventor： Armin Gierling ,  Friedemann Jauch ,  Franz-Josef Schuler ,  Michael Kiefer

IPC: F16H61/26

CPC classification number: F16H61/16 ,  F16H61/0213 ,  F16H2061/163 ,  Y10T477/65 ,  Y10T477/6936 ,  Y10T477/69363

Abstract: Described is a method for controlling a transmission for motor vehicles, especially an automatic transmission or an automatic gearbox, where a gear ratio (“1”, “2”, “3”, “4”, “5”, “6”) is adjusted according to operating conditions by means of pre-determined shifting programs (“0”, “Eco”, “Normal”, “Sport”, “Mountain II”, “Warm-up”, “Tip”) and corresponding specific shifting values (HS45, RS43) and where in relation to a vehicle's actual operating condition at least one special function (“Curve Recognition KE”, “Rapid Drive Pedal Release FO”, “Spontaneous Delay Vehicle SVF”, “Drive Speed Control FGR”, “Drive Dynamic control ESP”) is activated, which prevents the change from an actual gear ratio to a target gear ratio requested by a shifting program within a pre-determined operating range of a vehicle. In a first version of the method, the operating range, wherein a gear ratio change of the transmission is prevented, is changed in relation to applied specific values that depend on the operating condition. In a second version of the method it is planned that the shifting characteristics are changed in relation to applied specific values that depend on the operating condition in such a manner that the operating points of the vehicle that are defined on the side of the shift characteristics, for which gear ratio changes must be performed, are adjusted to the actual operating condition of the vehicle.

Abstract translation: 描述了一种用于控制机动车辆，特别是自动变速器或自动变速箱的变速器的方法，其中齿轮比（“1”，“2”，“3”，“4”，“5”，“6”） （“0”，“Eco”，“Normal”，“Sport”，“Mountain II”，“暖身”，“Tip”）和相应的特定位移 值（HS45，RS43）以及车辆的实际运行状况至少一个特殊功能（“曲线识别KE”，“快速驱动踏板释放FO”，“自发延迟车SVF”，“驱动速度控制FGR” “驱动动态控制ESP”）被激活，这防止了在车辆的预定操作范围内由变速程序请求的实际齿轮比与目标传动比的变化。 在该方法的第一版本中，防止变速器的变速比变化的操作范围相对于取决于运行状态的所应用的特定值而改变。 在该方法的第二版本中，计划移动特性相对于依赖于操作条件的应用的特定值而改变，使得在换档特性侧限定的车辆的操作点， 必须对其进行变速比的变更，调整到车辆的实际运行状态。

公开(公告)号：US20080305927A1

公开(公告)日：2008-12-11

申请号：US11913982

申请日：2006-04-26

Applicant: Armin Gierling ,  Friedermann Jauch ,  Franz-Josef Schuler ,  Michael Kiefer

Inventor： Armin Gierling ,  Friedermann Jauch ,  Franz-Josef Schuler ,  Michael Kiefer

IPC: F16H61/16 ,  F16H61/02

CPC classification number: F16H61/16 ,  F16H61/0213 ,  F16H2061/163 ,  Y10T477/65 ,  Y10T477/6936 ,  Y10T477/69363

Abstract: Described is a method for controlling a transmission for motor vehicles, especially an automatic transmission or an automatic gearbox, where a gear ratio (“1”, “2”, “3”, “4”, “5”, “6”) is adjusted according to operating conditions by means of pre-determined shifting programs (“0”, “Eco”, “Normal”, “Sport”, “Mountain II”, “Warm-up”, “Tip”) and corresponding specific shifting values (HS45, RS43) and where in relation to a vehicle's actual operating condition at least one special function (“Curve Recognition KE”, “Rapid Drive Pedal Release FO”, “Spontaneous Delay Vehicle SVF”, “Drive Speed Control FGR”, “Drive Dynamic control ESP”) is activated, which prevents the change from an actual gear ratio to a target gear ratio requested by a shifting program within a pre-determined operating range of a vehicle. In a first version of the method, the operating range, wherein a gear ratio change of the transmission is prevented, is changed in relation to applied specific values that depend on the operating condition. In a second version of the method it is planned that the shifting characteristics are changed in relation to applied specific values that depend on the operating condition in such a manner that the operating points of the vehicle that are defined on the side of the shift characteristics, for which gear ratio changes must be performed, are adjusted to the actual operating condition of the vehicle.

Abstract translation: 描述了一种用于控制机动车辆，特别是自动变速器或自动变速箱的变速器的方法，其中齿轮比（“1”，“2”，“3”，“4”，“5”，“6”） （“0”，“Eco”，“Normal”，“Sport”，“Mountain II”，“暖身”，“Tip”）和相应的特定位移 值（HS45，RS43）以及车辆的实际运行状况至少一个特殊功能（“曲线识别KE”，“快速驱动踏板释放FO”，“自发延迟车SVF”，“驱动速度控制FGR” “驱动动态控制ESP”）被激活，这防止了在车辆的预定操作范围内由变速程序请求的实际齿轮比与目标传动比的变化。 在该方法的第一版本中，防止变速器的变速比变化的操作范围相对于取决于运行状态的所应用的特定值而改变。 在该方法的第二版本中，计划移动特性相对于依赖于操作条件的应用的特定值而改变，使得在换档特性侧限定的车辆的操作点， 必须对其进行变速比的变更，调整到车辆的实际运行状态。

公开(公告)号：US20070099215A1

公开(公告)日：2007-05-03

申请号：US11539859

申请日：2006-10-09

Applicant: Michael Kiefer ,  Paul Fitzpatrick ,  Helen Gibson ,  Philip Barr

Inventor： Michael Kiefer ,  Paul Fitzpatrick ,  Helen Gibson ,  Philip Barr

IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  G01N2333/47 ,  G01N2500/02 ,  G01N2510/00

Abstract: The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.

Abstract translation: 本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。 本发明还提供了结合Bak的BBP。 本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。 本发明还提供了特异性结合BBP的抗体。 本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。 本发明还提供了用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。 本发明另外包括称为“BBP结合域”的新肽，以及涉及Bak和BBP之间的相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。

公开(公告)号：US07001308B2

公开(公告)日：2006-02-21

申请号：US10478356

申请日：2002-05-18

Applicant: Markus Henneken ,  Friedemann Jauch ,  Franz-Josef Schuler ,  Thomas Mauz ,  Michael Kiefer

Inventor： Markus Henneken ,  Friedemann Jauch ,  Franz-Josef Schuler ,  Thomas Mauz ,  Michael Kiefer

IPC: F16H59/30

CPC classification number: F16H59/0204 ,  F16H59/18 ,  F16H61/16 ,  F16H2059/0239 ,  F16H2059/0243 ,  Y10T74/19251 ,  Y10T74/2003 ,  Y10T74/20067 ,  Y10T74/20159 ,  Y10T477/693 ,  Y10T477/6933 ,  Y10T477/6934

Abstract: A shift device for an automatic transmission of a vehicle, particularly of a motor vehicle, is proposed in which the request to change the current ratio of the automatic transmission upon reaching preset operating states of the vehicle can be automatically generated or by manual input in a manual shifting mode. A pulse counter is here provided by way of successive pulses and manual input can be functionally interlinked wherein a shift signal can be generated depending on the linkage.

Abstract translation: 提出了一种用于车辆，特别是机动车辆的自动变速器的换档装置，其中可以自动生成在达到车辆的预设操作状态时改变自动变速器的当前比率的请求，或者通过手动输入 手动切换模式。 这里通过连续脉冲提供脉冲计数器，并且手动输入可以在功能上互连，其中可以根据联动产生移位信号。

公开(公告)号：US08602368B2

公开(公告)日：2013-12-10

申请号：US12998613

申请日：2009-03-27

Applicant: Michael Kiefer

Inventor： Michael Kiefer

IPC: F16M11/02

CPC classification number: F16C11/0623 ,  E04H15/58 ,  Y10T403/32 ,  Y10T403/32631

Abstract: A load-absorbing device for introducing load forces, in particular cable forces in support devices for tent-shaped coverings and the like, has at least one load-absorbing part (9) on a supporting structure (7). The load-absorbing part (9) is provided on a transmission body (17) forming on at least part of its outer surface, a convex transmission surface (21) which transmits the load forces and which is guided on the supporting structure (7) on carrier surface formed from concave surface parts adapted to the convexity of the transmission surface (21). A load-absorbing node is formed allowing a ball joint-like mobility of the load absorbing part (9) relative to the supporting structure (7).

Abstract translation: 用于引入负载力的负载吸收装置，特别是用于帐篷形覆盖物等的支撑装置中的电缆力在支撑结构（7）上具有至少一个负载吸收部分（9）。 负载吸收部（9）设置在形成在其外表面的至少一部分上的变速体（17）上，传递负载力并在支撑结构（7）上被引导的凸形传动面（21） 在由适于透射表面（21）的凸起的凹面部分形成的载体表面上。 形成负载吸收节点，使负载吸收部（9）相对于支撑结构（7）的球状接头移动。