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公开(公告)号：US08109927B2
公开(公告)日：2012-02-07
申请号：US12833843
申请日：2010-07-09
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译： 提供用于烧伤组织的表面电极。 所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。 针电极的可调性允许针电极穿透组织的深度被调整。
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公开(公告)号：US07182761B2
公开(公告)日：2007-02-27
申请号：US10734648
申请日：2003-12-11
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B18/148 , A61B2017/00867 , A61B2018/00577 , A61B2018/143 , A61B2018/1432 , C08L2201/12
摘要： A medical probe assembly and method are provided for ablating tissue. The probe assembly comprises an elongated shaft and an electrode array mechanically coupled to the distal end of the shaft. The electrode array is configured to assume an outwardly curved shape, when exposed to a first temperature, and assume a pointed tip when exposed to a second temperature less than the first temperature. The first temperature is preferably greater than body temperature, e.g., equal to the tissue ablation temperature, and the second temperature is preferably less than a tissue ablation temperature, e.g., body temperature. In this manner, the pointed tip assumed by the electrode array facilitates introduction of the probe assembly through the tissue prior to the ablation process, while the outwardly curved shape assumed by the electrode array facilitates deployment of the electrode array within the tissue during the ablation process. The exposed needle electrodes also facilitate the visualization of the probe assembly under fluoroscopy. The probe assembly comprises an optional deployment member, which is configured to linearly expand when exposed to a third temperature, thereby displacing the electrode array.
摘要翻译： 提供了用于烧蚀组织的医疗探针组件和方法。 探针组件包括细长轴和机械耦合到轴的远端的电极阵列。 当暴露于第一温度时，电极阵列构造成呈现向外弯曲的形状，并且当暴露于小于第一温度的第二温度时呈现尖端尖端。 第一温度优选地大于体温，例如等于组织消融温度，并且第二温度优选小于组织消融温度，例如体温。 以这种方式，由电极阵列假设的尖端有助于在消融过程之前通过组织引入探针组件，而由电极阵列假设的向外弯曲的形状有助于在消融过程期间电极阵列在组织内的展开 。 暴露的针电极还有助于荧光检查下探针组件的可视化。 探针组件包括可选的展开构件，其构造成当暴露于第三温度时线性膨胀，从而移位电极阵列。
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公开(公告)号：US07101387B2
公开(公告)日：2006-09-05
申请号：US10426360
申请日：2003-04-30
CPC分类号： A61B18/1477 , A61B18/14 , A61B90/04 , A61B2018/00005 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00577 , A61B2090/0445 , A61B2090/0481
摘要： A medical assembly and method are provided to effectively treat abnormal tissue, such as, a tumor. The target tissue is thermally ablated using a suitable source, such as RF or laser energy. A cooling shield is placed in contact with non-target tissue adjacent the target tissue, and actively cooled to conduct thermal energy away from the non-target tissue. In one method, the cooling shield can be placed between two organs, in which case, one of the two organs can comprise the target tissue, and the other of the two organs can comprise the non-target tissue. In this case, the cooling shield may comprise an actively cooled inflatable balloon, which can be disposed between the two organs when deflated, and then inflated. The inflatable balloon can be actively cooled by pumping a cooling medium through it. In another method, the cooling shield can be embedded within the non-target tissue. In this case, the cooling shield can comprise one or more needles. If a plurality of needles is used, they can be embedded into the non-target tissue in a series, e.g., a rectilinear or curvilinear arrangement. The needle(s) can be actively cooled by pumping a cooling medium through them.
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公开(公告)号：US06974455B2
公开(公告)日：2005-12-13
申请号：US10121113
申请日：2002-04-10
CPC分类号： A61B18/1482 , A61B90/50 , A61B2018/1467 , A61B2018/1475 , A61N1/06
摘要： A system for ablating lesions in the interior regions of the human body including a RF catheter and a control system adapted to facilitate the automatic step deployment of an array-type energy delivery system positioned within the catheter. The RF catheter and control system further include an auto array deployment mechanism coupled to the array-type energy delivery system and an impedance and temperature monitoring system. In addition, the system includes a probe positioning device adapted to maintain a RF probe in a desired orientation during ablation procedures.
摘要翻译： 一种用于消除人体内部区域中的损伤的系统，包括RF导管和适于便于定位在导管内的阵列型能量输送系统的自动步骤部署的控制系统。 RF导管和控制系统还包括耦合到阵列型能量输送系统的自动阵列展开机构和阻抗和温度监测系统。 此外，该系统包括探针定位装置，其适于在消融过程期间将RF探针保持在期望的取向。
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公开(公告)号：US06918907B2
公开(公告)日：2005-07-19
申请号：US10388143
申请日：2003-03-13
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译： 提供用于烧伤组织的表面电极。 所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。 针电极的可调性允许针电极穿透组织的深度被调整。
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公开(公告)号：US06508805B1
公开(公告)日：2003-01-21
申请号：US09684819
申请日：2000-10-10
申请人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
发明人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
IPC分类号： A61M2500
CPC分类号： A61M25/005 , A61M25/0053
摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.
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公开(公告)号：US08641709B2
公开(公告)日：2014-02-04
申请号：US12685139
申请日：2010-01-11
IPC分类号： A61B18/14
CPC分类号： A61B17/12036 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B18/1477 , A61B18/1485 , A61B2017/00557 , A61B2017/22067 , A61B2018/00214 , A61B2018/00577
摘要： Methods and devices for occluding a vessel during a percutaneous ablation procedure. An elongated access device having a lumen and a tissue piercing, open distal end in communication with the lumen is used to percutaneously access a vessel that supplied blood to the tissue to be treated. An elongated balloon deployment device is used to deliver a balloon into the interior of the vessel. The balloon is inflated, resulting in the occlusion of the vessel. The tissue to be treated is ablated. Because there is little or no blood to transfer the thermal energy away from the heated tissue, the ablation procedure is performed more efficiently. The balloon may be subsequently deflated allowing normal flow through the vessel to return.
摘要翻译： 在经皮消融手术期间闭塞血管的方法和装置。 使用具有内腔和与内腔连通的组织刺穿的开放远端的细长的进入装置来经皮地进入供应待处理组织的血液的血管。 使用细长的气囊展开装置将气囊输送到容器的内部。 气球膨胀，导致血管闭塞。 要治疗的组织被消融。 因为很少或没有血液将热能转移到加热的组织之外，因此更有效地进行消融过程。 气球可能随后放气，允许正常流过血管返回。
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28.发明授权公开(公告)号：US06979330B2
公开(公告)日：2005-12-27
申请号：US10387892
申请日：2003-03-13
CPC分类号： A61B18/1477 , A61B90/39 , A61B2018/143 , A61B2018/1432 , A61B2018/1495 , A61B2090/3987 , A61N1/06
摘要： Systems and methods are provided for ablating tissue by implanting a plurality of electrode devices within the tissue to be treated and exposing the implanted electrode devices with RF energy conveyed from a separate electrode device. In this manner, a greater region of tissue is ablated than what would normally be ablated with the separate electrode device. In addition, the implanted electrode devices can create a roadmap that allows the progress of the treatment to be managed during follow-ups. The implanted electrode devices can be variously delivered to the tissue, for example, by detaching the electrode devices from one or more delivery devices. For example, a core wire with an electrolytically detachable junction can be used to separate the electrode device from the core wire. Pusher rods with mechanically detachable junctions are also contemplated.
摘要翻译： 提供了系统和方法，用于通过将待治疗的组织内的多个电极装置植入而烧蚀组织，并且用从单独的电极装置输送的RF能量暴露所述植入的电极装置。 以这种方式，组织的较大区域比通常用单独的电极装置消融更多的区域被消融。 此外，植入的电极装置可以创建允许在随访期间对治疗进展进行管理的路线图。 植入的电极装置可以被不同地递送到组织，例如通过将电极装置从一个或多个递送装置分离。 例如，可以使用具有电解可分离结的芯线来将电极装置与芯线分离。 具有机械可拆卸接头的推杆也可以考虑。
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公开(公告)号：US06866660B2
公开(公告)日：2005-03-15
申请号：US10339055
申请日：2003-01-09
申请人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
发明人： Robert J. Garabedian , John Griego , Earl Bardsley , Dean A. Schaefer , Cang D. Dao , Steven M. Anderson
CPC分类号： A61M25/005 , A61M25/0053
摘要： An intravascular catheter that exhibits the combined features of superior flexibility, softness, radiopacity and oval/kink resistance. The catheter includes an elongate shaft having a proximal region, a distal region and a lumen extending therethrough. The proximal region of the shaft includes an inner lubricious polymer layer, a reinforcement layer and an outer layer. The reinforcement layer comprises a braid having one or more metallic members and a plurality of polymer members wherein each polymer member comprises a plurality of monofilaments, preferably formed of LCP. The polymer members of the braid provide improved flexibility and softness in addition to high burst pressure. The metallic member(s) of the braid provide improved radiopacity and oval/kink resistance. The catheter may also include a longitudinal member extending along the reinforcement layer.
摘要翻译： 一种血管内导管，其具有优异的柔韧性，柔软性，不透射线性和椭圆形/扭结阻力的组合特征。 导管包括细长轴，其具有近端区域，远侧区域和延伸穿过其中的内腔。 轴的近侧区域包括内部光滑聚合物层，加强层和外层。 加强层包括具有一个或多个金属构件和多个聚合物构件的编织物，其中每个聚合物构件包括多个单丝，优选由LCP形成。 除了高爆裂压力之外，编织物的聚合物构件提供了改善的柔韧性和柔软性。 编织物的金属构件提供了改善的射线不透性和椭圆形/扭结阻力。 导管还可以包括沿加强层延伸的纵向构件。
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公开(公告)号：US08617158B2
公开(公告)日：2013-12-31
申请号：US12849699
申请日：2010-08-03
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/14 , A61B90/04 , A61B2018/00005 , A61B2018/00017 , A61B2018/00023 , A61B2018/00029 , A61B2018/00577 , A61B2090/0445 , A61B2090/0481
摘要： A medical assembly and method are provided to effectively treat abnormal tissue, such as, a tumor. The target tissue is thermally ablated using a suitable source, such as RF or laser energy. A cooling shield is placed in contact with non-target tissue adjacent the target tissue, and actively cooled to conduct thermal energy away from the non-target tissue. In one method, the cooling shield can be placed between two organs, in which case, one of the two organs can comprise the target tissue, and the other of the two organs can comprise the non-target tissue. In this case, the cooling shield may comprise an actively cooled inflatable balloon, which can be disposed between the two organs when deflated, and then inflated. The inflatable balloon can be actively cooled by pumping a cooling medium through it. In another method, the cooling shield can be embedded within the non-target tissue. In this case, the cooling shield can comprise one or more needles. If a plurality of needles is used, they can be embedded into the non-target tissue in a series, e.g., a rectilinear or curvilinear arrangement. The needle(s) can be actively cooled by pumping a cooling medium through them.
摘要翻译： 提供医疗组件和方法来有效地治疗诸如肿瘤的异常组织。 使用适当的来源（例如RF或激光能量）将靶组织热消融。 将冷却屏蔽物放置成与目标组织相邻的非靶组织接触，并且主动冷却以将热能从非目标组织传导出去。 在一种方法中，冷却屏蔽可以放置在两个器官之间，在这种情况下，两个器官中的一个可以包括靶组织，并且两个器官中的另一个可以包括非靶组织。 在这种情况下，冷却屏蔽件可以包括主动冷却的可膨胀气囊，当气体放气时可以将气囊放置在两个器官之间，然后膨胀。 可以通过泵送冷却介质来主动冷却可充气球囊。 在另一种方法中，冷却屏蔽可以嵌入在非目标组织内。 在这种情况下，冷却罩可以包括一个或多个针。 如果使用多个针，则它们可以以一系列例如直线或曲线布置被嵌入到非目标组织中。 可以通过将冷却介质泵送通过它们来主动冷却针。
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