专利检索 ap:("Michal Ayalon-Soffer" OR "Sarah Pollock" OR "Ronen Shemesh" OR "Rotem Sorek" OR "Zurit Levine" OR "Zipi Shaqed" OR "Amir Toporik" OR "Gad S. Cojocaru" OR "Dvir Dahary" OR "Guy Kol" OR "Pinchas Akiva" OR "Amit Novik" OR "Sergey Nemzer" OR "Alexander Diber" OR "Maxim Shklar" OR "Osnat Sella-Tavor" OR "Lily Bazak" OR "Ariel Farkash" OR "Yossi Cohen") AND inv:"Amit Novik" 第 3 页

21.

发明申请
Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 有权
标题翻译：新型核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法

公开(公告)号：US20060172311A1

公开(公告)日：2006-08-03

申请号：US11043824

申请日：2005-01-27

申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh

发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh

IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28

CPC分类号： G01N33/6893 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/324 , G01N2800/325 , G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。

22.

发明申请
Methods and systems for annotating biomolecular sequences 审中-公开
标题翻译：注释生物分子序列的方法和系统

公开(公告)号：US20060068405A1

公开(公告)日：2006-03-30

申请号：US11043860

申请日：2005-01-27

申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein

发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein

IPC分类号： C12Q1/68 , G06F19/00

CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00

摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.

摘要翻译： 提供多肽序列和多核苷酸序列。还提供了关于这些序列的这些序列和用途的注释信息。

23.

发明申请
Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer 有权
标题翻译：新的核苷酸和氨基酸序列，以及其用于诊断乳腺癌的测定和方法

公开(公告)号：US20070259386A1

公开(公告)日：2007-11-08

申请号：US11711827

申请日：2007-02-28

申请人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tayor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar

发明人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tayor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar

IPC分类号： G01N33/53 , C07H21/04 , C07K14/00 , C07K16/18

CPC分类号： G01N33/57415 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158

摘要： Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.

摘要翻译： 乳腺癌的新型标记物既敏感又准确。这些标志物在乳腺癌中特异性地过表达，与正常的乳腺组织相反。这些标记物在患者样本中单独或组合的测量提供了诊断者可以与乳腺癌的可能诊断相关的信息。本发明的标记物单独或组合显示乳腺癌与非癌状态之间的高度差异检测。

24.

发明申请
Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 失效
标题翻译：新型核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法

公开(公告)号：US20080193941A1

公开(公告)日：2008-08-14

申请号：US11978203

申请日：2007-10-29

申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Avalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh

发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Avalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh

IPC分类号： C12Q1/68 , C07H21/04 , G01N33/53 , C07K16/00

CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327

摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.

摘要翻译： 心脏疾病的新型标志物既敏感又准确。与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。

25.

发明申请
Novel calcium channel variants and methods of use thereof 审中-公开
标题翻译：新型钙通道变体及其使用方法

公开(公告)号：US20060147946A1

公开(公告)日：2006-07-06

申请号：US11051725

申请日：2005-01-27

申请人： Pinchas Akiva , Alexander Dlber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekhari , Zipi Shaged , Moshe Olshansky , Arial Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanquing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein

发明人： Pinchas Akiva , Alexander Dlber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekhari , Zipi Shaged , Moshe Olshansky , Arial Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanquing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein

IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705

CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00

摘要： Novel alpha 1 subunit splice variants, including nucleic and amino acid sequences. Methods of use thereof are also described.

摘要翻译： 新的α1亚基剪接变体，包括核酸和氨基酸序列。还描述了其使用方法。

26.

发明授权
Brain natriuretic peptide spliced variant 有权
标题翻译：脑利钠肽拼接变体

公开(公告)号：US07332569B2

公开(公告)日：2008-02-19

申请号：US11043590

申请日：2005-01-27

申请人： Gad S. Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer

发明人： Gad S. Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer

IPC分类号： C07K14/435

CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325

摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.

摘要翻译： 新型BNP变体。根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。

27.

发明申请
Novel brain natriuretic peptide variants and methods of use thereof 审中-公开
标题翻译：新型脑利钠肽变体及其使用方法

公开(公告)号：US20080182299A1

公开(公告)日：2008-07-31

申请号：US11978204

申请日：2007-10-29

申请人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer

发明人： Gad S. Colocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer

IPC分类号： C12P19/34 , C07H21/00 , G01N33/50 , C07K14/00 , C07K16/18 , G01N33/68

CPC分类号： G01N33/74 , C07K14/58 , G01N2800/324 , G01N2800/325 , Y10T436/143333

摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.

摘要翻译： 新型BNP变体。根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。

28.

发明申请
Novel brain natriuretic peptide variants and methods of use thereof 有权
标题翻译：新型脑利钠肽变体及其使用方法

公开(公告)号：US20050277156A1

公开(公告)日：2005-12-15

申请号：US11043590

申请日：2005-01-27

申请人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer

发明人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer

IPC分类号： A61K38/17 , C07K14/705 , G01N33/53 , G01N33/74

CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325

摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.

摘要翻译： 新型BNP变体。根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。