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    Ultrasound contrast agents and process for the preparation thereof
    21.
    发明申请
    Ultrasound contrast agents and process for the preparation thereof 审中-公开
    超声造影剂及其制备方法

    公开(公告)号：US20060034770A1

    公开(公告)日：2006-02-16

    申请号：US11202008

    申请日：2005-08-11

    申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Christian Guillot

    发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Christian Guillot

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223

    摘要： Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbububbles with a diameter of 1.5 μm or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles.

    摘要翻译： 填充有生物相容性气体的微泡的可注射水性悬浮液及其制备方法。 包含在微泡中的气体的总体积的至少10％包含在直径为1.5μm或更小的微泡中。 微泡可以通过制备包含水性介质，磷脂和与水不混溶的有机溶剂的乳液来获得。 然后将乳液冷冻干燥，然后在气体填充的微泡的水性悬浮液中重构。

    Ultrasound contrast agents and methods of making and using them
    30.
    发明授权
    Ultrasound contrast agents and methods of making and using them 失效
    超声造影剂及其使用方法

    公开(公告)号：US06613306B1

    公开(公告)日：2003-09-02

    申请号：US09401838

    申请日：1999-09-22

    申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

    发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier ,  Jerome Puginier ,  Marie-Bernadette Barrau ,  Philippe Bussat ,  Eva Hybl ,  Daniel Bichon

    IPC分类号： A61B800

    CPC分类号： A61K49/223 ,  Y10S977/929

    摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

    摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有表面活性剂和任选的亲水稳定剂。 表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将表面活性剂暴露于空气或气体中来获得悬浮液。 通过使用作为填充气体的填充气体，其在水中的溶解度，以标准条件下以升水表示的水分数除以平方根，可以赋予在超声波回波造影中用作造影剂的这些充气微泡的压力下突出的抵抗压力崩溃的抵抗力 的分子量不超过0.003。 还公开了具有特定气体混合物的对比剂，其具有有利的性质。