公开(公告)号：US20190060438A1

公开(公告)日：2019-02-28

申请号：US15746286

申请日：2016-07-21

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu

IPC: A61K39/12

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20180344839A1

公开(公告)日：2018-12-06

申请号：US16009880

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61P31/12

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20180344838A1

公开(公告)日：2018-12-06

申请号：US16009848

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu

IPC: A61K39/12 ,  A61P31/14 ,  A61K9/51

CPC classification number: A61K39/12 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/51 ,  A61K9/5123 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/28 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/6056 ,  A61P31/14 ,  C07K14/005 ,  C07K16/1081 ,  C07K16/2851 ,  C07K2317/33 ,  C07K2317/76 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2770/36122 ,  C12N2770/36123 ,  C12N2770/36134 ,  Y02A50/383 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/392 ,  Y02A50/51

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20220370354A1

公开(公告)日：2022-11-24

申请号：US17608691

申请日：2020-05-08

Applicant: ModernaTX, Inc.

Inventor： Tal Zaks ,  Kelly Lindert ,  Lin Tung Guey

IPC: A61K9/127 ,  A61K31/7115 ,  A61K9/00 ,  A61K9/51 ,  A61P3/00

Abstract: This disclosure relates to mRNA therapy for the treatment of methylmalonic acidemia (MMA). mRNAs for use in the invention, when administered in vivo, encode methylmalonyl-CoA mutase (MUT). mRNA therapies of the disclosure increase and/or restore deficient levels of MUT expression and/or activity in subjects.

公开(公告)号：US20220347292A1

公开(公告)日：2022-11-03

申请号：US17641967

申请日：2020-09-11

Applicant: ModernaTX, Inc.

Inventor： Lori Panther ,  Shinu John ,  Tal Zaks

IPC: A61K39/245 ,  A61P31/22

Abstract: Aspects of the invention relate to methods for producing an antigen-specific immune response to human cytomegalovirus (hCMV) in a subject by administering mRNA vaccines comprising hCMV antigenic polypeptides gH, gL, UL128, UL130, UL131 A and gB formulated in lipid nanoparticles, wherein the antigen-specific immune response to hCMV results in neutralizing antibodies that have i) a geometric mean titer of at least 3-fold against epithelial cell infection or ii) a geometric mean ratio of 9-41 against epithelial cell infection or iii) a geometric mean ratio of 4-8-fold against fibroblast infection.

公开(公告)号：US11235052B2

公开(公告)日：2022-02-01

申请号：US16853973

申请日：2020-04-21

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20200368343A1

公开(公告)日：2020-11-26

申请号：US16897859

申请日：2020-06-10

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu

IPC: A61K39/12 ,  A61K9/00 ,  C07K16/28 ,  C07K14/005 ,  C07K16/10 ,  A61K9/14 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US10702597B2

公开(公告)日：2020-07-07

申请号：US16009880

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  C07K14/005 ,  A61K9/14 ,  A61K9/00 ,  C07K16/28 ,  C07K16/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51 ,  A61K39/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US10238731B2

公开(公告)日：2019-03-26

申请号：US15674591

申请日：2017-08-11

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K48/00 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20190008938A1

公开(公告)日：2019-01-10

申请号：US15748773

申请日：2016-07-29

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Nicholas Valiante ,  Tal Zaks

IPC: A61K39/00 ,  A61P35/00 ,  A61K47/68 ,  C12N15/62 ,  A61K9/127 ,  A61K47/54 ,  A61K47/26

Abstract: The invention relates to concatemeric peptide epitope RNAs, as well as methods and compositions thereof. mRNA vaccines are also provided according to the invention, including cancer vaccines.