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118 条记录 (耗时 0.069 秒)

    Detector module for an emission tomography scanner
    21.
    发明申请
    Detector module for an emission tomography scanner 有权
    用于发射断层扫描仪的检测器模块

    公开(公告)号：US20110074426A1

    公开(公告)日：2011-03-31

    申请号：US12585867

    申请日：2009-09-28

    申请人： Matthias J. Schmand ,  Markus Vester ,  Nan Zhang

    发明人： Matthias J. Schmand ,  Markus Vester ,  Nan Zhang

    IPC分类号： G01T1/164 ,  G01T1/20 ,  G01V3/00

    CPC分类号： A61B6/4411 ,  A61B5/0035 ,  A61B5/055 ,  A61B6/037 ,  A61B6/4417 ,  G01R33/481 ,  G01T1/1603 ,  G01T1/1644

    摘要： An emission tomography detector module and an emission tomography scanner are disclosed. In at least one embodiment, the emission tomography detector modules includes a scintillator to capture an photon, the scintillator emitting a scintillating light on capturing the photon; a first type of solid-state photodetector to detect the scintillating light; and a second type of solid-state photodetector to detect the scintillating light, wherein the first type of solid-state photodetector and the second type of solid-state photodetector are different with respect to a detecting property.

    摘要翻译： 公开了一种发射断层摄影检测器模块和发射断层扫描仪。 在至少一个实施例中，发射断层摄影检测器模块包括闪光体以捕获光子，闪烁体在捕获光子时发射闪烁光; 用于检测闪烁光的第一种类型的固态光电检测器; 以及用于检测闪烁光的第二类型的固态光电检测器，其中所述第一类型的固态光电检测器和所述第二类型的固态光电检测器相对于检测特性是不同的。

    BASELINE RESTORE BASED ON DIODE STAR CONFIGURATION AND TRANSFORMER COUPLING
    22.
    发明申请
    BASELINE RESTORE BASED ON DIODE STAR CONFIGURATION AND TRANSFORMER COUPLING 失效
    基于二极管配置和变压器耦合的基线恢复

    公开(公告)号：US20100066426A1

    公开(公告)日：2010-03-18

    申请号：US12558007

    申请日：2009-09-11

    申请人： Matthias J. Schmand ,  Nan Zhang

    发明人： Matthias J. Schmand ,  Nan Zhang

    IPC分类号： H03L5/00

    CPC分类号： G01T1/248

    摘要： A simple, low cost circuit with only passive components, and thus low power consumption, is provided for baseline restoration of an AC coupled signal. The circuit includes a passive network of diodes arranged in a star configuration and an RF-transformer. A differential signal strategy may be employed by including a differential amplifier at the input and output of the passive network.

    摘要翻译： 提供了一种简单的低成本电路，仅具有无源组件，因此具有低功耗，用于AC耦合信号的基线恢复。 该电路包括以星形结构布置的二极管的无源网络和RF变压器。 可以通过在无源网络的输入和输出处包括差分放大器来采用差分信号策略。

    Systems and methods for calibrating a silicon photomultiplier-based positron emission tomography system
    23.
    发明授权
    Systems and methods for calibrating a silicon photomultiplier-based positron emission tomography system 有权
    用于校准基于硅光电倍增管的正电子发射断层扫描系统的系统和方法

    公开(公告)号：US09588230B2

    公开(公告)日：2017-03-07

    申请号：US12560054

    申请日：2009-09-15

    申请人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

    发明人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

    IPC分类号： G01D18/00 ,  G12B13/00 ,  G01T1/164 ,  A61B6/03

    CPC分类号： G01T1/1644 ,  A61B6/037 ,  G01T1/1648

    摘要： A representative positron emission tomography (PET) system includes a positron emission tomography detector having one or more silicon photomultipliers that output silicon photomultipliers signals. The PET system further includes a calibration system that is electrically coupled to the silicon photomultipliers. The calibration system determines a single photoelectron response of the silicon photomultipliers signals and adjusts a gain of the silicon photomultipliers based on the single photoelectron response.

    摘要翻译： 代表性的正电子发射断层摄影（PET）系统包括正电子发射断层摄影检测器，其具有输出硅光电倍增管信号的一个或多个硅光电倍增管。 PET系统还包括电耦合到硅光电倍增管的校准系统。 校准系统确定硅光电倍增管信号的单个光电子响应，并且基于单个光电子响应调整硅光电倍增管的增益。

    Just-in-time analytics on large file systems
    24.
    发明授权
    Just-in-time analytics on large file systems 有权
    大型文件系统的即时分析

    公开(公告)号：US09244975B2

    公开(公告)日：2016-01-26

    申请号：US13328810

    申请日：2011-12-16

    申请人： Gautam Das ,  Hao H. Huang ,  Sandor Szalay ,  Nan Zhang

    发明人： Gautam Das ,  Hao H. Huang ,  Sandor Szalay ,  Nan Zhang

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30442

    摘要： As file systems reach the petabytes scale, users and administrators are increasingly interested in acquiring high-level analytical information for file management and analysis. Two particularly important tasks are the processing of aggregate and top-k queries which, unfortunately, cannot be quickly answered by hierarchical file systems such as ext3 and NTFS. Existing pre-processing based solutions, e.g., file system crawling and index building, consume a significant amount of time and space (for generating and maintaining the indexes) which in many cases cannot be justified by the infrequent usage of such solutions. User interests can often be sufficiently satisfied by approximate (i.e., statistically accurate) answers. A just-in-time sampling-based system can, after consuming a small number of disk accesses, produce extremely accurate answers for a broad class of aggregate and top-k queries over a file system without the requirement of any prior knowledge. The system is efficient, accurate and scalable.

    摘要翻译： 随着文件系统达到PB级，用户和管理员越来越有兴趣获取用于文件管理和分析的高级分析信息。 两个特别重要的任务是处理聚合和top-k查询，不幸的是不能通过分层文件系统（如ext3和NTFS）快速回答。 现有的基于预处理的解决方案，例如文件系统爬行和索引构建，消耗了大量的时间和空间（用于生成和维护索引），这在许多情况下不能被这种解决方案的频繁使用所证明。 用户兴趣通常可以通过近似（即统计准确的）答案来充分满足。 基于时间抽样的系统可以在消耗少量磁盘访问后，通过文件系统为广泛的聚合和顶级查询提供非常准确的答案，而无需任何先前的知识。 该系统是高效，准确和可扩展的。

    Energy correction for one-to-one coupled radiation detectors having non-linear sensors
    25.
    发明授权
    Energy correction for one-to-one coupled radiation detectors having non-linear sensors 有权
    具有非线性传感器的一对一耦合辐射探测器的能量校正

    公开(公告)号：US08884213B2

    公开(公告)日：2014-11-11

    申请号：US13539931

    申请日：2012-07-02

    申请人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

    发明人： Ronald Grazioso ,  Debora Henseler ,  Nan Zhang

    IPC分类号： G01T1/202 ,  G01T1/24

    CPC分类号： G01T1/248 ,  G01T1/202

    摘要： Systems and methods for correcting output signals from non-linear photosensors, specifically silicon photomultipliers (SiPMs). SiPMs are used in a PET detector to readout light emissions from LSO scintillator crystals. The non-linear output of the SiPM can distort and compress the energy spectrum which is crucial in PET imaging. The non-linearity effect for inter-crystal scattered events can place an energy event outside of the PET detector energy window, resulting in a rejected event. Systems and methods to correct the SiPM non-linearity for inter-crystal scattered events, so as to be able to obtain the proper energy event and produce an accurate medical image, are disclosed.

    摘要翻译： 用于校正非线性光电传感器，特别是硅光电倍增管（SiPM）的输出信号的系统和方法。 SiPM用于PET检测器以读出LSO闪烁体晶体的光发射。 SiPM的非线性输出可以扭曲和压缩在PET成像中至关重要的能谱。 晶体间散射事件的非线性效应可以将能量事件置于PET检测器能量窗口之外，导致被拒绝的事件。 公开了用于校正晶间散射事件的SiPM非线性的系统和方法，以便能够获得适当的能量事件并产生精确的医学图像。

    Compound for inhibiting type 5 phosphodiesterase and preparation method thereof
    26.
    发明授权
    Compound for inhibiting type 5 phosphodiesterase and preparation method thereof 有权
    抑制5型磷酸二酯酶的化合物及其制备方法

    公开(公告)号：US08859565B2

    公开(公告)日：2014-10-14

    申请号：US13512524

    申请日：2010-07-30

    申请人： Nan Zhang ,  Rong Zhong

    发明人： Nan Zhang ,  Rong Zhong

    IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  C07C59/265

    CPC分类号： C07D487/04 ,  A61K31/519 ,  C07C59/265

    摘要： The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.

    摘要翻译： 本发明公开了式（I）化合物及其柠檬酸盐作为5型磷酸二酯酶抑制剂及其制备方法，以及含有式（I）化合物及其柠檬酸盐的药物组合物。 本发明的实验结果证明，式（I）化合物及其柠檬酸盐可抑制5型磷酸二酯酶的活性，可用于治疗勃起功能障碍，抑制血小板聚集和治疗血栓形成，降低肺动脉高压和治疗心血管疾病 治疗哮喘和治疗糖尿病胃轻瘫。

    Analytical Cartridge with Fluid Flow Control
    27.
    发明申请
    Analytical Cartridge with Fluid Flow Control 有权
    具有流体流量控制的分析盒

    公开(公告)号：US20130004371A1

    公开(公告)日：2013-01-03

    申请号：US13608408

    申请日：2012-09-10

    申请人： Zhiliang Wan ,  Nan Zhang

    发明人： Zhiliang Wan ,  Nan Zhang

    IPC分类号： G01N21/75

    CPC分类号： G01N33/558 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/0631 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  Y10T137/0318

    摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.

    摘要翻译： 使用毛细管流分析样品的分析柱，系统和方法。 垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。 流量调节器可以包括没有侧壁的蛇形毛细管流动路径。 孵育的滤液可以在预定时间后从孵育室流出到检测通道。 检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。

    Analytical cartridge with fluid flow control
    29.
    发明申请
    Analytical cartridge with fluid flow control 有权
    具有流体流量控制的分析筒

    公开(公告)号：US20100009430A1

    公开(公告)日：2010-01-14

    申请号：US12456247

    申请日：2009-06-12

    申请人： Zhiliang Wan ,  Nan Zhang

    发明人： Zhiliang Wan ,  Nan Zhang

    IPC分类号： C12M1/00 ,  G01N33/53 ,  G01N21/01 ,  F17D1/00

    CPC分类号： G01N33/558 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/0631 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2400/0406 ,  Y10T137/0318

    摘要： Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.

    摘要翻译： 使用毛细管流分析样品的分析柱，系统和方法。 垂直梯度样品过滤将滤液提供到孵育室，由孵育室出口处的流动调节器控制一段时间。 流量调节器可以包括没有侧壁的蛇形毛细管流动路径。 孵育的滤液可以在预定时间后从孵育室流出到检测通道。 检测室可以在多孔基底中包括一个或多个分析区域，用于从相同的样品检测相同盒上的两种或更多种分析物。