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公开(公告)号：US07268160B2
公开(公告)日：2007-09-11
申请号：US10182193
申请日：2001-01-26
申请人： Hiromu Ohnogi , Masahiro Shiraga , Eiji Kobayashi , Tuo-Ping Li , Suzu Deguchi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Masahiro Shiraga , Eiji Kobayashi , Tuo-Ping Li , Suzu Deguchi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/35 , A61K31/22 , C07D307/02 , C07C67/02
CPC分类号： A61K31/7004 , A23L33/10 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352
摘要： The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.
摘要翻译： 本发明提供了需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或用于增强神经生长因子产生的食品，饮料或饲料，其各自包含作为有效成分 具有增强神经生长因子生成活性的特定化合物或其盐; 一种用于增强神经生长因子产生的方法，包括向哺乳动物施用上述化合物或其盐; 以及上述化合物或其盐在制备需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或食品，饮料或饲料中的用途 增强神经生长因子的产生。 此外，本发明提供了具有增强神经生长因子产生活性的新型化合物。
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公开(公告)号：US20100317613A1
公开(公告)日：2010-12-16
申请号：US12445784
申请日：2007-10-11
申请人： Hiromu Ohnogi , Yoko Kudo , Hiroko Nakahara , Tatsuji Enoki , Ikunoshin Kato
发明人： Hiromu Ohnogi , Yoko Kudo , Hiroko Nakahara , Tatsuji Enoki , Ikunoshin Kato
IPC分类号： A61K31/715 , A61P25/00
CPC分类号： A61K31/729 , A23K20/121 , A23L33/105 , A61K31/351 , A61K31/7016 , A61K31/702
摘要： It is intended to provide a drug, a food or a feed which has an effect of enhancing the activity of a second-phase detoxifying enzyme and an effect of increasing intracellular glutathione content.
摘要翻译： 旨在提供具有增强第二阶段解毒酶的活性和增加细胞内谷胱甘肽含量的作用的药物，食物或饲料。
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公开(公告)号：US20060199774A1
公开(公告)日：2006-09-07
申请号：US11408946
申请日：2006-04-24
IPC分类号： A61K31/366 , A61K31/7048
CPC分类号： A61K31/7048 , A23K20/116 , A23K20/163 , A23L33/105 , A61K31/366 , A61K31/37 , C07H17/04 , C07H17/075
摘要： The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.
摘要翻译： 本发明涉及一种药物，食品，饮料或饲料，其各自包含作为有效成分的具有NGF生产增强作用的化合物，其有效治疗，改善症状，预防等 需要增强NGF生产的疾病，其中所述化合物具有香豆素和/或色胺骨架。 由于在本发明的有效成分中没有特别的毒性，并且不存在不良反应的发生风险，所以可以安全，适当地进行上述疾病的治疗等。
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公开(公告)号：US20060147558A1
公开(公告)日：2006-07-06
申请号：US11258163
申请日：2005-10-26
申请人： Hiromu Ohnogi , Masahiro Shiraga , Tuo-Ping Li , Eiji Kobayashi , Kaori Nishimura , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Masahiro Shiraga , Tuo-Ping Li , Eiji Kobayashi , Kaori Nishimura , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K36/899 , A61K36/16 , A61K36/8962 , A61K36/31 , A61K36/906 , A61K36/28 , A61K36/23
CPC分类号： C12G3/06 , A23F3/163 , A23K20/00 , A23K20/10 , A23L2/02 , A23L2/52 , A23L33/105 , A61K31/12 , A61K31/192 , A61K31/216 , A61K31/7048 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/31 , A61K36/48 , A61K36/60 , A61K36/73 , A61K36/896 , A61K36/899 , A61K36/906 , A61K2300/00
摘要： The present invention provides a composition for enhancing growth factor production, comprising a plant-derived enhancer for growth factor production; a therapeutic agent or prophylactic agent for a disease requiring enhancement of growth factor production and a food, beverage or feed for enhancing growth factor production, each comprising the above composition. In addition, the present invention relates to a functional food, beverage or feed excellent in health enhancement.
摘要翻译： 本发明提供一种用于增强生长因子生产的组合物，其包含用于生长因子生产的植物来源的增强剂; 用于需要增强生长因子产生的疾病的治疗剂或预防剂和用于增强生长因子产生的食品，饮料或饲料，每种包含上述组合物。 此外，本发明涉及健康增强优异的功能性食品，饮料或饲料。
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公开(公告)号：US20060051316A1
公开(公告)日：2006-03-09
申请号：US10537333
申请日：2003-12-05
IPC分类号： A61K31/74 , A61K31/737 , A61K31/727 , A61K31/715
CPC分类号： A61K36/02 , A23L33/10 , A61K31/216 , A61K31/737 , A61K31/78
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of bone morphogenetic protein production or promotion of osteogenesis; an agent for enhancement of bone morphogenetic protein production or an agent for promotion of osteogenesis, a food, beverage or feed for enhancement of bone mornhogenetic protein production or promotion of osteogenesis, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of (a) an acidic saccharide, (b) a polyacrylic acid, (c) chlorogenic acid and (d) an oxidation processed product of chlorogenic acid, or an extract derived from algae.
摘要翻译： 本发明涉及需要增强骨形态发生蛋白产生或促进成骨的疾病的治疗剂或预防剂; 用于增强骨形态发生蛋白质产生的药物或用于促进成骨的药剂，用于增强骨发生蛋白质产生或促进成骨的食品，饮料或饲料，其特征在于，每种药物包含作为有效成分的至少一种选自 由（a）酸性糖，（b）聚丙烯酸，（c）绿原酸和（d）绿原酸的氧化加工产物或源自藻类的提取物组成的组。
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26.发明申请Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species 审中-公开用于促进成骨的食物饮料或饲料，包括伞形花序，百合科或合成植物物种公开(公告)号：US20080008773A1
公开(公告)日：2008-01-10
申请号：US11819441
申请日：2007-06-27
IPC分类号： A61K36/886 , A61K36/00 , A61P19/00 , A61K36/28
CPC分类号： C07D311/80 , A23K20/121 , A23L33/105 , A23V2002/00 , A61K31/353 , A61K36/23 , A61K36/232 , A61K36/282 , A61K36/8967 , A23V2200/306 , A23V2250/21
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.
摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。
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27.发明授权Enhancing agent for nerve growth factor production comprising a compound having a coumarin backbone or a compound having a 2-dimethyl chroman backbone 失效包含具有香豆素骨架的化合物或具有2-二甲基苯并二氢吡喃骨架的化合物的神经生长因子生产增强剂公开(公告)号：US07078386B2
公开(公告)日：2006-07-18
申请号：US10474708
申请日：2002-03-28
IPC分类号： A61K31/70 , A23L2/00 , C07H15/24 , C07D311/00
CPC分类号： A61K31/7048 , A23K20/116 , A23K20/163 , A23L33/105 , A61K31/366 , A61K31/37 , C07H17/04 , C07H17/075
摘要： The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.
摘要翻译： 本发明涉及一种药物，食品，饮料或饲料，其各自包含作为有效成分的具有NGF生产增强作用的化合物，其有效治疗，改善症状，预防等 需要增强NGF生产的疾病，其中所述化合物具有香豆素和/或色胺骨架。 由于在本发明的有效成分中没有特别的毒性，并且不存在不良反应的发生风险，所以可以安全，适当地进行上述疾病的治疗等。
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公开(公告)号：US20060039998A1
公开(公告)日：2006-02-23
申请号：US10529860
申请日：2003-09-29
IPC分类号： A61K36/282 , A61K36/232 , A61K36/896 , A61K36/886
CPC分类号： C07D311/80 , A23K20/121 , A23L33/105 , A23V2002/00 , A61K31/353 , A61K36/23 , A61K36/232 , A61K36/282 , A61K36/8967 , A23V2200/306 , A23V2250/21
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.
摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。
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公开(公告)号：US20050250715A1
公开(公告)日：2005-11-10
申请号：US10521447
申请日：2003-07-17
IPC分类号： A23L1/30 , A61K31/56 , A61K31/704 , A61P9/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P43/00 , C07H15/256 , C07J63/00
CPC分类号： C07J63/00 , A23L33/10 , A61K31/56 , A61K31/704 , C07H15/256 , A61K2300/00
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor (NGF) production upon treatment or prevention, an enhancing agent for nerve growth factor production, and a food, beverage or feed for enhancing nerve growth factor production, characterized in that each comprises as an effective ingredient a compound selected from the group consisting of soyasaponin compounds, soyasapogenin compounds, glycyrrhizin and salts thereof. In addition, the present invention relates to a novel soyasaponin compound and a novel soyasapogenin compound, having an action for enhancement of NGF production.
摘要翻译： 本发明涉及治疗或预防需要增强神经生长因子（NGF）产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂，以及用于增强神经生长因子的食品，饮料或饲料 其特征在于，各自包含选自由大豆皂角苷化合物，大豆皂草苷化合物，甘草甜素及其盐组成的组的有效成分。 此外，本发明涉及一种新的大豆皂草素化合物和具有增强NGF产生作用的新型大豆皂草配基化合物。
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公开(公告)号：US20100105867A1
公开(公告)日：2010-04-29
申请号：US12530270
申请日：2008-03-05
摘要： A process for producing an extract containing activated osteocalcin; an extract which can be obtained by this production process; a food, a drink, a drug, an oral cavity-care composition and a feed containing this extract; and a growth enhancer containing osteocalcin originating in a bone.
摘要翻译： 一种生产含有活化骨钙素的提取物的方法; 可以通过该生产过程获得的提取物; 食物，饮料，药物，口腔护理组合物和含有该提取物的饲料; 以及含有源于骨的骨钙素的生长增强剂。
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