公开(公告)号：US20100105867A1

公开(公告)日：2010-04-29

申请号：US12530270

申请日：2008-03-05

申请人： Hiromu Ohnogi ,  Shinichi Adachi ,  Kazuo Nakagawa ,  Hiroki Iwamoto ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Shinichi Adachi ,  Kazuo Nakagawa ,  Hiroki Iwamoto ,  Ikunoshin Kato

IPC分类号： A61K38/16 ,  A61P1/02 ,  C07K14/00

CPC分类号： A61K38/39 ,  A61K35/32

摘要： A process for producing an extract containing activated osteocalcin; an extract which can be obtained by this production process; a food, a drink, a drug, an oral cavity-care composition and a feed containing this extract; and a growth enhancer containing osteocalcin originating in a bone.

摘要翻译： 一种生产含有活化骨钙素的提取物的方法; 可以通过该生产过程获得的提取物; 食物，饮料，药物，口腔护理组合物和含有该提取物的饲料; 以及含有源于骨的骨钙素的生长增强剂。

公开(公告)号：US20100317613A1

公开(公告)日：2010-12-16

申请号：US12445784

申请日：2007-10-11

申请人： Hiromu Ohnogi ,  Yoko Kudo ,  Hiroko Nakahara ,  Tatsuji Enoki ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Yoko Kudo ,  Hiroko Nakahara ,  Tatsuji Enoki ,  Ikunoshin Kato

IPC分类号： A61K31/715 ,  A61P25/00

CPC分类号： A61K31/729 ,  A23K20/121 ,  A23L33/105 ,  A61K31/351 ,  A61K31/7016 ,  A61K31/702

摘要： It is intended to provide a drug, a food or a feed which has an effect of enhancing the activity of a second-phase detoxifying enzyme and an effect of increasing intracellular glutathione content.

摘要翻译： 旨在提供具有增强第二阶段解毒酶的活性和增加细胞内谷胱甘肽含量的作用的药物，食物或饲料。

公开(公告)号：US20060199774A1

公开(公告)日：2006-09-07

申请号：US11408946

申请日：2006-04-24

申请人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/366 ,  A61K31/7048

CPC分类号： A61K31/7048 ,  A23K20/116 ,  A23K20/163 ,  A23L33/105 ,  A61K31/366 ,  A61K31/37 ,  C07H17/04 ,  C07H17/075

摘要： The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.

摘要翻译： 本发明涉及一种药物，食品，饮料或饲料，其各自包含作为有效成分的具有NGF生产增强作用的化合物，其有效治疗，改善症状，预防等 需要增强NGF生产的疾病，其中所述化合物具有香豆素和/或色胺骨架。 由于在本发明的有效成分中没有特别的毒性，并且不存在不良反应的发生风险，所以可以安全，适当地进行上述疾病的治疗等。

公开(公告)号：US20060147558A1

公开(公告)日：2006-07-06

申请号：US11258163

申请日：2005-10-26

申请人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Tuo-Ping Li ,  Eiji Kobayashi ,  Kaori Nishimura ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Masahiro Shiraga ,  Tuo-Ping Li ,  Eiji Kobayashi ,  Kaori Nishimura ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/899 ,  A61K36/16 ,  A61K36/8962 ,  A61K36/31 ,  A61K36/906 ,  A61K36/28 ,  A61K36/23

CPC分类号： C12G3/06 ,  A23F3/163 ,  A23K20/00 ,  A23K20/10 ,  A23L2/02 ,  A23L2/52 ,  A23L33/105 ,  A61K31/12 ,  A61K31/192 ,  A61K31/216 ,  A61K31/7048 ,  A61K36/16 ,  A61K36/185 ,  A61K36/23 ,  A61K36/28 ,  A61K36/31 ,  A61K36/48 ,  A61K36/60 ,  A61K36/73 ,  A61K36/896 ,  A61K36/899 ,  A61K36/906 ,  A61K2300/00

摘要： The present invention provides a composition for enhancing growth factor production, comprising a plant-derived enhancer for growth factor production; a therapeutic agent or prophylactic agent for a disease requiring enhancement of growth factor production and a food, beverage or feed for enhancing growth factor production, each comprising the above composition. In addition, the present invention relates to a functional food, beverage or feed excellent in health enhancement.

摘要翻译： 本发明提供一种用于增强生长因子生产的组合物，其包含用于生长因子生产的植物来源的增强剂; 用于需要增强生长因子产生的疾病的治疗剂或预防剂和用于增强生长因子产生的食品，饮料或饲料，每种包含上述组合物。 此外，本发明涉及健康增强优异的功能性食品，饮料或饲料。

公开(公告)号：US06548543B1

公开(公告)日：2003-04-15

申请号：US09763244

申请日：2001-02-20

申请人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Eiji Kobayashi ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31215

CPC分类号： A61K31/215 ,  A61K31/22 ,  C07C69/013 ,  C07C2601/10 ,  Y02A50/411

摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

摘要翻译： 需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病 含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为 相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

公开(公告)号：US20070060641A1

公开(公告)日：2007-03-15

申请号：US10557268

申请日：2004-05-18

申请人： Tatsuji Enoki ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/343 ,  A61K31/225 ,  A61K31/19 ,  A61K31/192 ,  A61K31/11

CPC分类号： A61K31/11 ,  A23K20/00 ,  A23L33/10

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入 细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。

公开(公告)号：US06284801B1

公开(公告)日：2001-09-04

申请号：US09380239

申请日：1999-08-27

申请人： Nobuto Koyama ,  Hua-Kang Wu ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Tatsuji Enoki ,  Hiromu Ohnogi ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Hua-Kang Wu ,  Takanari Tominaga ,  Eiji Nishiyama ,  Michio Hagiya ,  Tatsuji Enoki ,  Hiromu Ohnogi ,  Ikunoshin Kato

IPC分类号： A61K3112

CPC分类号： C07C323/59 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/21 ,  A23V2250/70 ,  A23V2250/06 ,  A23V2250/204

摘要： An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula [I] and an optically active substance and a salt thereof as an effective component.

摘要翻译： 一种抗风湿剂，其特征在于含有至少一种选自由下式[I]表示的4,5-二羟基-2-环戊烯-1-酮的化合物和光学活性物质及其盐作为 有效成分。

公开(公告)号：US20090076136A1

公开(公告)日：2009-03-19

申请号：US12263809

申请日：2008-11-03

申请人： Tatsuji ENOKI ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji ENOKI ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/343 ,  A61K31/225 ,  A61K31/19 ,  A61K31/192 ,  A61K31/11 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/11 ,  A23K20/00 ,  A23L33/10

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入 细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。

公开(公告)号：US07498357B2

公开(公告)日：2009-03-03

申请号：US10581034

申请日：2004-12-01

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Tatsuji Enoki ,  Eiji Kobayashi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Tatsuji Enoki ,  Eiji Kobayashi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/343 ,  C07D307/80

CPC分类号： C07D493/08 ,  A23K20/121 ,  A23L33/10 ,  C07C49/835 ,  C07C49/84 ,  C07C409/08 ,  C07D307/80

摘要： The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In addition, the present invention provides a medicament, a food, a beverage or a feed having a therapeutic or prophylactic effect for a disease showing sensitivity to the compound, by utilizing the physiological actions of the compound.

摘要翻译： 本发明提供了具有NO产生抑制作用或醛糖还原酶抑制作用的新型查耳酮化合物及其衍生物或其盐。 此外，本发明通过利用化合物的生理作用，提供对化合物显示敏感性的疾病具有治疗或预防作用的药物，食品，饮料或饲料。

公开(公告)号：US20070092587A1

公开(公告)日：2007-04-26

申请号：US10561431

申请日：2004-06-18

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/232

CPC分类号： A61K36/232 ,  A23L2/02 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/328

摘要： The present invention provides an extract obtainable by extracting a plant belonging to Umbelliferae, or a processed product thereof, with a water-containing alcohol; a process for preparing the extract; a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response and/or diabetic complications, characterized in that the therapeutic agent or prophylactic agent comprises as an effective ingredient the extract as defined above; an agent for an insulin-mimetic action, characterized in that the agent comprises as an effective ingredient the extract as defined above; a food, beverage or feed, comprising the extract as defined above; an agent for enhancing glucose uptake into a cell, characterized in that the agent comprises as an effective ingredient the extract as defined above; to an agent for inducing differentiation into an adipocyte, characterized in that the agent comprises as an effective ingredient the extract as defined above; and an inhibitory agent for aldose reductase, characterized in that the agent comprises as an effective ingredient the extract as define above.

摘要翻译： 本发明提供通过用含水醇提取属于伞形赤霉属的植物或其加工产物而获得的提取物; 一种制备提取物的方法; 用于伴随胰岛素或胰岛素反应量和/或糖尿病并发症的异常的疾病的治疗剂或预防剂，其特征在于所述治疗剂或预防剂包含作为有效成分的上述提取物; 用于胰岛素模拟作用的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 包含上述提取物的食品，饮料或饲料; 用于增强葡萄糖摄入细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 涉及诱导分化为脂肪细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 以及醛糖还原酶抑制剂，其特征在于，所述药剂含有作为有效成分的上述定义的提取物。