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    PREPARATION OF BETA-AMINO ACIDS
    22.
    发明申请
    PREPARATION OF BETA-AMINO ACIDS 有权
    β-氨基酸的制备

    公开(公告)号：US20120270280A1

    公开(公告)日：2012-10-25

    申请号：US13496086

    申请日：2010-09-15

    申请人： Nina Schneider ,  Bernhard Hauer ,  Klaus Ditrich ,  Maeve O'Neil ,  Nick Turner

    发明人： Nina Schneider ,  Bernhard Hauer ,  Klaus Ditrich ,  Maeve O'Neil ,  Nick Turner

    IPC分类号： C12P13/04 ,  C12N9/86

    CPC分类号： C12N9/86 ,  C12P13/04

    摘要： The present invention relates to a process for the biocatalytic, enantioselective production of a β-amino acid pre-cursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a β-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production of a β-amino acid pre-cursor or a β-amino acid, and a method for obtaining said hydantoinase.

    摘要翻译： 本发明涉及使用乙内酰脲酶和/或二氢嘧啶苷从任选取代的二氢尿嘧啶生物催化，对映选择性生产“氨基酸”前体的方法，一种从所述前体制备“氨基酸”的方法 ，乙内酰脲及其用于生物催化生产氨基酸前体或氨基酸的所述方法中的用途以及获得所述乙内酰脲酶的方法。

    Process for hydrolyzing optically active amides
    27.
    发明授权
    Process for hydrolyzing optically active amides 有权
    水解光学活性酰胺的方法

    公开(公告)号：US06713652B1

    公开(公告)日：2004-03-30

    申请号：US09936348

    申请日：2001-09-11

    申请人： Klaus Ditrich ,  Wolfgang Ladner ,  Johann-Peter Melder

    发明人： Klaus Ditrich ,  Wolfgang Ladner ,  Johann-Peter Melder

    IPC分类号： C07C20900

    CPC分类号： C07C209/62 ,  C07B2200/07 ,  C07C211/27

    摘要： The present invention relates to a process for hydrolyzing optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, where the hydrolysis of the amides is carried out with an alkali metal or alkaline earth metal hydroxide in the presence of 5-30% by weight, based on the amide employed, of a polyol or an amino alcohol.

    摘要翻译： 本发明涉及一种将光学活性酰胺水解成羧酸和光学活性胺的方法，其中保留了手性中心，其中酰胺的水解在碱土金属或碱土金属氢氧化物存在下进行5 -30重量％，基于所使用的酰胺，多元醇或氨基醇。

    Oxazole- and thiazolecarboxamides
    28.
    发明授权
    Oxazole- and thiazolecarboxamides 失效
    恶唑和噻唑甲酰胺

    公开(公告)号：US5284821A

    公开(公告)日：1994-02-08

    申请号：US919457

    申请日：1992-07-27

    申请人： Klaus Ditrich ,  Volker Maywald ,  Gerhard Hamprecht ,  Albrecht Harreus ,  Bruno Wuerzer ,  Karl-Otto Westphalen

    发明人： Klaus Ditrich ,  Volker Maywald ,  Gerhard Hamprecht ,  Albrecht Harreus ,  Bruno Wuerzer ,  Karl-Otto Westphalen

    IPC分类号： A01N43/74 ,  C07D263/34 ,  C07D277/56 ,  C07D417/04 ,  A01N43/76

    CPC分类号： C07D263/34 ,  A01N43/74 ,  C07D277/56 ,  C07D417/04

    摘要： Oxazole- and thiazolecarboxamides of the formulae Ia and Ib ##STR1## where the substituents have the following meanings: X oxygen or sulfur;R.sup.1 hydrogen; halogen; substituted or unsubstituted C.sub.1 -C.sub.6 -alkyl, benzyl, cycloalkyl, alkenyl, alkynyl, phenyl, phenoxy or phenylthio; alkoxy; alkylthio; haloalkoxy; haloalkylthio; or a substituted or unsubstituted 5- or 6-membered heterocyclic radical;R.sup.2 formyl, 4,5-dihydrooxazol-2-yl or --COYR.sup.5 ;Y oxygen or sulfur;R.sup.5 hydrogen; cycloalkyl; substituted or unsubstituted alkyl, phenyl, benzyl, alkenyl, cycloalkenyl or alkynyl; a substituted or unsubstituted 5- or 6-membered heterocyclic radical; phthalimido; tetrahydrophthalimido; succinimido; maleiimido; one equivalent of a cation; or--N.dbd.CR.sup.6 R.sup.7 ; R.sup.6, R.sup.7 hydrogen; alkyl; cycloalkyl; phenyl; furyl or together a methylene chain of 4 to 7 members;R.sup.3 hydrogen or substituted or unsubstituted alkyl or cycloalkyl;R.sup.4 hydroxy; alkoxy; substituted or unsubstituted alkyl, cycloalkyl, alkenyl, alkynyl, phenyl or naphthyl; a substituted or unsubstituted 5- or 6-membered heterocyclic radical; or R.sup.3 and R.sup.4 together are --(CH.sub.2).sub.n --Y.sub.p --(CH.sub.2).sub.q --, where n and q are 1, 2 or 3, p is 0 or 1 and Y is oxygen, sulfur or N-methyl, or form a radical of the formula --(CH.sub.2).sub.3 --CO--, and their environmentally tolerated salts,X in formula Ib not being sulfur when R.sup.1 is 3-pyridyl, R.sup.2 is CO.sub.2 CH.sub.2 CH.sub.3 or R.sup.3 is hydrogen, and X in formula Ia X not being sulfur and R.sup.1 not being thien-2-yl when YR.sup.5 is OH, R.sup.3 is hydrogen and R.sup.4 is methyl, processes for manufacturing such compounds and herbicidal agents containing compounds of the formulae Ia or Ib as active ingredients.

    摘要翻译： 式Ia和Ib的恶唑和噻唑甲酰胺其中取代基具有以下含义：X氧或硫; R1氢; 卤素; 取代或未取代的C 1 -C 6烷基，苄基，环烷基，烯基，炔基，苯基，苯氧基或苯硫基; 烷氧基 烷硫基 卤代烷氧基 卤代烷硫基; 或取代或未取代的五元或六元杂环基; R2甲酰基，4,5-二氢恶唑-2-基或-COYR 5; Y氧或硫; R5氢; 环烷基 取代或未取代的烷基，苯基，苄基，烯基，环烯基或炔基; 取代或未取代的5或6元杂环基; 邻苯二甲酰亚氨基 四氢邻苯二甲酰亚胺 琥珀酰亚胺 马来西亚 一个阳离子; 或-N = CR 6 R 7; R6，R7氢; 烷基; 环烷基 苯基; 呋喃基或一起形成4至7个成员的亚甲基链; R3氢或取代或未取代的烷基或环烷基; R4羟基 烷氧基 取代或未取代的烷基，环烷基，烯基，炔基，苯基或萘基; 取代或未取代的5或6元杂环基; 或者R 3和R 4一起是 - （CH 2）n -Yp-（CH 2）q - ，其中n和q是1,2或3，p是0或1，Y是氧，硫或N-甲基，或形成 式（（CH2）3-CO-）及其环境耐受盐的基团，当R1为3-吡啶基时，式Ib中的X不为硫，R2为CO2CH2CH3或R3为氢，式Ia中的X为硫， 并且当YR 5是OH时，R 1不是噻吩-2-基，R 3是氢，R 4是甲基，制备这种化合物的方法和含有式Ia或Ib化合物的除草剂作为活性成分。

    Sulfonamides
    29.
    发明授权
    Sulfonamides 失效
    磺胺

    公开(公告)号：US5171353A

    公开(公告)日：1992-12-15

    申请号：US521032

    申请日：1990-05-09

    申请人： Klaus Fischer ,  Horst Mayer ,  Klaus Ditrich ,  Gerhard Hamprecht ,  Bruno Wuerzer ,  Karl-Otto Westphalen

    发明人： Klaus Fischer ,  Horst Mayer ,  Klaus Ditrich ,  Gerhard Hamprecht ,  Bruno Wuerzer ,  Karl-Otto Westphalen

    IPC分类号： A01N43/90 ,  C07D471/04 ,  C07D473/06 ,  C07D473/40

    CPC分类号： C07D471/04 ,  A01N43/90 ,  C07D473/06 ,  C07D473/40

    摘要： Sulfonamides of the general formula I ##STR1## where R.sup.1 is hydrogen of C.sub.1 -C.sub.4 -alkyl,R.sup.2 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.6 -alkyl; C.sub.3 -C.sub.4 -alkenyl; C.sub.3 -C.sub.4 -alkynyl or substituted or unsubstituted saturated or singly unsaturated 5- to 7- membered heteroaryl;R.sup.3 and R.sup.4 are halogen; substituted or unsubstituted C.sub.1 -C.sub.4 -alkoxy C.sub.1 -C.sub.4 -alkylthio, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.2 -C.sub.6 -alkenylthio, C.sub.2 -C.sub.6 -alkynyl, C.sub.2 -C.sub.6 -alkynyloxy, C.sub.2 -C.sub.6 -alkynylthio, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkylthio, C.sub.5 -C.sub.6 -cycloalkenyl, C.sub.3 -C.sub.6 -cycloalkoxy, C.sub.5 -C.sub.6 -cycloalkenyloxy, C.sub.5 -C.sub.6 -cycloalkenylthio, phenyl, phenoxy, phenylthio, benzyl, benzyloxy or benzylthio;the group given for R.sup.2, or NR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.5 -C.sub.6 -cycloalkenyl, substituted or unsubstituted phenyl and/or benzyl bedeuten, or issubstituted or unsubstituted C.sub.4 -C.sub.6 -alkylene which may be interrupted or oxygen, sulfur or nitrogen;X is nitrogen or .dbd.CR.sup.5 14 ,where R.sup.5 is one of the radicals R.sup.3,n is 0 or 1 andA is substituted or unsubstituted mono- or dinuclear aryl containing one or two nitrogen, oxygen and/or sulfur atoms,and their agriculturally useful salts, and herbicidal and growth-regulating agents containing them.

    摘要翻译： 其中R 1是C 1 -C 4 - 烷基的氢，R 2是氢或被取代或未被取代的C 1 -C 6 - 烷基的磺酰胺， C3-C4-烯基; C3-C4-炔基或取代或未取代的饱和或单不饱和5-至7-元杂芳基; R3和R4是卤素; 取代或未取代的C 1 -C 4 - 烷氧基C 1 -C 4 - 烷硫基，C 2 -C 6 - 链烯基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 烯硫基，C 2 -C 6炔基，C 2 -C 6 - 炔氧基，C 2 -C 6 - 炔硫基， C 3 -C 6环烷基，C 3 -C 6环烷硫基，C 5 -C 6环环烯基，C 3 -C 6环烷氧基，C 5 -C 6环环烯氧基，C 5 -C 6环环硫基，苯基，苯氧基，苯硫基，苄基，苄氧基或苄硫基; R2或NR7R8的基团，其中R7和R8是氢，C1-C6-烷基，C3-C6-烯基，C3-C6-炔基，C3-C6-环烷基，C5-C6-环烯基，取代或未取代的苯基 或/或苄基叔丁基醚，或者是可被中断的取代或未取代的C 4 -C 6亚烷基或氧，硫或氮; X是氮或= CR514，其中R5是基团R3之一，n是0或1，A是含有一个或两个氮，氧和/或硫原子的取代或未取代的单核或二核芳基及其农业上有用的盐 ，和含有它们的除草和生长调节剂。