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28 条记录 (耗时 0.018 秒)

    Process for preparation of erythromycin compounds
    21.
    发明授权
    Process for preparation of erythromycin compounds 失效
    红霉素化合物的制备方法

    公开(公告)号：US06906039B2

    公开(公告)日：2005-06-14

    申请号：US10480275

    申请日：2002-06-12

    申请人： Hiroyuki Miyata ,  Akira Takama ,  Yasuhito Yamamoto ,  Kikuo Ataka

    发明人： Hiroyuki Miyata ,  Akira Takama ,  Yasuhito Yamamoto ,  Kikuo Ataka

    IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61K31/70

    CPC分类号： C07H17/08

    摘要： The present invention is to provide a process for producing a 2′-O-acetyl-4″-O-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2′-O-acetylerythromycin A compound 2 to obtain 2′-O-acetyl-4″-O-formylerythromycin A compound 3, then, acting an acid on Compound 3 to subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compound 4 as free crystals.

    摘要翻译： 本发明提供一种制备2'-O-乙酰基-4'-O-甲酰基-8,9-脱水红霉素A 6,9-半缩酮化合物 4的方法， 提供一种生产红霉素化合物的方法，其包括使甲酰化试剂与2'-O-乙酰红霉素A化合物 2反应，得到2'-O-乙酰基-4'-O-甲酰基红霉素A 化合物 3，然后在化合物 3上加入酸，进行半辛化，然后在水溶液中加入碱性水溶液沉淀化合物 4作为自由晶体。

    7a-alkoxy-4H-pyrano[3,2-d]-oxazol-2(3H)-one and process for producing the same
    22.
    发明授权
    7a-alkoxy-4H-pyrano[3,2-d]-oxazol-2(3H)-one and process for producing the same 失效
    7a-烷氧基-4H-吡喃并[3,2-d] - 恶唑-2（3H） - 酮及其制备方法

    公开(公告)号：US06723860B2

    公开(公告)日：2004-04-20

    申请号：US09988042

    申请日：2001-11-16

    申请人： Hiroyuki Miyata ,  Takashi Honma ,  Yasuhito Yamamoto ,  Kikuo Ataka

    发明人： Hiroyuki Miyata ,  Takashi Honma ,  Yasuhito Yamamoto ,  Kikuo Ataka

    IPC分类号： C07D49504

    CPC分类号： C07D498/04

    摘要： The present invention provides a novel 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one represented by the formula (I): wherein R1 and R2 each represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group; R3 represents an alkyl group, a cyclo-alkyl group, an alkenyl group, an aryl group or an aralkyl group, provided that a 2-alkenyl group is excluded from the alkenyl group of R3; and R4 represents an alkyl group, an aryl group, an alkoxycarbonyl group or a cyano group, and a process for producing the same which comprises reacting 5-alkoxy-2(3H)-oxazolone with an &agr;,&bgr;-unsaturated ketone in the presence of a Lewis acid in a solvent.

    摘要翻译： 本发明提供由式（I）表示的新的7a-烷氧基-4H-吡喃并[3,2-d]恶唑-2（3H） - 酮：其中R 1和R 2各自代表 氢原子，烷基，烯基，芳基或芳烷基; R 3表示烷基，环烷基，烯基，芳基或芳烷基，条件是从R 3的烯基中排除2-烯基; 和R 4代表烷基，芳基，烷氧基羰基或氰基，及其制备方法，其包括使5-烷氧基-2（3H） - 恶唑酮与α，β-不饱和酮 在溶剂中存在路易斯酸。

    Trifluoro-substituted benzoic acid, esters thereof, and process for producing the same
    23.
    发明授权
    Trifluoro-substituted benzoic acid, esters thereof, and process for producing the same 失效
    三氟取代的苯甲酸及其酯，及其制备方法

    公开(公告)号：US6160171A

    公开(公告)日：2000-12-12

    申请号：US242441

    申请日：1999-02-17

    申请人： Yasuhito Yamamoto ,  Yasuhiro Yoneda ,  Kikuo Ataka ,  Naoyuki Yokota

    发明人： Yasuhito Yamamoto ,  Yasuhiro Yoneda ,  Kikuo Ataka ,  Naoyuki Yokota

    IPC分类号： C07C63/70 ,  C07C69/76 ,  C07C51/363

    CPC分类号： C07C69/76 ,  C07C63/70

    摘要： The present invention is to provide a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzoic acid, 2,3,4-trifluoro-5-trifluoromethylbenzoic acid, esters thereof, which are useful as a starting material for synthesizing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzoic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.

    摘要翻译： PCT No.PCT / JP97 / 02856 Sec。 371日期1999年2月17日 102（e）1999年2月17日PCT PCT 1997年8月19日PCT公布。 出版物WO98 / 07682 日期：1998年2月26日本发明提供三氟取代的苯甲酸，其酯，特别是2,3,4-三氟-5-碘苯甲酸，2,3,4-三氟-5-三氟甲基苯甲酸，酯 可用作合成可用作药物的喹诺酮羧酸化合物的起始原料，抗菌剂或抗病毒剂，以及制备这些化合物和2,4,5-三氟-3-碘代苯甲酸的方法， 2,4,5-三氟-3-三氟甲基苯甲酸及其酯。

    Process of separation and purification of a propargyl alcohols
    24.
    发明授权
    Process of separation and purification of a propargyl alcohols 失效
    炔丙醇的分离和纯化方法

    公开(公告)号：US5043495A

    公开(公告)日：1991-08-27

    申请号：US475892

    申请日：1990-01-30

    申请人： Fumio Toda ,  Koichi Tanaka ,  Kikuo Ataka

    发明人： Fumio Toda ,  Koichi Tanaka ,  Kikuo Ataka

    IPC分类号： C07C29/88 ,  C07B57/00 ,  C07C27/00 ,  C07C29/76 ,  C07C33/30 ,  C07C33/48 ,  C07C67/00 ,  C07D295/02 ,  C07D295/03 ,  C07D487/04

    CPC分类号： C07D295/03 ,  C07C29/76 ,  C07C33/48 ,  C07D487/04 ,  C07B2200/07

    摘要： A process of separation and purification of a propargyl alcohol which comprises treating a propargyl alcohol represented by Formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2 represents a substituent which is different from each other, and is selected from the group consisting of a C.sub.1 -C.sub.8 alkyl group, a phenyl group; a halophenyl group, a phenyl group having at least one methyl substituent, an aralkyl group and a cycloalkyl group,which is chemically or optically impure,with a tertiary diamine represented by Formula (II): ##STR2## wherein each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be the same or different and represents an aralkyl group or an alkyl group having 1 to 6 carbon atoms; and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be bonded to each other,to form a crystalline complex compound of the propargyl alcohol represented by Formula (I) and the tertiary diamine represented by Formula (II), separating and purifying the resulting compound, and treating the resultant compound with an acid to isolate the propargyl alcohol represented by Formula (I).

    Process for preparing p-bromophenoxyacetaldehyde dialkylacetal compounds
    26.
    发明授权
    Process for preparing p-bromophenoxyacetaldehyde dialkylacetal compounds 失效
    制备对溴苯氧乙醛二烷基缩醛化合物的方法

    公开(公告)号：US4982008A

    公开(公告)日：1991-01-01

    申请号：US397995

    申请日：1989-08-23

    申请人： Kikuo Ataka ,  Masahiko Kohno

    发明人： Kikuo Ataka ,  Masahiko Kohno

    IPC分类号： C07C41/48 ,  C07C43/315 ,  C07C67/00

    CPC分类号： C07C41/48

    摘要： There is disclosed a process for preparing a p-bromophenoxyacetaldehyde dialkylacetal derivative represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent a hydrogen atom or a lower alkyl group and R.sup.3 represents an alkyl group having 1 to 6 carbon atoms,which comprises reacting a bromine to a phenoxyacetaldehyde dialkylacetal represented by the formula: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meanings as defined above,and then the reaction mixture is treated with an alkali metal hydroxide or alcoholate dissolved in an alcohol represented by the formula:R.sup.3 OHwherein R.sup.3 has the same meaning as defined above.